Colorado Twin Registry

Rhea, Sally Ann; Gross, Andy A.; Haberstick, Brett C.; Corley, Robin P.

doi:10.1375/183242706779462895

Cited by 81 publications

(91 citation statements)

References 22 publications

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“…CD symptom severity was measured as the number of endorsed symptoms, with scores standardized by participants’ sex and age. Substance use and conduct disorder measures were normed with regard to age and sex on adolescents from several samples (Rhea et al, 2006; Stallings et al, 2003). …”

Section: Methodsmentioning

confidence: 99%

Modeling pubertal timing and tempo and examining links to behavior problems.

Beltz

Corley

Bricker

et al. 2014

Developmental Psychology

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Research on the role of puberty in adolescent psychological development requires attention to the meaning and measurement of pubertal development. Particular questions concern the utility of self report, the need for complex models to describe pubertal development, the psychological significance of pubertal timing versus tempo, and sex differences in the nature and psychological significance of pubertal development. We used longitudinal self-report data to model linear and logistic trajectories of pubertal development, and used timing and tempo estimates from these models, and from traditional approaches (age at menarche and time from onset of breast development to menarche), to predict psychological outcomes of internalizing and externalizing behavior problems, and early sexual activity. Participants (738 girls, 781 boys) reported annually from ages 9 through 15 on their pubertal development, and they and their parents reported on their behavior in mid-to-late adolescence and early adulthood. Self reports of pubertal development provided meaningful data for both boys and girls, producing good trajectories, and estimates of individuals’ pubertal timing and tempo. A logistic model best fit the group data. Pubertal timing was estimated to be earlier in the logistic compared to linear model, but linear, logistic, and traditional estimates of pubertal timing correlated highly with each other and similarly with psychological outcomes. Pubertal tempo was not consistently estimated, and associations of tempo with timing and with behavior were model dependent. Advances in modeling facilitate the study of some questions about pubertal development, but assumptions of the models affect their utility in psychological studies.

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Section: Methodsmentioning

confidence: 99%

Modeling pubertal timing and tempo and examining links to behavior problems.

Beltz

Corley

Bricker

et al. 2014

Developmental Psychology

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“…GWAS participants were drawn from several primary studies described elsewhere (Hartman et al 2008, Petrill et al 2003, Rhea et al 2006, Stallings et al 2005). The current sample of 1,901 unrelated adolescents was over-selected for adolescent BD, with half of the participants ascertained specifically from high-risk populations (i.e.…”

Section: Methodsmentioning

confidence: 99%

Genome-Wide Association Study of Behavioral Disinhibition in a Selected Adolescent Sample

et al. 2015

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Behavioral disinhibition (BD) is a quantitative measure designed to capture the heritable variation encompassing risky and impulsive behaviors. As a result, BD represents an ideal target for discovering genetic loci that predispose individuals to a wide range of antisocial behaviors and substance misuse that together represent a large cost to society as a whole. Published genome-wide association studies (GWAS) have examined specific phenotypes that fall under the umbrella of BD (e.g. alcohol dependence, conduct disorder); however no GWAS has specifically examined the overall BD construct. We conducted a GWAS of BD using a sample of 1,901 adolescents over-selected for characteristics that define high BD, such as substance and antisocial behavior problems, finding no individual locus that surpassed genome-wide significance. Although no single SNP was significantly associated with BD, restricted maximum likelihood analysis estimated that 49.3% of the variance in BD within the Caucasian sub-sample was accounted for by the genotyped SNPs (p=0.06). Gene-based tests identified seven genes associated with BD (p≤2.0×10−6). Although the current study was unable to identify specific SNPs or pathways with replicable effects on BD, the substantial sample variance that could be explained by all genotyped SNPs suggests that larger studies could successfully identify common variants associated with BD.

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“…Twins are relatively common, in some countries accounting for as much as 2-4% of the population, and the existence of national registries in many countries (Busjahn & Hur, 2006;Kaprio, 2006;Lichtenstein et al, 2006;Skytthe et al, 2006) and some U.S. states Rhea, Gross, Haberstick, & Corley, 2006) has made it relatively easy to undertake large-scale studies of twins. Although more recent twin registries are being established in many Asian countries as well (Ando et al, 2006;He, Ge, Zheng, Huang, & Zeng, 2006;Hur, Shin, Jeong, & Han, 2006;Li et al, 2006;Pang et al, 2006).…”

Section: Nih-pa Author Manuscriptmentioning

confidence: 99%

The End of Behavioral Genetics?

McGue

2010

Behav Genet

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Although genetic models were in the ascendance within psychology during the early 20 th century, the association of early behavioral genetic research with the eugenics movement served to discredit the field in the eyes of many. Twin and adoption studies throughout the latter half of the 20 th century helped to reestablish the importance of behavioral genetic models and set the stage for the current focus of the field on developing and testing models of gene-environment interplay. Research findings on developmental behavioral genetic research, gene-environment interaction, and the use of behavioral genetic models to test causal hypotheses are used to highlight the contributions of contemporary behavioral genetic research to psychological research. It is argued that future efforts to investigate models of gene-environment interplay will depend heavily of the field's ability to identify the specific genetic variants that contribute to individual differences in behavior. The anticipated yield from genome-wide association studies gives much reason to be optimistic about the future vitality of behavior genetics.The end of behavioral genetics? Recently the developmental psychologist, Richard Lerner, published a commentary entitled, "Another nine-inch nail for behavioral geneticists!" (Lerner, 2006). Lerner began his commentary with the lament, "Why do we have to keep reinterring behavior genetics" (p. 337), but concluded confident in the belief that a critical analysis of IQ adoption studies (Richardson & Norgate, 2006) had finally help put the field irretrievably where he felt it belonged, presumably six feet under. Singing the death knell of behavior genetics has been a popular pastime for critics of the field over the past 100 years, but critiques like that by Richardson and Norgate (2006) have done little to dampen interest in behavioral genetics. It is not that behavioral genetics is above criticism; quite the contrary there is much to criticize about the field. Rather, the reason Lerner and his fellow critics are engaged in the Sisyphean task of "reinterring" behavioral genetics is that they have failed to recognize the enormous impact the field has had on the way psychologists think about individual differences in behavior; they have failed to understand the essential nature of the behavioral genetic research paradigm.The purpose of this special issue of Acta Psychologica Sinica is, of course, to recognize the vitality of contemporary behavioral genetic research, not to mourn its demise. Nonetheless, even as we highlight research progress in the field, it can be helpful to consider how others have reacted to behavioral genetic findings, even the field's most enthusiastic critics. Behavioral genetics has often been caught up in controversy, sometimes unfairly, and an assessment of its current impact on psychology can benefit from both a discussion of the field's historical roots, with which I will begin, and speculation over its possible future, where I will end. NIH Public Access Author ManuscriptXin Li...

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Colorado Twin Registry

Cited by 81 publications

References 22 publications

Modeling pubertal timing and tempo and examining links to behavior problems.

Modeling pubertal timing and tempo and examining links to behavior problems.

Genome-Wide Association Study of Behavioral Disinhibition in a Selected Adolescent Sample

The End of Behavioral Genetics?

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