Color or money?: The impact of socioeconomic status and race/ethnicity on breast cancer mortality

Nnorom, Siobhan O; Akinyemi, Oluwasegun; Tran, Joseph; Baig, Hana; Cornwell, Edward E.; Wilson, Lori

doi:10.1016/j.amjsurg.2022.07.013

Cited by 4 publications

(4 citation statements)

References 18 publications

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“…Racial factors linked or not to socio-economic circumstances play a role in breast cancer outcome. Five-year survival was worse for Black compared to White women in each socioeconomic quartile with 5-year survival hazard ratios of 1.33, 1.23, and 1.20 ( p < 0.01) in the lowest, second, and third quartile, respectively [ 20 ]. The Eurocare 4 database reports striking differences in 5-year breast cancer survival between the Modena (86.9%) and Salerno (71.9) regions in Italy, for unknown reasons [ 21 ].…”

Section: Socioeconomicsmentioning

confidence: 99%

Breast Cancer: Impact of New Treatments?

Storme

2023

Cancers

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Background: Breast cancer treatment has seen tremendous progress since the early 1980s, with the first findings of new chemotherapy and hormone therapies. Screening started in the same period. Methods: A review of population data (SEER and the literature) shows an increase in recurrence-free survival until 2000 and it stagnates afterwards. Results: Over the period 1980-2000, the 15% survival gain was presented by pharma as a contribution of new molecules. The contribution of screening during that same period was not implemented by them, although screening has been accepted as a routine procedure in the States since the 1980s and everywhere else since 2000. Conclusions: Interpretation of breast cancer outcome has largely focused on drugs, whereas other factors, such as screening, prevention, biologics, and genetics, were largely neglected. More attention should now be paid to examining the strategy based on realistic global data.

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Section: Socioeconomicsmentioning

confidence: 99%

Breast Cancer: Impact of New Treatments?

Storme

2023

Cancers

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“…In contrast, the biology of the disease and the risk factors have been extensively explored. Still, gaps remain in understanding the socio-economic ( 4 , 5 ) and ethnic ( 6 , 7 ) disparities associated with breast cancer survival.…”

Section: Introductionmentioning

confidence: 99%

Breast cancer insights from Northern Israel: a comprehensive analysis of survival rates among Jewish and Arab women

Badran,

Campisi-Pinto,

Amna

et al. 2024

Front. Oncol.

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This study investigates breast cancer survival rates between 2000 and 2022 in northern Israel, focusing on ethnicity, socioeconomic status, age at diagnosis, and the Charlson Comorbidity Index. Analyzing data from Clalit Health Services, we studied 8,431 breast cancer patients (6,395 Jewish, 2,036 Arab). We compared five- and ten-year survival rates across different demographics. Ethnicity showed a minor impact on survival (OR 1.12, 95% CI: 0.93 - 1.35). Socioeconomic status had a significant effect, with a higher level of improving survival (OR 2.50, 95% CI: 2.04 – 3.08). Age was crucial; women 18-39 had better survival than 60-100, but no significant difference was found between the 18-39 and 40-59 age groups [OR (CI 0.90 – 1.53, p = 0.231)]. For the Charlson Comorbidity Index, women with scores of 3-10 showed lower survival compared to scores of 0 and 1-2. There was a notable improvement in five-year survival rates among patients aged 18-59 diagnosed from 2009-2018 (90.7%) compared to 2000-2008 (86.9%) (p = 0.0046), but not in patients aged 60-100. The study highlights that socioeconomic status, age, and comorbidity scores are significant in determining survival rates for breast cancer. The improvement in survival rates for younger patients diagnosed more recently reflects advancements in treatment and care. This research provides valuable insights into the factors affecting breast cancer survival rates, underscoring the role of socioeconomic status, age, and comorbidities while also highlighting the progress in breast cancer treatment over recent years.

