2020
DOI: 10.1111/his.14278
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Colorectal adenocarcinomas diagnosed following a negative faecal immunochemical test show high‐risk pathological features in a colon screening programme

Abstract: Aims The faecal immunochemical test (FIT) is used every 2 years to screen average‐risk British Columbians aged 50–74 years, with follow‐up colonoscopy for positive results. Non‐screen‐detected colorectal adenocarcinomas are defined as those detected within 25 months following a negative FIT. We aimed to more clearly characterise these malignancies. Methods and results A medical chart and focused pathology review of colorectal malignancies from 926 individuals who completed FIT in the British Columbia Colon Scr… Show more

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Cited by 4 publications
(9 citation statements)
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“…The FIT-IC proportion in Flanders during 2013–2018 was 13%, which lies within the range of FIT-IC proportion of 7–23% in other screening programmes using a FIT cut-off between 10 and 20 µg Hb/g [ 8 12 ]. Our study also supports previous findings that ICs after a negative faecal occult blood test are more common in women, [ 9 , 13 , 16 – 19 ] older people [ 16 , 20 , 36 ], in the right side of the colon [ 8 , 9 , 11 , 16 – 19 , 22 ] or in the rectum [ 10 , 17 , 37 ], at a more advanced stage [ 8 14 , 16 , 22 , 31 , 37 ] and with a higher grade [ 14 , 31 ], compared to screen-detected CRCs. Prior literature has proposed several explanations for these associations but definitive conclusions have not been reached.…”
Section: Discussionsupporting
confidence: 92%
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“…The FIT-IC proportion in Flanders during 2013–2018 was 13%, which lies within the range of FIT-IC proportion of 7–23% in other screening programmes using a FIT cut-off between 10 and 20 µg Hb/g [ 8 12 ]. Our study also supports previous findings that ICs after a negative faecal occult blood test are more common in women, [ 9 , 13 , 16 – 19 ] older people [ 16 , 20 , 36 ], in the right side of the colon [ 8 , 9 , 11 , 16 – 19 , 22 ] or in the rectum [ 10 , 17 , 37 ], at a more advanced stage [ 8 14 , 16 , 22 , 31 , 37 ] and with a higher grade [ 14 , 31 ], compared to screen-detected CRCs. Prior literature has proposed several explanations for these associations but definitive conclusions have not been reached.…”
Section: Discussionsupporting
confidence: 92%
“…Compared to screen-detected CRCs, FIT-ICs exhibited a higher grade and aggressive histotype (signet ring cell and mucinous carcinomas) [ 14 ]. However, it is still unclear to what degree FIT-ICs are due to FIT false-negative tests or a faster growth pathway of high-grade and aggressive histotype tumours.…”
Section: Discussionmentioning
confidence: 99%
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