Colonoscopic screening is associated with reduced Colorectal Cancer incidence and mortality: a systematic review and meta-analysis

Abstract

It is the great priority to detect colorectal cancer (CRC) as early as possible, finally to reduce the incidence and mortality of CRC. However, although colonoscopy is recommended in many consensuses, yet no one systematic review is conducted to figure out how colonoscopy could change the incidence and mortality. In our study, we conducted a comprehensive meta-analysis to evaluate the association between colonoscopy screening and the incidence or mortality of CRC. PubMed, EMBASE, and PMC database were systematically searched from their inception to June 2020. A total of 13 cohort and 16 case-control studies comprising 4,713,778 individuals were obtained in this review. Our results showed that colonoscopy was associated with a 52% RR reduction in incidence of CRC (RR: 0.48, 95% CI: 0.46-0.49) and 62% RR reduction in mortality of CRC (RR: 0.38, 95% CI: 0.36-0.40). Subgroup analysis of different interventions, study design, country, sample size, age or sex showed that the incidence and mortality reduction remained consistent, and colonoscopy screening had the same effect on people below and above 50. Our study indicated that colonoscopy could significantly reduce the incidence and mortality of CRC.

A Review of Colonoscopy in Intestinal Diseases

“…However, these three case–control studies were unable to determine indications for colonoscopy, and excluded colonoscopies performed within 6 months of CRC diagnosis, likely introducing bias. In a meta-analysis conducted with 13 cohorts including 4,713,778 individuals and 16 case–control studies, colonoscopy screening not only reduced the incidence of colorectal cancer by 52% (risk ratio (RR): 0.48, 95% CI, 0.46–0.49), but also reduced colorectal cancer related mortality by 62% (RR: 0.38, 95% CI, 0.36–0.40) [ 110 ]. Flexible sigmoidoscopy and colonoscopy are both recommended CRC screening strategies, but their relative effectiveness is unclear.…”

Effect of multidisciplinary collaborative empowerment education on psychological distress and quality of life in patients with colorectal cancer undergoing chemotherapy

“…In China, CRC is the second most common type of cancer and the leading cause of cancer-associated mortality [ 2 ]. The incidence of CRC has increased with the aging of the population and lifestyle changes in recent years [ 3 ]. Despite advances in the understanding of cancer biology and extensive exploitation for clinical treatment, adjuvant chemotherapy remains the current standard of treatment for patients with colorectal cancer.…”

The Diagnostic Power of Circulating miR-1246 in Screening Cancer: An Updated Meta-analysis

“…Despite improvements in diagnosis and treatment, cancer is still burdened disease globally with the increased new cases and deaths over the years [1,2]. Annual screening and earlier detection are crucial strategies that help to reduce cancer incidence and mortality [3][4][5][6][7]. Moreover, early detection of cancers leads to the use of less-aggressive interventions that improve patients' quality of life.…”