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“…For several decades, non-Hispanic Black women have had substantially higher breast cancer (BC) mortality rates than non-Hispanic White women . Recent data from the Surveillance, Epidemiology, and End Results program show that between 2015 and 2019, Black women had 41% higher BC mortality compared with White women despite a 4% lower incidence of BC .…”

Section: Introductionmentioning

confidence: 99%

“…For several decades, non-Hispanic Black women have had substantially higher breast cancer (BC) mortality rates than non-Hispanic White women. 1 , 2 , 3 , 4 , 5 , 6 , 7 Recent data from the Surveillance, Epidemiology, and End Results program show that between 2015 and 2019, Black women had 41% higher BC mortality compared with White women despite a 4% lower incidence of BC. 8 The emergence and subsequent widening of this disparity over the past 40 years suggests that potentially modifiable and time-varying factors contribute.…”

Section: Introductionmentioning

confidence: 99%

Age, Body Mass Index, Tumor Subtype, and Racial and Ethnic Disparities in Breast Cancer Survival

Lipsyc-Sharf,

Ballman,

Campbell

et al. 2023

JAMA Netw Open

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ImportanceBlack women in the United States have higher breast cancer (BC) mortality rates than White women. The combined role of multiple factors, including body mass index (BMI), age, and tumor subtype, remains unclear.ObjectiveTo assess the association of race and ethnicity with survival among clinical trial participants with early-stage BC (eBC) according to tumor subtype, age, and BMI.Design, Setting, and ParticipantsThis cohort study analyzed survival data, as of November 12, 2021, from participants enrolled between 1997 and 2010 in 4 randomized adjuvant chemotherapy trials: Cancer and Leukemia Group B (CALGB) 9741, 49907, and 40101 as well as North Central Cancer Treatment Group (NCCTG) N9831, legacy groups of the Alliance of Clinical Trials in Oncology. Median follow-up was 9.8 years.ExposuresNon-Hispanic Black and Hispanic participants were compared with non-Hispanic White participants within subgroups of subtype (hormone receptor positive [HR+]/ERBB2 [formerly HER2] negative [ERBB2−], ERBB2+, and HR−/ERBB2−), age (&lt;50, 50 to &lt;65, and ≥65 years), and BMI (&lt;18.5, 18.5 to &lt;25.0, 25.0 to &lt;30.0, and ≥30.0).Main Outcomes and MeasuresRecurrence-free survival (RFS) and overall survival (OS).ResultsOf 9479 participants, 436 (4.4%) were Hispanic, 871 (8.8%) non-Hispanic Black, and 7889 (79.5%) non-Hispanic White. The median (range) age was 52 (19.0-89.7) years. Among participants with HR+/ERBB2− tumors, non-Hispanic Black individuals had worse RFS (hazard ratio [HR], 1.49; 95% CI, 1.04-2.12; 5-year RFS, 88.5% vs 93.2%) than non-Hispanic White individuals, although the global test for association of race and ethnicity with RFS was not significant within any tumor subtype. There were no OS differences by race and ethnicity in any subtype. Race and ethnicity were associated with OS in young participants (age &lt;50 years; global P = .008); young non-Hispanic Black participants (HR, 1.34; 95% CI, 1.04-1.71; 5-year OS, 86.6% vs 92.0%) and Hispanic participants (HR, 1.62; 95% CI, 1.16-2.29; 5-year OS, 86.2% vs 92.0%) had worse OS than young non-Hispanic White participants. Race and ethnicity were associated with RFS in participants with BMIs of 25 to less than 30, with non-Hispanic Black participants having worse RFS (HR, 1.81; 95% CI, 1.23-2.68; 5-year RFS, 83.2% vs 87.3%) than non-Hispanic White participants.Conclusions and RelevanceIn this cohort study, racial and ethnic survival disparities were identified in patients with eBC receiving standardized initial care, and potentially at-risk subgroups, for whom focused interventions may improve outcomes, were found.

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Color or money?: The impact of socioeconomic status and race/ethnicity on breast cancer mortality

Cited by 4 publications

References 18 publications

Breast Cancer: Impact of New Treatments?

Breast Cancer: Impact of New Treatments?

Breast cancer insights from Northern Israel: a comprehensive analysis of survival rates among Jewish and Arab women

Age, Body Mass Index, Tumor Subtype, and Racial and Ethnic Disparities in Breast Cancer Survival

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