Colorectal adenocarcinoma: risks, prevention and diagnosis

Thrumurthy, Sri G.; Thrumurthy, Sasha S D; Gilbert, Catherine E; Ross, Paul; Haji, Amyn

doi:10.1136/bmj.i3590

Cited by 53 publications

(52 citation statements)

References 55 publications

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“…There are survival advantages associated with further surgery in patients with locally recurrent rectal cancer, limited liver and lung metastases, as well as small volume peritoneal disease. Refer these patients to centres with expertise in managing advanced and recurrent colorectal cancer 3. A wide range of increasingly effective oncological interventions is available through specialist centres (which is beyond the scope of this article).…”

Section: How Is Metastatic and Recurrent Disease Managed?mentioning

confidence: 99%

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Management of colorectal cancer

Brown

Solomon

Mahon

et al. 2019

BMJ

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Section: How Is Metastatic and Recurrent Disease Managed?mentioning

confidence: 99%

“…The presentation and diagnosis of colorectal cancers have been covered recently in another article in The BMJ 3…”

mentioning

confidence: 99%

Management of colorectal cancer

Brown

Solomon

Mahon

et al. 2019

BMJ

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“…Several studies demonstrated that physical activity is associated with a 10-70% reduced risk of colorectal cancer [16,62,71,72,[87][88][89][90][91][92]. It seems that different physical activities exert different effects on colorectal cancer risk [61].…”

Section: Colorectal Cancermentioning

confidence: 99%

Physical Activity and Gastrointestinal Cancer Risk: A Review

Tajabadi

Akbari

Hafez

2019

Acta Medica Bulgarica

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Introduction: Western lifestyle characterized by increased consumption of red meat, fat, processed food, smoking, alcohol drinking, lower consumption of vegetables and physical inactivity has been associated with a higher gastrointestinal cancer risk. Digestive system cancers are diagnosed at late stages when they show poor response to treatment and are associated with a high mortality rate. Colorectal, gastric, esophageal and pancreatic cancers are among the most common cancers worldwide. Studies show that more than 50% of gastrointestinal cancers develop as a result of inappropriate lifestyle. An inverse association between physical activity and many chronic diseases has been proved so far. However, the association between physical activity and some gastrointestinal cancers is still controversial. This study was aimed to determine the association between physical activity and gastrointestinal cancers risk. Methods: We conducted a comprehensive search of English and Persian databases from February 2007 till December 2017, for studies investigating the association of physical activity and risk of gastrointestinal cancers. Finally, after reading full text of articles, 123 studies were included. Results: Physical activity can be helpful in reducing the risk of gastrointestinal cancer, especially colon and pancreatic cancers. The risk reduction is not similar for different types of gastrointestinal cancers and also among males and females. Conclusion: Different types of physical activity are associated with a lower risk of gastrointestinal cancer. However, it is unknown which type and intensity of physical activity are associated with a protective effect against gastro-intestinal cancer.

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“…Colorectal adenocarcinoma (CRA) is the main form of colorectal cancer (CRC), accounting for more than 95% of CRCs, and has high morbidity and mortality. 1 Due to its high heterogeneity, traditional predictors such as age and TNM stage are not su cient to accurately predict the survival risk of CRA patients. Exploring novel biomarkers is necessary to provide effective and personalized predictive tools.…”

Section: Introductionmentioning

confidence: 99%

A novel seven-microRNA signature predicts prognosis in colorectal adenocarcinoma

Jiang¹,

Xie²,

Jiang³

2020

Preprint

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Background Colorectal carcinoma, primarily colorectal adenocarcinoma (CRA), is one of the most common malignancies, ranking third, while contributing the second cause of cancer death in the world. MicroRNAs, a type of non-coding RNA, play an important role in regulating cancer-related cell biology. To simply and accurately predict survival risk for CRA patients, we identified a novel seven-miRNA signature. The microRNA (miRNA) expression profiles along with clinical data of 512 CRA patients were downloaded from The Cancer Genome Atlas (TCGA) database, and 415 patients with complete clinical information were further divided into training set and test set randomly. To construct the prognostic signature in the training set, a series of Cox regression analyses were performed, including univariate regression, least absolute shrinkage and selectionator operator (LASSO) - Cox regression, and multivariate regression. Results Seven predictive miRNAs (miR-153-2, miR-3199-2, miR-144, miR-887, miR-561, miR-3684, and miR-505) were ultimately screened. The ROC curves for 5-year survival in the training set, test set and entire set were 0.889, 0.742, and 0.816, respectively. Kaplan-Meier analysis results of the three sets all showed p <0.05. Further analyses demonstrated that the signature was an independent prognostic risk factor for CRA patients, and its predictive ability was superior to age and TNM stage. Functional enrichment analysis revealed that p53 and ErbB pathways were related to the prognostic regulation of miRNAs in the signature in CRA patients.Conclusion Our study demonstrated the potential of this novel seven-miRNA signature to independently predict overall survival in patients with CRA. Functional enrichment analysis further revealed the possible regulatory role of miRNAs in the signature in CRA-related cell biological processes and signaling pathways.

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Colorectal adenocarcinoma: risks, prevention and diagnosis

Cited by 53 publications

References 55 publications

Management of colorectal cancer

Management of colorectal cancer

Physical Activity and Gastrointestinal Cancer Risk: A Review

A novel seven-microRNA signature predicts prognosis in colorectal adenocarcinoma

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