Color opponency in horizontal cells of the vertebrate retina

Twig, Gilad; Levy, Hanna; Perlman, Ido

doi:10.1016/s1350-9462(02)00045-9

Cited by 47 publications

(34 citation statements)

References 201 publications

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“…In particular cases where a dominant or nondominant cone is found to provide a depolarizing influence, its hyperpolarizing V max was set to 0. types are dominated by red cone inputs (De Aguiar et al 2006;Djamgoz 1984;Djamgoz and Ruddock 1979;Djamgoz et al 1985;Ohtsuka and Kouyama 1986;Sakai et al 1997;Ventura et al 1999Yang et al 1983;Yazulla 1976). However, monophasic cells receiving dominant or nondominant inputs from more than one photoreceptor type, such as red and green (Dacey et al 1996(Dacey et al , 2000De Aguiar et al 2006;Downing and Djamgoz 1989;Hashimoto and Inokuchi 1981;Hashimoto et al 1988;Kamermans and Spekreijse 1995;Kamermans et al 1989b;Sakai et al 1997;Twig et al 2003;Yang et al 1983;Yazulla 1976), red and blue (Nelson 1985), green and blue (Djamgoz 1984;Djamgoz and Ruddock 1979;Djamgoz et al 1985;Yazulla 1976), or red, green, and blue (Asi and Perlman 1998;Dacey et al 1996;Twig et al 2003;Yazulla 1976) also exist.…”

Section: Non-uv Light Responsesmentioning

confidence: 99%

“…In goldfish, cone horizontal cells are classified as H1, H2, and H3 types, roughly in order of dendritic diameter. H1 cells are monophasic, H2 cells are biphasic, and H3 cells are triphasic (De Aguiar et al 2006;Downing and Djamgoz 1989;Stell et al 1975; for reviews, see Kamermans and Spekreijse 1995;Twig et al 2003). Selective cone contacts combine with feedback circuits between horizontal cells and cones (Kamermans et al 1991(Kamermans et al , 1989aStell and Lightfoot 1975) to comprise the underlying circuitry generating multiphasic horizontal cell responses to color.…”

Section: Introductionmentioning

confidence: 99%

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Spectral Responses in Zebrafish Horizontal Cells Include a Tetraphasic Response and a Novel UV-Dominated Triphasic Response

Connaughton

Nelson

2010

Journal of Neurophysiology

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Connaughton VP, Nelson R. Spectral responses in zebrafish horizontal cells include a tetraphasic response and a novel UV-dominated triphasic response. J Neurophysiol 104: 2407-2422, 2010. First published July 7, 2010 doi:10.1152/jn.00644.2009. Zebrafish are tetrachromats with red (R, 570 nm), green (G, 480 nm), blue (B, 415 nm), and UV (U, 362 nm) cones. Although neurons in other cyprinid retinas are rich in color processing neural circuitry, spectral responses of individual neurons in zebrafish retina, a genetic model for vertebrate color vision, are yet to be studied. Using dye-filled sharp microelectrodes, horizontal cell voltage responses to light stimuli of different wavelengths and irradiances were recorded in a superfused eyecup. Spectral properties were assessed both qualitatively and quantitatively. Six spectral classes of horizontal cell were distinguished. Two monophasic response types (L1 and L2) hyperpolarized at all wavelengths. L1 sensitivities peaked at 493 nm, near the G cone absorbance maximum. Modeled spectra suggest equally weighted inputs from both R and G cones and, in addition, a "hidden opponency" from blue cones. These were classified as RϪ/GϪ/(bϩ). L2 sensitivities were maximal at 563 nm near the R cone absorbance peak; modeled spectra were dominated by R cones, with lesser G cone contributions. B and UV cone signals were small or absent. These are RϪ/gϪ. Four chromatic (C-type) horizontal cells were either depolarized (ϩ) or hyperpolarized (Ϫ) depending on stimulus wavelength. These types are biphasic (Rϩ/GϪ/BϪ) with peak excitation at 467 nm, between G and B cone absorbance peaks, UV triphasic (rϪ/Gϩ/ UϪ) with peak excitation at 362 nm similar to UV cones, and blue triphasic (rϪ/Gϩ/BϪ/uϪ) and blue tetraphasic (rϪ/Gϩ/BϪ/uϩ), with peak excitation at 409 and 411 nm, respectively, similar to B cones. UV triphasic and blue tetraphasic horizontal cell spectral responses are unique and were not anticipated in previous models of distal color circuitry in cyprinids.

