Color Doppler Imaging and Spectral Analysis of the Optic Nerve Vasculature in Glaucoma

Rankin, Simon J. A.; Walman, Brenda E.; Buckley, Anne; Drance, Stephen M.

doi:10.1016/s0002-9394(14)72771-0

Cited by 189 publications

(137 citation statements)

References 21 publications

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“…(Table 3, 4). These results were consistent with previous reports on POAG Rankin et al 1995;Sergott et al 1994;Yamazaki & Hayamizu 1995). However, for patients with early glaucoma, we could only detect a significantly decreased PSV in nasal PCA as compared with normal subjects, implicating that hemodynamic alteration in glaucoma may occur earlier in the ciliary circulation than in the retinal circulation.…”

Section: Discussionsupporting

confidence: 93%

“…By means of CDI, decreased flow velocity and increased vascular resistance in the central retinal artery (CRA) and posterior ciliary arteries (PCA) have also been identified for patients with POAG and NTG (Butt et al 1995;Harris et al 1994;Rankin et al 1995;Sergott et al 1994;Yamazaki & Hayamizu 1995). In addition, either spontaneous or artificial elevation of intraocular pressure (IOP) was associated with decreased flow velocity and increased resistive index in the CRA and PCA (Harris et al 1996;Liu et al 1997;Trible & Anderson 1998).…”

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confidence: 99%

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Variations in ocular hemodynamics in patients with early and late glaucoma

Liu

Chiou

Chiang

et al. 1999

Acta Ophthalmologica Scandinavica

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ABSTRACT.Purpose: To determine the retrobulbar hemodynamics in glaucoma patients with different degrees of optic nerve damage. Methods: Color Doppler imaging was performed in 52 patients with controlled primary open angle glaucoma (POAG) and in 25 control subjects. Glaucomatous eyes were divided into early and late groups based on the perimetry findings. Peak systolic velocity (PSV), end diastolic velocity (EDV), and resistive index of the central retinal artery (CRA) and posterior ciliary arteries (PCA) were evaluated. Results: Early glaucoma showed significantly decreased PSV in nasal PCA when compared with the normal. Late glaucoma showed significantly decreased PSV and EDV in the CRA and nasal PCA, and significantly decreased PSV in temporal PCA as compared with the control and early glaucoma. The resistive index of the CRA also increased significantly in late glaucoma. Conclusion: Eyes with advanced glaucomatous optic neuropathy were associated with more marked alterations in retrobulbar circulation than eyes with less nerve damage.

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Section: Discussionsupporting

confidence: 93%

mentioning

confidence: 99%

Variations in ocular hemodynamics in patients with early and late glaucoma

Liu

Chiou

Chiang

et al. 1999

Acta Ophthalmologica Scandinavica

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“…Our OA data tends to indicate an increase in PSV and a decrease in EDV in the diabetic groups compared to controls. A decrease in EDV suggests downstream impedence (Rankin et al 1995), while an increase in PSV may be associated with increases in systolic blood pressure . It has previously been shown by Williamson that SBP is positively correlated with PSV in the OA and CRA in normals.…”

Section: Discussionmentioning

confidence: 99%

Colour Doppler imaging of the ocular circulation in diabetic retinopathy

MacKinnon

McKillop

O’Brien

et al. 2000

Acta Ophthalmologica Scandinavica

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ABSTRACT.Purpose: To measure blood flow velocity in the ophthalmic artery (OA) and central retinal artery (CRA) in patients with diabetic retinopathy. Subjects and Methods: 62 age-matched subjects divided into 3 groups: nondiabetic controls (nΩ17); diabetics with no clinical retinopathy or background changes (nΩ24); diabetics with either pre-proliferative or proliferative retinopathy (nΩ21). Colour Doppler imaging was performed on supine patients by one masked observer using the Acuson 128 machine.

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“…Using colour Doppler imaging a decreased end diastolic and an increased peak systolic blood flow velocity as well as an increased resistive index were found in the ophthalmic, central retinal and short posterior ciliary arteries in POAG and especially in NPG patients compared with controls [7][8][9][10][11].…”

Section: Introductionmentioning

confidence: 99%

Scanning laser Doppler flowmetry in glaucoma

1996

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Scanning laser Doppler flowmetry is a new means for the measurement of capillary perfusion. We studied the retinal and neuroretinal rim capillary perfusion with the Heidelberg Retina Flowmeter in one randomly selected eye of 31 healthy volunteers, 42 primary open angle glaucoma (POAG) patients and 17 normal pressure glaucoma (NPG) patients. The reproducibility of the measurements on the temporal and nasal retina and on the disc rim was 19%, 26% and 28% in the unselected control group, 12% in the POAG and 12%, 13% and 10% in the NPG group, respectively. Optic disc flow was significantly higher than retinal flow (p < 0.000001). Differences in corresponding flow values between healthy volunteers and glaucoma patients as well as between POAG and NPG patients were not statistically significant. There was no correlation between the temporal and nasal flow values of the same eyes. The average variation in flow between adjacent frame positions was 18.5%. Actual intraocular pressure and the type of treatment had no influence on the retinal flow. The results suggest that the position of the test-frame is very important for the final result. We could not find any significant difference in the perfusion between glaucomatous and control eyes with the Heidelberg Retina Flowmeter.

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Color Doppler Imaging and Spectral Analysis of the Optic Nerve Vasculature in Glaucoma

Cited by 189 publications

References 21 publications

Variations in ocular hemodynamics in patients with early and late glaucoma

Variations in ocular hemodynamics in patients with early and late glaucoma

Colour Doppler imaging of the ocular circulation in diabetic retinopathy

Scanning laser Doppler flowmetry in glaucoma

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