2015
DOI: 10.1007/s00464-015-4615-x
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COLOR III: a multicentre randomised clinical trial comparing transanal TME versus laparoscopic TME for mid and low rectal cancer

Abstract: IntroductionTotal mesorectal excision (TME) is an essential component of surgical management of rectal cancer. Both open and laparoscopic TME have been proven to be oncologically safe. However, it remains a challenge to achieve complete TME with clear circumferential resections margin (CRM) with the conventional transabdominal approach, particularly in mid and low rectal tumours. Transanal TME (TaTME) was developed to improve oncological and functional outcomes of patients with mid and low rectal cancer.Method… Show more

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Cited by 317 publications
(223 citation statements)
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“…The first results demonstrate comparable short-term results for taTME and traditional laparoscopic TME. To improve promising results, the ongoing COLLOR III randomized trial compares taTME and laparoscopic TME for mid and low rectal carcinomas [21].…”
Section: Discussionmentioning
confidence: 99%
“…The first results demonstrate comparable short-term results for taTME and traditional laparoscopic TME. To improve promising results, the ongoing COLLOR III randomized trial compares taTME and laparoscopic TME for mid and low rectal carcinomas [21].…”
Section: Discussionmentioning
confidence: 99%
“…A combination of both taTME and RS will likely become a promising strategy in selected patients [59], while prospective randomized trials are needed to prove the advantages of this approach over conventional laTME [60].…”
Section: Resultsmentioning
confidence: 99%
“…Exclusion criteria are T1 tumors that can be treated by local excision, tumors with ingrowth in the internal sphincter or levator ani muscle, and all T4 tumors. All participating centers in the COLOR III trial will keep the coordinating center informed of all patients presenting with rectal cancer [17] . The ETAP-GRECCAR 11 randomized controlled trial is also comparing TaTME to laparoscopic TME.…”
Section: Clinical Trialsmentioning
confidence: 99%