Color Change of Sudan III against Concentrated Sulfuric Acid in Acetonitrile and Quantification for a Small Amount of Concentrated Sulfuric Acid

Sakurai, Takao; Kurata, Shoji; Ogino, Kenji

doi:10.2116/analsci.32.129

Cited by 1 publication

(1 citation statement)

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“…Sudan III is a water-insoluble dye and the presence of an azo group (−NN−) in them allows the extension of π-electron conjugation and is responsible for the intense absorption of electromagnetic radiation in the visible region . The λ max of Sudan III dye generally lies in the range of 500–515 nm depending on the organic solvent used. − The λ max value of Sudan III dye solubilized in aqueous AMT solution (100 mmol kg –1 ) is found to be 512 nm, which is relatively comparable to the observed λ max value in the literature. , Solubilization of Sudan III dye in the drug micelles was studied to rationalize the aggregation of AMT. Figure depicts the visible spectra obtained for solubilization of Sudan III dye in the AMT micellar solutions prepared in the studied mixed media.…”

Section: Resultssupporting

confidence: 55%

Self-Assembly and Thermodynamic Parameters of Amitriptyline Hydrochloride in Polar Organic Solvent–Water Mixed Media

Gurung

Pulikkal

2019

J. Chem. Eng. Data

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Organic solvent–water mixed media find applications in industrial, chemical, and pharmaceutical areas. This work discusses the micellization and related parameters such as degree of counterion dissociation (α), change in Gibbs energy of micellization (ΔG m 0) of an amphiphilic drug amitriptyline hydrochloride (AMT), and Gordon parameter (G p) in three polar organic solvents, viz., ethanol (EtOH), ethylene glycol (EG), and glycerol (GL)–water mixed media, with a special focus on the effects of a wide range of polarity changes. A decrease in conductivity of the solution and an enhancement of critical micelle concentration (cmc) of AMT are found with the increase in weight percentage (wt %) of the organic solvents in their mixed media at a pH of 6.7 and a temperature of 303.15 K. The cmc and absorbance values evaluated from conductivity and dye solubilization measurements, respectively, reveal that the GL–water mixed media behave as a better system for AMT compared to the EG–water and EtOH–water mixed media. The calculated values for ΔG m 0 in all the compositions of the mixed media were negative, which increase with the increase in wt % of the studied organic solvents.

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