Colonoscopic Screening of First-Degree Relatives of Patients With Large Adenomas: Increased Risk of Colorectal Tumors

Colorectal Cancer Screening: Recommendations for Physicians and Patients from the U.S. Multi-Society Task Force on Colorectal Cancer

“…First-degree relatives with advanced adenomas are recommended to be weighted the same as fi rst-degree relatives with CRC ( Table 5 ). Th e yield of colonoscopic screening in fi rst-degree relatives of persons with advanced adenomas is substantially increased (129)(130)(131).…”

Impact of Comorbidity on Colorectal Cancer Screening Cost-Effectiveness Study in Diabetic Populations

“…For the simulated trials, we used person-specific data from the 1998-2004 NHANES survey to create a simulated 24 Villavicencio et al 48 Johns et al 49 Cottet et al 50 Giovannucci et al 51 Effects of gender, family history, BMI and diabetes are represented by hazard ratios derived from author-conducted meta-analysis.…”

Genetic dissection of intermediate phenotypes as a way to discover novel cancer susceptibility alleles

“…For example, colorectal adenomas and inflammatory bowel disease are conditions with a strong genetic component and have more or less proven associations with colorectal cancer (CRC) risk [34][35][36][37]. First-degree relatives of colorectal adenoma cases are at an increased risk of adenoma and CRC (relative risk, RR = 2.27 and 1.56, respectively [38]) and patients with ulcerative colitis (UC) have a CRC risk that is nearly six times higher than that in the general population [39]. Interestingly, recent GWA studies have identified common risk factors for CRC, colorectal polyps and UC.…”