Color Doppler ultrasonography diagnostic value in detection of malignant nodules in cysts with pathologically proven thyroid malignancy: a systematic review and meta-analysis

Darvish, Leili; Khezri, Mehrdad; Teshnizi, Saeed Hosseini; Roozbeh, Nasibeh; Dehkordi, Jalil Ghani; Amraee, Azadeh

doi:10.1007/s12094-019-02105-y

Cited by 6 publications

(8 citation statements)

References 50 publications

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“…Doppler indices like the resistive index (RI) and the peak systolic to the end diastolic velocity ratio (SDR) exhibited good diagnostic performance in discriminating between cold and hot nodules. 17 , 38…”

Section: Discussionmentioning

confidence: 99%

Duplex Hemodynamic Parameters of Both Superior and Inferior Thyroid Arteries in Evaluation of Thyroid Hyperfunction Disorders

Hussein¹,

Hamid²,

Samie³

et al. 2022

IJGM

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Background Thyrotoxicosis may be caused by Graves’ disease or destructive thyroiditis. Differentiation between causes of thyrotoxicosis is crucial as management will differ. 99m Technetium (Tc)-pertechnetate thyroid scintigraphy is currently the gold standard for this purpose, however, is expensive and uses ionizing radiation. Objective To evaluate the role of color flow Doppler Ultrasound (CDU) of the superior thyroid (STA) and inferior thyroid arteries (ITA) as an inexpensive, non-invasive tool that can aid in differentiating between Graves’ disease and thyroiditis and compare it with thyroid scintigraphy. Methods Sixty-nine patients with newly-diagnosed thyrotoxicosis and 30 controls were enrolled. Thyroid functions, thyroid scintigraphy, and CDU of STA and ITA with measurements of peak systolic velocity (PSV) and end diastolic velocity (EDV), were performed. According to thyroid scintigraphy results, patients were divided into two groups: 42 patients with Graves’ disease and 27 patients with thyroiditis. Results PSV and EDV of both STA and ITA were significantly higher in patients with Graves’ disease than thyroiditis ( p -values <0.001). The STA-PSV had an equal sensitivity and specificity of 66.7%; cut-off value 76.57 cm/s, while those of STA-EDV were 73.8%, and 77.8% respectively; cut-off value 28.22 cm/s. ITA-PSV had a sensitivity and specificity of 76.2% and 77.8%, respectively; cut-off value 62.12 cm/s), while those of ITA-EDV were 78.6% and 77.8%, respectively; cut-off value 5.22 cm/s. Conclusion CDU parameters of the STA and ITA could be used as an alternative to thyroid scintigraphy for discriminating between Graves’ disease and thyroiditis.

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Section: Discussionmentioning

confidence: 99%

Duplex Hemodynamic Parameters of Both Superior and Inferior Thyroid Arteries in Evaluation of Thyroid Hyperfunction Disorders

Hussein¹,

Hamid²,

Samie³

et al. 2022

IJGM

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“…CDUS can be clinically applied for the differential diagnosis of benign and malignant thyroid nodules, as it has high sensitivity and specificity [23][24][25][26][27][28]. Papini et al [24] prospectively evaluated the predictive value of CDUS in 494 patients and reported that intranodular vascular spots (odds ratio, 14.23) were an independent risk factor of malignancy.…”

Section: Diagnosis Of Focal Thyroid Nodulesmentioning

confidence: 99%

“…In summary, CDUS shows acceptable diagnostic performance and may be useful for predicting malignant thyroid nodules. Marked intranodular vascularity on CDUS is a significant predictor of malignancy in thyroid nodules [23][24][25][26][27][28][29][30].…”

Section: Diagnosis Of Focal Thyroid Nodulesmentioning

confidence: 99%

“…Marked internal vascularity on CDUS and SMI may be a major finding of malignant thyroid nodules [23][24][25][26][27][28][29][30][54][55][56]. The emerging modality of SMI can reveal more vascular details than CDUS or PDUS [33][34][35].…”

Section: Summary Consensus and Limitationsmentioning

confidence: 99%

“…They also demonstrated that marked intranodular vascularity was more commonly observed in large thyroid nodules than in small malignant or benign thyroid nodules (P=0.01 for malignant nodules and P=0.001 for benign nodules) [ 27 ]. In a recently published meta-analysis of 20 studies, CDUS showed a pooled sensitivity of 74% (95% confidence interval [CI], 62%-83%) and a pooled specificity of 70% (95% CI, 56%-81%) for the diagnosis of malignant nodules and an area under the curve (AUC) of 0.78 (95% CI, 0.74-0.81) on summary receiver operating characteristic (ROC) curve analysis [ 23 ]. In summary, CDUS shows acceptable diagnostic performance and may be useful for predicting malignant thyroid nodules.…”

Section: Clinical Applications Of Doppler Usmentioning

confidence: 99%

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Clinical applications of Doppler ultrasonography for thyroid disease: consensus statement by the Korean Society of Thyroid Radiology

et al. 2020

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Doppler ultrasonography (US) is widely used for the differential diagnosis of thyroid nodules, metastatic cervical lymph nodes in patients with thyroid cancer, and diffuse parenchymal disease, as well as for guidance in various US-guided procedures, including biopsy and ablation. However, controversies remain regarding the appropriate use and interpretation of Doppler US. Therefore, the Korean Society of Thyroid Radiology organized a taskforce to develop a consensus statement on the clinical use of Doppler US for thyroid disease. The review and recommendations in this article are based on a comprehensive analysis of the current literature and the consensus of experts.

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Preoperative evaluation of thyroid nodules – Diagnosis and management strategies

Antonia,

Maria,

Ancuta-Augustina

2023

Pathology - Research and Practice

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Color Doppler ultrasonography diagnostic value in detection of malignant nodules in cysts with pathologically proven thyroid malignancy: a systematic review and meta-analysis

Cited by 6 publications

References 50 publications

Duplex Hemodynamic Parameters of Both Superior and Inferior Thyroid Arteries in Evaluation of Thyroid Hyperfunction Disorders

Duplex Hemodynamic Parameters of Both Superior and Inferior Thyroid Arteries in Evaluation of Thyroid Hyperfunction Disorders

Clinical applications of Doppler ultrasonography for thyroid disease: consensus statement by the Korean Society of Thyroid Radiology

Preoperative evaluation of thyroid nodules – Diagnosis and management strategies

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