Colorectal cancer cell exosome and cytoplasmic membrane for homotypic delivery of therapeutic molecules

Jarak, Ivana; Isabel Santos, Ana; Helena Pinto, Ana; Domingues, Cátia; Silva, Inês; Melo, Raquel; Veiga, Francisco; Figueiras, Ana

doi:10.1016/j.ijpharm.2023.123456

Cited by 3 publications

(1 citation statement)

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“…An example of a promising therapeutic application of polymersomes was observed in colorectal cancer, one of the most fatal cancers worldwide [115]. 7-ethyl-10-hydroxy camptothecin (SN38), which is a more potent active metabolite of the well-known irinotecan (Topoisomerase-1 inhibitor), has compromised clinical application due to low solubility and poor stability, as it is converted into its inactive form under physiological pH.…”

Section: Chemotherapymentioning

confidence: 99%

Polymersomes as the Next Attractive Generation of Drug Delivery Systems: Definition, Synthesis and Applications

Fonseca,

Jarak,

Victor

et al. 2024

Materials

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Polymersomes are artificial nanoparticles formed by the self-assembly process of amphiphilic block copolymers composed of hydrophobic and hydrophilic blocks. They can encapsulate hydrophilic molecules in the aqueous core and hydrophobic molecules within the membrane. The composition of block copolymers can be tuned, enabling control of characteristics and properties of formed polymersomes and, thus, their application in areas such as drug delivery, diagnostics, or bioimaging. The preparation methods of polymersomes can also impact their characteristics and the preservation of the encapsulated drugs. Many methods have been described, including direct hydration, thin film hydration, electroporation, the pH-switch method, solvent shift method, single and double emulsion method, flash nanoprecipitation, and microfluidic synthesis. Considering polymersome structure and composition, there are several types of polymersomes including theranostic polymersomes, polymersomes decorated with targeting ligands for selective delivery, stimuli-responsive polymersomes, or porous polymersomes with multiple promising applications. Due to the shortcomings related to the stability, efficacy, and safety of some therapeutics in the human body, polymersomes as drug delivery systems have been good candidates to improve the quality of therapies against a wide range of diseases, including cancer. Chemotherapy and immunotherapy can be improved by using polymersomes to deliver the drugs, protecting and directing them to the exact site of action. Moreover, this approach is also promising for targeted delivery of biologics since they represent a class of drugs with poor stability and high susceptibility to in vivo clearance. However, the lack of a well-defined regulatory plan for polymersome formulations has hampered their follow-up to clinical trials and subsequent market entry.

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Section: Chemotherapymentioning

confidence: 99%