Colorectal cancer, diabetes and survival: Epidemiological insights

Zanders, M.M.J.; Vissers, Pauline A. J.; Haak, Harm R.; Poll‐Franse, Lonneke V. van de

doi:10.1016/j.diabet.2013.12.007

Cited by 29 publications

(31 citation statements)

References 73 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Recent meta-analysis or systematic review papers revealed that uncontrolled diabetes, 14 obesity and underweight, 15 smoking, 16 western dietary pattern, 4 and physical inactivity 4 were correlated with poor overall survival. We found that underweight, smoking, and physically inactivity were all associated with all-cause mortality risk in line with the previous studies.…”

Section: Discussionmentioning

confidence: 99%

Characteristics and prognosis of Japanese colorectal cancer patients: The BioBank Japan Project

Tamakoshi

Nakamura

Ukawa

et al. 2017

Journal of Epidemiology

View full text Add to dashboard Cite

BackgroundColorectal cancer is the third most common cancer worldwide, and in Japan, it is estimated that about 10% of men and 8% of women will be diagnosed with colorectal cancer during their lifetime.MethodsWe focused on 5864 participants (3699 men and 2165 women) who had colorectal cancer and were registered with BioBank Japan (BBJ) between April 2003 and March 2008. Characteristics of colon and rectal cancer patients were calculated separately. Among the enrolled patients registered in BBJ within 90 days after diagnosis, we also calculated the 5-year cumulative and relative survival rates, and estimated the effect of lifestyle factors on all-cause mortality.ResultsOur participants included younger men than those in the Patient Survey and the Cancer Registry Japan. In more than 95% of cases the histological type was adenocarcinoma both in colon and rectal cancer. Rectal cancer patients tended to eat more meat and less green leafy vegetables compared with colon cancer patients. The 5-year cumulative survival rate was 73.0% (95% CI; 70.1%–75.7%) and the 5-year relative survival rate was 80.6% (77.4%–83.6%), respectively, for colon cancer. For rectal cancer, the rates were 73.3% (69.1%–77.0%) and 80.9% (76.3%–85.0%), in the same order. Lifestyle factors such as consuming less green leafy vegetables, being underweight, smoking, not consuming alcoholic beverages and being physically inactive were found to be related to poor survival.ConclusionsWe described lifestyle characteristics of colorectal cancer patients in BBJ and examined the impacts on subsequent all-cause mortality.

show abstract

Section: Discussionmentioning

confidence: 99%

Characteristics and prognosis of Japanese colorectal cancer patients: The BioBank Japan Project

Tamakoshi

Nakamura

Ukawa

et al. 2017

Journal of Epidemiology

View full text Add to dashboard Cite

show abstract

“…In general, patients with diabetes have a poorer survival and increased risk of developing colorectal cancer . The increased risk of colorectal cancer is probably due to hyperinsulinemia, hyperglycemia and chronic inflammation .…”

Section: Discussionmentioning

confidence: 99%

“…Diabetes mellitus and colorectal cancer share several risk factors including obesity and physical inactivity, and diabetes is proven to be an independent risk factor for developing colorectal cancer . Several studies have shown that patients with both colorectal cancer and diabetes have a lower survival compared to patients without diabetes, whereas other studies have reported no association . Metformin is the drug of choice for treatment of type 2 diabetes.…”

Section: Introductionmentioning

confidence: 99%

Association between metformin use after surgery for colorectal cancer and oncological outcomes: A nationwide register‐based study

Fransgaard

Thygesen

Gögenur³

2018

Intl Journal of Cancer

View full text Add to dashboard Cite

Colorectal cancer is one of the most common malignancies in the Western world, and even after surgical removal, there is a high recurrence rate. Metformin treatment has been associated with a reduced risk of developing cancer, but whether metformin influences the risk of recurrence is unknown. The aim of our study was to examine the association between treatment with metformin and recurrence-free, disease-free survival and all-cause mortality after surgery for colorectal cancer. The study was an observational register-based study and included 25,785 patients, of which 1,116 had medically treated diabetes and 966 started metformin treatment at some point postoperatively. Diabetes was not associated with neither disease-free (HR = 1.09, 95% CI 0.97-1.21, p = 0.15) nor recurrence-free survival (HR = 1.13, 95% CI 0.95-1.35, p = 0.17). The study found no difference in regards to disease-free or recurrence-free survival between the metformin treated group (HR = 1.06, 95% CI 0.87-1.15, p = 0.57, HR = 1.01, 95% CI 0.89-1.15, p = 0.85) and non-diabetic patients. Patients with diabetes had increased all-cause mortality (HR = 1.29, 95% CI 1.16-1.45, p < 0.0001). Metformin treatment did not affect all-cause mortality (HR = 1.07, 95% CI 0.94-1.22, p = 0.33) compared to non-diabetic patients. In conclusion, our study did not find an association between diabetes or metformin treatment and recurrence-free or disease-free survival after surgery for colorectal cancer. However, diagnosis of diabetes is associated with increased all-cause mortality.

show abstract

“…The incidence of diabetes mellitus has been increasing vastly in most countries, including Korea [8,9], and it undoubtedly represents one of the most challenging health issues of the 21st century [10]. Many studies have reported that diabetes mellitus is related with the increasing incidence of CRC [7,[11][12][13][14][15][16]. Recently, diabetes mellitus, as well as impaired fasting glucose (IFG) as a marker of pre-diabetes, has been spotlighted as a way to minimize the medical and socio-economic burden of diabetes mellitus, by permitting early detection and intervention.…”

Section: Introductionmentioning

confidence: 99%

Association between fasting serum glucose levels and incidence of colorectal cancer in Korean men: The Korean Cancer Prevention Study-II

Kim

Linton

2014

Metabolism

View full text Add to dashboard Cite

Colorectal cancer, diabetes and survival: Epidemiological insights

Cited by 29 publications

References 73 publications

Characteristics and prognosis of Japanese colorectal cancer patients: The BioBank Japan Project

Characteristics and prognosis of Japanese colorectal cancer patients: The BioBank Japan Project

Association between metformin use after surgery for colorectal cancer and oncological outcomes: A nationwide register‐based study

Association between fasting serum glucose levels and incidence of colorectal cancer in Korean men: The Korean Cancer Prevention Study-II

Contact Info

Product

Resources

About