Color Doppler signals from breast tumors. Work in progress.

Cosgrove, David O.; Bamber, Jeffrey C.; Davey, Jane B.; McKinna, J A; Sinnett, H. D.

doi:10.1148/radiology.176.1.2191364

Cited by 183 publications

(101 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Patients can be categorized into three groups based on tumor blood flow measurements: (1) a group with very little flow heterogeneity, i.e., healthy breasts (2.7% variation, n ¼ 2); (2) a group wherein the flow increased up to 230% of that of healthy tissue, i.e., malignant tumors (n ¼ 2); and (3) a group wherein a moderate flow increase up to 153% was observed, i.e., benign tumors (n ¼ 3). These results were in qualitative agreement with previous Doppler ultrasound and PET [60][61][62][63][64][65] results where ∼470 550% increases in blood flow were reported in malignant tumors with smaller contrasts in benign cases. 63 It is clearly demonstrated from the findings above that robust flow contrasts in palpable tumors can be detected by DCS.…”

supporting

confidence: 92%

Near-infrared diffuse correlation spectroscopy in cancer diagnosis and therapy monitoring

2012

J. Biomed. Opt.

View full text Add to dashboard Cite

Abstract. A novel near-infrared (NIR) diffuse correlation spectroscopy (DCS) for tumor blood flow measurement is introduced in this review paper. DCS measures speckle fluctuations of NIR diffuse light in tissue, which are sensitive to the motions of red blood cells. DCS offers several attractive new features for tumor blood flow measurement such as noninvasiveness, portability, high temporal resolution, and relatively large penetration depth. DCS technology has been utilized for continuous measurement of tumor blood flow before, during, and after cancer therapies. In those pilot investigations, DCS hemodynamic measurements add important new variables into the mix for differentiation of benign from malignant tumors and for prediction of treatment outcomes. It is envisaged that with more clinical applications in large patient populations, DCS might emerge as an important method of choice for bedside management of cancer therapy, and it will certainly provide important new information about cancer physiology that may be of use in diagnosis.

show abstract

supporting

confidence: 92%

Near-infrared diffuse correlation spectroscopy in cancer diagnosis and therapy monitoring

2012

J. Biomed. Opt.

View full text Add to dashboard Cite

show abstract

“…In the first studies it was emphasized as signals were more numerous and stronger in breast tumors [1,2]. Now we know that this is not true in all instances [3,4].…”

Section: Introductionmentioning

confidence: 99%

Has color Doppler a role in the evaluation of mammary lesions?

Busilacchi

Draghi

Preda

et al. 2012

Journal of Ultrasound

View full text Add to dashboard Cite

KEYWORDSColor Doppler; Breast; Mammary lesions.Abstract Has color Doppler a role in the evaluation of mammary lesions? A schematic review of color Doppler diagnostic criteria, indicating a benign or malignant lesion, are described. Malignant tumors have a tendency to show increased vascularization, but avascular tumors may be found as well as hypervascular benign tumors. Number of vessels, blood-flow velocity, and intra-tumoral vessel resistance assessed by color Doppler ultrasonography don't permit clear differentiation between malignant and benign tumors, but intra-tumoral blood-flow analysis well correlates with aggressiveness and histological grade of the mass, so a preoperative assessment using Color Doppler may give preliminary prognostic informations useful for therapeutic planning. Color Doppler ultrasound may be valuable also in assessing the efficacy of neoadjuvant chemotherapy and in particular of antiangiogenesis treatments. Color Doppler ultrasound has many other useful applications in the evaluation of diseases of the female and male breast, that are reviewed in the paper. Color Doppler however is not conceived as a stand-alone examination, but associated with Bmode ultrasound that is quite effective as a diagnostic tool, often not requiring Doppler informations.Sommario Il color Doppler ha un ruolo nella valutazione delle lesioni mammarie? Viene presentata una rassegna schematica dei criteri diagnostici color Doppler, che indicano la benignità o la malignità di una lesione. I tumori maligni hanno la tendenza a mostrare vascolarizzazione aumentata, ma si possono trovare tumori maligni avascolari, così come tumori benigni ipervascolarizzati. Numero di vasi, velocità del flusso, indici di resistenza non consentono una sicura differenziazione tra tumori maligni e benigni, ma l'analisi del flusso intratumorale si correla bene con l'aggressività ed il grado istologico della neoplasia, quindi una valutazione preoperatoria, utilizzando il Color Doppler, può fornire informazioni prognostiche preliminari utili per la pianificazione terapeutica. * Corresponding author.E-mail address: giabusil@tin.it (P. Busilacchi). Può essere utile anche per valutare l'efficacia della chemioterapia neoadiuvante e, in particolare di trattamenti antiangiogenesi. Il color Doppler ha molte altre applicazioni nella valutazione delle patologie della mammella femminile e maschile, che vengono esaminati nel presente articolo. Il color Doppler, tuttavia, non è concepito come un esame autonomo, ma associata all'ecografia B-mode, che è molto efficace come strumento diagnostico delle lesioni mammarie e che, spesso, non richiede informazioni Doppler. ª

show abstract

“…Visualization, mapping, and quantification of the blood flow within and surrounding tumors may provide a means for differentiating between benign and malignant masses Cosgrove et al 1990Cosgrove et al , 1993Delorme et al 1995;Kedar et al 1995Kedar et al , 1996Lee et al 1996;Peters-Engl et al 1998;Vaupel et al 1989). Extension into 3D may further improve the ability of discriminating between benign and malignant masses (Carson 1997).…”

Section: Introductionmentioning

confidence: 99%

Rapid 3D Imaging of Contrast Flow: Demonstration of a Dual Beam Technique

Chen

Fowlkes

Carson

et al. 2007

Ultrasound in Medicine & Biology

View full text Add to dashboard Cite

Perfusion imaging in a 3D volume using ultrasound contrast agent may improve vascular characterization compared to 2D imaging. Conventional 3D acquisition requires excessive scan time. A dual transducer technique using conventional systems has been introduced that allows 3D imaging of contrast dynamics with drastically reduced scan times (LeCarpentier et al. 2003). Two transducers are translated across a volume where the leading transducer effects contrast clearance and the following transducer images at desired contrast refill times. With 2D arrays that allow simultaneous clearance and imaging pulses, scan times could be further reduced and the need for two transducers eliminated. The dual transducer technique was demonstrated on a tube phantom, with observed contrast profiles matching those expected. Measured center velocities of (±std dev) 1.46±0.21 and 2.25±0.5 did not statistically differ from expected values of 1.75 and 2.50 (all mm/ s), (p>0.05). This technique is introduced for rapid acquisition of 3D contrast refill images.

show abstract

Color Doppler signals from breast tumors. Work in progress.

Cited by 183 publications

References 0 publications

Near-infrared diffuse correlation spectroscopy in cancer diagnosis and therapy monitoring

Near-infrared diffuse correlation spectroscopy in cancer diagnosis and therapy monitoring

Has color Doppler a role in the evaluation of mammary lesions?

Rapid 3D Imaging of Contrast Flow: Demonstration of a Dual Beam Technique

Contact Info

Product

Resources

About