Colorectal Cancer and the Role of the Gut Microbiota—Do Medical Students Know More Than Other Young People?—Cross-Sectional Study

Helisz, Paulina; Dziubanek, Grzegorz; Krupa‐Kotara, Karolina; Gwioździk, Weronika; Grajek, Mateusz; Głogowska-Ligus, Joanna

doi:10.3390/nu14194185

Cited by 4 publications

(2 citation statements)

References 34 publications

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“…In addition alterations in the microbiota in the gut may also be responsible for the increased risk of IBS with oral ulcers (21). The human gut contains a diverse microbial ecosystem, collectively known as the gut microbiota (22), which plays an important role in digestion, metabolism and immune system regulation (23). Disturbances in this ecosystem can trigger various pathological processes, including in ammation and immune dysregulation.…”

Section: Discussionmentioning

confidence: 99%

Irritable Bowel Syndrome and the Risk of Mouth Ulcers: Insights from a Mendelian Randomization Study

AO,

LIU,

Ting

et al. 2024

Preprint

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Background Irritable bowel syndrome (IBS) is a common functional gastrointestinal disorder characterised by chronic abdominal pain and altered bowel habits. However, IBS is often associated with a variety of comorbidities, and the causal relationship between IBS and oral ulcers is currently unclear.Methods A Two-sample Mendelian randomization study was used to investigate the relationship between irritable bowel syndrome and oral ulcers, with Cochran's Q test testing for heterogeneity between instrumental variables (IV). Horizontal pleiotropy was tested by MR-Egger regression intercept analysis and MR-PRESSO analysis.Results MR analysis revealed a significant causal relationship between irritable bowel syndrome and increased risk of developing oral ulcers for IVW (OR = 1.023, 95% CI: 1.007–1.040; p = 0.003). Similar results were observed in the weighted median (OR = 1.022, 95% CI: 1.003–1.042; p = 0.018). Sensitivity analyses and Cochran's Q test did not reveal the presence of pleiotropy and heterogeneity.Conclusions The present study suggests that oral ulcers may be a complication of irritable bowel syndrome and the results have important clinical implications, however, the biological mechanisms of this association need to be further explored.

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Section: Discussionmentioning

confidence: 99%

Irritable Bowel Syndrome and the Risk of Mouth Ulcers: Insights from a Mendelian Randomization Study

AO,

LIU,

Ting

et al. 2024

Preprint

View full text Add to dashboard Cite

show abstract

“…An important factor modulating the composition of the gut microbiota is a well-balanced diet based on whole-grain products and large amounts of vegetables and fruit, which are sources of dietary fiber. In contrast, the 'Western' dietary model, which includes a high intake of processed and high-fat products, positively correlates with the development of intestinal dysbiosis, which can cause gastrointestinal symptoms [18][19][20]. In addition, the presence of gastrointestinal dysbiosis influences the increased incidence of abnormal eating behaviors, which in most cases include irregular food intake as well as food avoidance.…”

Section: The Brain-gut Axis In the Context Of Gastrointestinal (Gi) T...mentioning

confidence: 99%

Psychobiotics as an Intervention in the Treatment of Irritable Bowel Syndrome: A Systematic Review

Gwioździk

Helisz

Grajek

et al. 2023

Applied Microbiology

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Today’s perceived excess of work versus rest and excessive stressful situations are one of the potential factors for an increasing number of gastrointestinal disorders. Although the prevalence of irritable bowel syndrome (IBS) varies widely, it is assumed that up to 15% of the general population may be affected. Symptoms resulting from IBS take the form of pain, including difficulties with bowel movements, bloating, and a feeling of overflowing in the intestines. These symptoms have a negative impact on patients’ quality of life, so any possible intervention supported by Evidence-Based Medicine should effectively contribute to their improvement. In the following review, the authors compile the current knowledge based on the findings of researchers from around the world. The topic of probiotic therapy is increasingly discussed in the field of lower gastrointestinal disorders, and thus the authors discover links between probiotic strains and the improvement of health quality in patients with IBS, taking into consideration the ways it affects patients’ mental health. As a result, a systematic review was prepared based on 60 items of recent literature, of which more than 80% were published in the last 5 years.

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Unraveling the Complex Interconnection between Specific Inflammatory Signaling Pathways and Mechanisms Involved in HIV-Associated Colorectal Oncogenesis

Damane

Mulaudzi

Kader

et al. 2023

Cancers

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The advancement of HIV treatment has led to increased life expectancy. However, people living with HIV (PLWH) are at a higher risk of developing colorectal cancers. Chronic inflammation has a key role in oncogenesis, affecting the initiation, promotion, transformation, and advancement of the disease. PLWH are prone to opportunistic infections that trigger inflammation. It has been documented that 15–20% of cancers are triggered by infections, and this percentage is expected to be increased in HIV co-infections. The incidence of parasitic infections such as helminths, with Ascariasis being the most common, is higher in HIV-infected individuals. Cancer cells and opportunistic infections drive a cascade of inflammatory responses which assist in evading immune surveillance, making them survive longer in the affected individuals. Their survival leads to a chronic inflammatory state which further increases the probability of oncogenesis. This review discusses the key inflammatory signaling pathways involved in disease pathogenesis in HIV-positive patients with colorectal cancers. The possibility of the involvement of co-infections in the advancement of the disease, along with highlights on signaling mechanisms that can potentially be utilized as therapeutic strategies to prevent oncogenesis or halt cancer progression, are addressed.

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Colorectal Cancer and the Role of the Gut Microbiota—Do Medical Students Know More Than Other Young People?—Cross-Sectional Study

Cited by 4 publications

References 34 publications

Irritable Bowel Syndrome and the Risk of Mouth Ulcers: Insights from a Mendelian Randomization Study

Irritable Bowel Syndrome and the Risk of Mouth Ulcers: Insights from a Mendelian Randomization Study

Psychobiotics as an Intervention in the Treatment of Irritable Bowel Syndrome: A Systematic Review

Unraveling the Complex Interconnection between Specific Inflammatory Signaling Pathways and Mechanisms Involved in HIV-Associated Colorectal Oncogenesis

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