Infectious Disease Clinics of North America volume 25, issue 4, P803-817 2011 DOI: 10.1016/j.idc.2011.07.007 View full text
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Andrea V. Page, W. Conrad Liles

Abstract: Colony-stimulating factors (CSFs) are attractive adjunctive anti-infective therapies. Used to enhance innate host defenses against microbial pathogens, the myeloid CSFs increase absolute numbers of circulating innate immune effector cells by accelerating bone marrow production and maturation, or augment the function of those cells through diverse effects on chemotaxis, phagocytosis, and microbicidal functions. This article summarizes the evidence supporting the accepted clinical uses of the myeloid CSFs in pat…

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