Colorectal cancer-derived extracellular vesicles induce liver premetastatic immunosuppressive niche formation to promote tumor early liver metastasis

Yang, Xuyang; Zhang, Yaguang; Zhang, Yang; Li, Huifang; Li, Li; Wu, Yangping; Chen, Xiangzheng; Qiu, Lei; Han, Junhong; Wang, Ziqiang

doi:10.1038/s41392-023-01384-w

Cited by 11 publications

(8 citation statements)

References 5 publications

(6 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Correspondingly, we identified the role of TEVs in promoting metastasis in melanoma ( 52 ) and NB ( 15 ) models by inducing the formation of pre-metastatic niche at potential metastatic sites like lung and liver respectively. Several other studies have demonstrated the role of TEVs in inducing PMN via different mechanisms in multiple cancer models ( 53 – 56 ). Breast cancer cell-derived EVs induced PMN by suppressing the glucose uptake of the niche resident non-tumor cells, thereby increasing nutrient availability for incoming tumor cells and facilitating their growth in breast cancer model ( 54 ).…”

Section: Tumor Derived Evsmentioning

confidence: 97%

“…Breast cancer cell-derived EVs induced PMN by suppressing the glucose uptake of the niche resident non-tumor cells, thereby increasing nutrient availability for incoming tumor cells and facilitating their growth in breast cancer model ( 54 ). CRC-EVs were shown to affect the hepatic stellate cells, transforming them to CAFs, that induced the recruitment of myeloid derived suppressor cells to the livers, thereby inducing an immunosuppressive PMN ( 56 ). While PDAC-EVs were found to induce PMN in the liver by sequentially affecting the Kupffer cells, hepatic stellate cells, ultimately resulting in the recruitment of bone marrow derived macrophages and neutrophils ( 53 ).…”

Section: Tumor Derived Evsmentioning

confidence: 99%

See 1 more Smart Citation

Extracellular vesicles in neuroblastoma: role in progression, resistance to therapy and diagnostics

Dhamdhere,

Spiegelman

2024

Front. Immunol.

View full text Add to dashboard Cite

Neuroblastoma (NB) is the most common extracranial solid pediatric cancer, and is one of the leading causes of cancer-related deaths in children. Despite the current multi-modal treatment regimens, majority of patients with advanced-stage NBs develop therapeutic resistance and relapse, leading to poor disease outcomes. There is a large body of knowledge on pathophysiological role of small extracellular vesicles (EVs) in progression and metastasis of multiple cancer types, however, the importance of EVs in NB was until recently not well understood. Studies emerging in the last few years have demonstrated the involvement of EVs in various aspects of NB pathogenesis. In this review we summarize these recent findings and advances on the role EVs play in NB progression, such as tumor growth, metastasis and therapeutic resistance, that could be helpful for future investigations in NB EV research. We also discuss different strategies for therapeutic targeting of NB-EVs as well as utilization of NB-EVs as potential biomarkers.

show abstract

Section: Tumor Derived Evsmentioning

confidence: 97%

Section: Tumor Derived Evsmentioning

confidence: 99%

Extracellular vesicles in neuroblastoma: role in progression, resistance to therapy and diagnostics

Dhamdhere,

Spiegelman

2024

Front. Immunol.

View full text Add to dashboard Cite

show abstract

“…Interestingly, EVs harboring transforming growth factor-β (TGF-β1) provoke HSCs differentiation into CAFs by activating HSCs chemokines signaling. Moreover, myeloid-derived suppressor cells (MDSCs) are further recruited to abrogate NK cell cytotoxicity by repressing NKG2D expression [ 55 ].…”

Section: Role Of Sevs In Crc Progression and Metastasismentioning

confidence: 99%

The multifaceted role of extracellular vesicles (EVs) in colorectal cancer: metastasis, immune suppression, therapy resistance, and autophagy crosstalk

Rahmati,

Moeinafshar,

Rezaei

2024

J Transl Med

View full text Add to dashboard Cite

Extracellular vesicles (EVs) are lipid bilayer structures released by all cells and widely distributed in all biological fluids. EVs are implicated in diverse physiopathological processes by orchestrating cell–cell communication. Colorectal cancer (CRC) is one of the most common cancers worldwide, with metastasis being the leading cause of mortality in CRC patients. EVs contribute significantly to the advancement and spread of CRC by transferring their cargo, which includes lipids, proteins, RNAs, and DNAs, to neighboring or distant cells. Besides, they can serve as non-invasive diagnostic and prognostic biomarkers for early detection of CRC or be harnessed as effective carriers for delivering therapeutic agents. Autophagy is an essential cellular process that serves to remove damaged proteins and organelles by lysosomal degradation to maintain cellular homeostasis. Autophagy and EV release are coordinately activated in tumor cells and share common factors and regulatory mechanisms. Although the significance of autophagy and EVs in cancer is well established, the exact mechanism of their interplay in tumor development is obscure. This review focuses on examining the specific functions of EVs in various aspects of CRC, including progression, metastasis, immune regulation, and therapy resistance. Further, we overview emerging discoveries relevant to autophagy and EVs crosstalk in CRC.

show abstract

“…Additional mechanisms involve the formation of an immunosuppressive microenvironment. CRC-derived EVs carrying TGF-β1 induce the formation of immunosuppressive ecological sites in the liver prior to metastasis and promote tumor metastasis [ 227 ]. Furthermore, recent studies [ 228 ] have shown that hepatocyte-derived EVs in fatty liver enhance the progression of CRC liver metastases by promoting oncogenic Yes-associated protein signaling and an immunosuppressive microenvironment.…”

Section: Evs Determine the Direction Of Metastasis And Colonization O...mentioning

confidence: 99%

The role of extracellular vesicles in circulating tumor cell-mediated distant metastasis

Guo,

Huang,

et al. 2023

Mol Cancer

View full text Add to dashboard Cite

Current research has demonstrated that extracellular vesicles (EVs) and circulating tumor cells (CTCs) are very closely related in the process of distant tumor metastasis. Primary tumors are shed and released into the bloodstream to form CTCs that are referred to as seeds to colonize and grow in soil-like distant target organs, while EVs of tumor and nontumor origin act as fertilizers in the process of tumor metastasis. There is no previous text that provides a comprehensive review of the role of EVs on CTCs during tumor metastasis. In this paper, we reviewed the mechanisms of EVs on CTCs during tumor metastasis, including the ability of EVs to enhance the shedding of CTCs, protect CTCs in circulation and determine the direction of CTC metastasis, thus affecting the distant metastasis of tumors.

show abstract

Colorectal cancer-derived extracellular vesicles induce liver premetastatic immunosuppressive niche formation to promote tumor early liver metastasis

Cited by 11 publications

References 5 publications

Extracellular vesicles in neuroblastoma: role in progression, resistance to therapy and diagnostics

Extracellular vesicles in neuroblastoma: role in progression, resistance to therapy and diagnostics

The multifaceted role of extracellular vesicles (EVs) in colorectal cancer: metastasis, immune suppression, therapy resistance, and autophagy crosstalk

The role of extracellular vesicles in circulating tumor cell-mediated distant metastasis

Contact Info

Product

Resources

About