Color Atlas of Histopathology of the Cervix Uteri

Abstract

The new edition of this atlas integrates all significant advances made in the past 15 years in molecular pathology, tumor virology, and genetics of cervical cancer. It emphasizes the importance of these advances in facilitating its pathological diagnosis and in optimizing clinical management and prognosis. A new chapter on immunohistochemistry has been added, which includes refined detection methods, e.g., the overexpression of p16INK4a as a molecular marker in the early differential diagnosis of premalignant lesions. The section on etiology and pathogenesis in human papillomavirus-induced neoplasia has been incorporated to represent new insights into the sequences of cellular and nuclear deregulation at the molecular level. All chapters have been revised to include the newest advances and relevant experiences in how to interpret and manage cervical disease; they are supported by the addition of 35 new microphotographic illustrations. The tumor nomenclature is adapted to the latest edition of the WHO classification; the morphology code of the international classification of diseases for oncology (ICD-O) has been added. We have also updated the list of references by adding recent relevant publications.Again, the staff of Springer-Verlag deserve our thanks for their patience and skill in preparing the manuscript and in reproducing the microphotographs. Preface to the First Edition During the past decade our understanding of the histopathology of the cervix uteri has changed greatly. Because of the lifestyles of the modern permissive society, cervical viral infections have become epidemic, resulting in inflammatory and precancerous lesions that were uncommon but now are seen mainly in the younger age groups with increasing frequency. Then too, progress in molecular biology and immunohistochemistry has enabled us to distinguish subtypes of papilloma viruses, to proceed in understanding their action within the genome, and to trace the infected metaplastic and neoplastic-transformed cells to their histogenetic origins. The resultant refined classification of cervical neoplasias has helped to predict clinical outcome and to choose type of therapy.This atlas is intended for all pathologists, to aid them in their routine diagnostic work. We hope it explains just how comprehensive, important and complex the histopathology of the cervix uteri has become during the last few years. It covers all pertinent differential diagnostic aspects and describes in detail how to reach the correct diagnosis. The atlas is also meant for the clinician, to guide him in his often difficult decision of how to provide optimal care for the frequently young patient, who desires children but is at risk for cancer. In particular, the atlas is designed to foster an improved dialogue between the pathologist and the clinician.The microphotographs were selected from our daily diagnostic material, since they show best the technical variations confronting the clinical pathologist in his daily routine, where effects of specimen transport, differences in ...

A patient derived xenograft model of cervical cancer and cervical dysplasia

“…Generated tumours were invasive but metastases were rare in our model. We demonstrated for the first time that cervical dysplasia tissues generate microscopic cystic growth under the murine renal capsule showing features expected of dysplasia for key markers of cervical cancer [ 30 ]. Similarly, we demonstrated for the first time that the NSG renal capsule permitted the survival and microscopic growth of normal human cervical tissue in vivo .…”

Neuroendocrine differentiation in a case of cervical cancer

“…Second, neuroendocrine carcinomas are inherently more aggressive than their squamous counterparts and are managed with different protocols [12]. Expression of chromogranin A, synaptophysin, and various other proteins involved in the formation of neurosecretory granules or CD 56, a neural cell adhesion molecule, can be used as markers of neuroendocrine differentiation, as in neuroendocrine carcinomas of other organs [13].…”

Screening of Cervical Cancer: Visual Inspection with Acetic Acid (VIA) and Site of Lesion Verified by Multiple Punch Biopsies

“…The gynecologist took multiple biopsy samples from all women with and without lesions from 6 and 12 o'clock in the normal cervix transformation zone. For the multiple punch biopsies, the pathologist evaluated mild cervical intraepithelial neoplasia (CIN1), or moderate CIN2 or severe CIN3 according to Dallenbach-Hellweg et al 13 criteria:…”