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Section: Non-uv Light Responsesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Spectral Responses in Zebrafish Horizontal Cells Include a Tetraphasic Response and a Novel UV-Dominated Triphasic Response

Connaughton

Nelson

2010

Journal of Neurophysiology

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“…Thus, when large spots or annuli are used to stimulate the retina with long-wavelength light, the photoresponses of medium and short-wavelength cones are expected to be of a more depolarizing pattern (Twig et al, 2003).…”

Section: Ganglion Cell Layer and Inner Nuclear Layermentioning

confidence: 99%

“…Since the receptive field size of C-type cells depends upon the wavelength and the intensity of the stimulating light, a complex relationship between amplitude and polarity of the photoresponse and the spatial and spectral properties of the light stimulus is expected (Twig et al, 2003).…”

Section: Ganglion Cell Layer and Inner Nuclear Layermentioning

confidence: 99%

c-Fos expression in the visual system of the tree shrew (Tupaia belangeri)

Poveda¹,

Kretz²

2009

Journal of Chemical Neuroanatomy

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“…Inhibitory feedback underlies the formation of center-surround antagonistic receptive fields, which support edge detection, create color opponency, and enhance contrast (Wu, 1992;Burkhardt, 1993;Twig et al, 2003). How this inhibition is generated is not yet understood.…”

Section: Introductionmentioning

confidence: 99%

Proton-Mediated Feedback Inhibition of Presynaptic Calcium Channels at the Cone Photoreceptor Synapse

Vessey

Stratis²,

Daniels³

et al. 2005

J. Neurosci.

115

136

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Generation of center-surround antagonistic receptive fields in the outer retina occurs via inhibitory feedback modulation of presynaptic voltage-gated calcium channels in cone photoreceptor synaptic terminals. Both conventional and unconventional neurotransmitters, as well as an ephaptic effect, have been proposed, but the intercellular messaging that mediates the inhibitory feedback signal from postsynaptic horizontal cells (HCs) to cones remains unknown. We examined the possibility that proton concentration in the synaptic cleft is regulated by HCs and that it carries the feedback signal to cones. In isolated, dark-adapted goldfish retina, we assessed feedback in the responses of HCs to light and found that strengthened pH buffering reduced both rollback and the depolarization to red light. In zebrafish retinal slices loaded with Fluo-4, depolarization with elevated K ϩ increased Ca signals in the synaptic terminals of cone photoreceptors. Kainic acid, which depolarizes HCs but has no direct effect on cones, depressed the K ϩ -induced Ca signal, whereas CNQX, which hyperpolarizes HCs, increased the Ca signals, suggesting that polarization of HCs alters inhibitory feedback to cones. We found that these feedback signals were blocked by elevated extracellular pH buffering, as well as amiloride and divalent cations. Voltage clamp of isolated HCs revealed an amiloride-sensitive conductance that could mediate modulation of cleft pH dependent on the membrane potential of these postsynaptic cells.

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Color opponency in horizontal cells of the vertebrate retina

Cited by 47 publications

References 201 publications

Spectral Responses in Zebrafish Horizontal Cells Include a Tetraphasic Response and a Novel UV-Dominated Triphasic Response

Spectral Responses in Zebrafish Horizontal Cells Include a Tetraphasic Response and a Novel UV-Dominated Triphasic Response

c-Fos expression in the visual system of the tree shrew (Tupaia belangeri)

Proton-Mediated Feedback Inhibition of Presynaptic Calcium Channels at the Cone Photoreceptor Synapse

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