Color Discrimination Performance in Patients with Alzheimer’s Disease

Salamone, Giovanna; Lorenzo, C.D. Prendes; Mosti, Serena; Lupo, F.A.; Cravello, Luca; Palmer, Katie; Musicco, Massimo; Caltagirone, Carlo

doi:10.1159/000218366

Cited by 56 publications

(48 citation statements)

References 47 publications

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“…The findings of the present study come to agreement with Salamone et al (2009), who described that visual disturbances in Alzheimer's disease patients are not due to global cognitive decline but dependent on the damage caused to the primary visual cortex.…”

Section: Discussionsupporting

confidence: 93%

Dendritic Pathology and Spinal Loss in the Visual Cortex in Alzheimer's Disease: A Golgi Study in Pathology

Mavroudis

Fotiou

Manani

et al. 2011

International Journal of Neuroscience

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Alzheimer's disease is a neurodegenerative disorder characterized by progressive decline in memory, loss of professional skills, impairment of judgement and behavior, and decline in social performances. In terms of neuropathology, the morphological hallmarks of the disease are the accumulation of alpha-beta peptide and the neurofibrillary degeneration, associated with synaptic alterations, involving mostly the dendritic spines. This study is based on the morphological analysis of 10 brains, 5 of which were obtained from patients who suffered from Alzheimer's disease and 5 from nondemented senile individuals used as control group. The segments taken in major from the occipital lobe were studied with the use of Golgi method, as well as Gallyas' and Bielschowski' s staining methods. In most of the pyramidal cells in the affected brains, there seems to be important spine loss and extensive dendrite pathology. Apical dendrites are distorted and tortuous. Horizontal dendritic arborization is severely decreased leading to an amputated, bell-shaped cell soma. Senile plaques have been often revealed, and neurofibrillary changes have also been noticed.

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Section: Discussionsupporting

confidence: 93%

Dendritic Pathology and Spinal Loss in the Visual Cortex in Alzheimer's Disease: A Golgi Study in Pathology

Mavroudis

Fotiou

Manani

et al. 2011

International Journal of Neuroscience

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“…Dementia is linked to hearing impairment and some recent work appears to show that hearing impairment can substantially increase the risk of incident dementia (Lin et al, 2011). Not surprising, visual sensory impairments were also linked with dementia (Adlington, Laws, & Gale, 2009;Salamone et al, 2009), with a possible impact on selective attention performance (Tewari, Shakuf, & van Lieshout, 2014).…”

Section: Intellectual Functions (B117)mentioning

confidence: 99%

Untitled

Heinrich¹,

Gagné

Viljanen

et al. 2016

SIIW

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Successful communication is vital to active aging and well-being, yet virtually all older adults find it challenging to communicate effectively in noisy environments. The resulting discomfort and frustration can prompt withdrawal or avoidance of social situations, which, in turn, can severely limit the range of activities available to older adults and lead to a less active and satisfying lifestyle, and, in some cases, depression. Using the International Classification of Functioning, Disability and Health's (ICF) multifactorial model (WHO, 2001), we review the wider aspects of functioning and disability as they relate to hearing difficulties and communication, placing a particular emphasis on the work we, an international and interdisciplinary group of researchers, have done in the context of the ERA-NET funded interdisciplinary HEARATTN project. The ICF model is particularly fitting because it allows us to consider how physiological changes in hearing and cognition affect listening in various situations, what the consequences of these changes are for communicative abilities and social participation, and how this in turn affects life-space mobility, self-reported well-being, and, ultimately, quality of life. We will discuss how environmental conditions (both physical and social) and personal factors can affect how well older adults can communicate in the situations characteristic of everyday life. In the concluding section we discuss some behaviours, techniques and strategies that can be adopted to maintain or improve effective communication under difficult listening conditions.

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“…They also found a significant association between motion threshold and disease severity. However, while some studies have found impairment of detection of motion [11] and impairment of low spatial frequencies [10], many studies have found other visual deficits, including impairment of color (blue-yellow), backward masking, and contrast sensitivity at all frequencies, which cannot be explained by the broad-band pathway deficit [59,60,[68][69][70]. This suggests that it is not only the broad-band pathway which is affected by AD, although it may be a contributory factor in the visual deficits seen in AD.…”

Section: Neuropsychological Studiesmentioning

confidence: 99%

Visual Impairment in Alzheimer's Disease: A Critical Review

Kirby

Bandelow

Hogervorst

2010

JAD

102

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Visual impairment is a common symptom of Alzheimer's disease (AD). Recent studies have demonstrated the potential of visual interventions to improve the functioning of AD patients. Therefore, clarification of the profile of visual deficits in AD and possible mechanisms underlying these deficits are needed. This review focuses on three areas as mechanisms for the visual impairment in AD: 1) the broad-band pathway deficit; 2) glaucoma; and 3) the relative dysfunction of the ventral and dorsal streams of vision. While much research has been produced with regard to these areas, methodological flaws and lack of continuity between studies has led to conflicting findings. Nevertheless, recent imaging research suggests that the loss of retinal ganglion cells in AD may play an important role in the visual deficit in AD. This review looks to critically evaluate current research and highlight the need to investigate recent significant findings in primary vision research in understanding the impairment of vision in AD.

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Color Discrimination Performance in Patients with Alzheimer’s Disease

Cited by 56 publications

References 47 publications

Dendritic Pathology and Spinal Loss in the Visual Cortex in Alzheimer's Disease: A Golgi Study in Pathology

Dendritic Pathology and Spinal Loss in the Visual Cortex in Alzheimer's Disease: A Golgi Study in Pathology

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Visual Impairment in Alzheimer's Disease: A Critical Review

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