Colorectal cancer and adenomas are rare in individuals of Turkish descent living in the Zaanstreek region in the Netherlands

Loffeld, S. M. L. A.; Loffeld, R. J. L. F.

doi:10.1007/s00432-010-0799-6

Cited by 2 publications

(2 citation statements)

References 19 publications

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“…In an earlier study done in the Zaanstreek region it was already shown that colorectal cancer is rarely diagnosed in patients of Turkish descent. The present study confirms these earlier findings (7).…”

Section: Discussionsupporting

confidence: 94%

Yield of endoscopy of the lower digestive tract in relation to ethnic descent

Loffeld¹,

Liberov²,

Dekkers³

2019

J. Gastrointest. Oncol

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Background: Not much is known of the yield of endoscopy in relation to ethnic descent. The aim is to study endoscopy of the lower digestive tract in relation to the ethnicity. Methods: A prospectively collected dataset was used. Presence four endoscopic findings (diverticuli, polyps, colorectal cancer, and signs of inflammation) was studied. The patients were divided in four groups. Group 1 patients of Western descent, group 2 patients of Turkish descent, group 3 patients originating from Morocco, Northern Africa and the Middle East, and, group 4 patients of Asian descent. Results: In group 1, 35,340 procedures were done in 24,223 patients, in group 2 this was 1,776 in 1,338 patients respectively. In groups 3 and 4 this was 465 in 371 patients, and 416 in 305 patients. There was no difference in gender between the four groups, the number of women undergoing endoscopy was higher in all groups. Overall abnormalities in colon and rectum were significantly more often seen in group 1.Colorectal cancer was significantly less often diagnosed in patients of groups 3 and 4. Polyp(s) were significantly less often seen in patients of groups 2 and 3. While diverticulosis of the colon was significantly more often diagnosed in patients of group 1. Signs of inflammation in colon and/or rectum were significantly more often seen in patients of groups 2, 3, and 4. Conclusions: There are clear differences in presence of colorectal abnormalities in patients from different ethnic descent. The implication of this finding in daily practice is not obvious.

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Section: Discussionsupporting

confidence: 94%

Yield of endoscopy of the lower digestive tract in relation to ethnic descent

Loffeld¹,

Liberov²,

Dekkers³

2019

J. Gastrointest. Oncol

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“…9,10 Adenomas are the main precursor lesions to most sporadic colorectal cancers and develop through the complex interactions of environmental and genetic risk factors. 11 Although recent reports have suggested that the risk of colorectal adenoma may be influenced by racial differences 12,13 in admixed populations, these findings are based on reported ethnicity rather than measured genetic ancestry. Self-reported measures of ethnicity in admixed populations are notoriously inaccurate regarding the individual ancestry.…”

Section: Introductionmentioning

confidence: 99%

Genetic ancestry is associated with colorectal adenomas and adenocarcinomas in Latino populations

et al. 2014

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Colorectal cancer rates in Latin American countries are less than half of those observed in the United States. Latin Americans are the resultant of generations of an admixture of Native American, European, and African individuals. The potential role of genetic admixture in colorectal carcinogenesis has not been examined. We evaluate the association of genetic ancestry with colorectal neoplasms in 190 adenocarcinomas, 113 sporadic adenomas and 243 age-and sex-matched controls enrolled in a multicentric case-control study in Colombia. Individual ancestral genetic fractions were estimated using the STRUCTURE software, based on allele frequencies and assuming three distinct population origins. We used the Illumina Cancer Panel to genotype 1,421 sparse single-nucleotide polymorphisms (SNPs), and Northern and Western European ancestry, LWJ and Han Chinese in Beijing, China populations from the HapMap project as references. A total of 678 autosomal SNPs overlapped with the HapMap data set SNPs and were used for ancestry estimations. African mean ancestry fraction was higher in adenomas (0.13, 95% confidence interval (95% CI) ¼ 0.11-0.15) and cancer cases (0.14, 95% CI ¼ 0.12-0.16) compared with controls (0.11, 95% CI ¼ 0.10-0.12). Conditional logistic regression analysis, controlling for known risk factors, showed a positive association of African ancestry per 10% increase with both colorectal adenoma (odds ratio (OR) ¼ 1.12, 95% CI ¼ 0.97-1.30) and adenocarcinoma (OR ¼ 1.19, 95% CI ¼ 1.05-1.35). In conclusion, increased African ancestry (or variants linked to it) contributes to the increased susceptibility of colorectal cancer in admixed Latin American population.

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Colorectal cancer and adenomas are rare in individuals of Turkish descent living in the Zaanstreek region in the Netherlands

Cited by 2 publications

References 19 publications

Yield of endoscopy of the lower digestive tract in relation to ethnic descent

Yield of endoscopy of the lower digestive tract in relation to ethnic descent

Genetic ancestry is associated with colorectal adenomas and adenocarcinomas in Latino populations

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