Colonoscopic Findings in Peruvian Patients with Chronic Diarrhea

Villafuerte-Gálvez, Javier; Sotelo-Olivera, María Isabel; Cok, Jaime; Piscoya, Alejandro; Huerta-Mercado, Jorge

doi:10.1371/journal.pone.0046690

Cited by 8 publications

(8 citation statements)

References 9 publications

(15 reference statements)

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“…This observation indicates that colonoscopy is a safe procedure done in all age groups and can be biopsied for further evaluation. The sex and age incidence were in concordance with studies done by Shah et al 11 & Galvez V J et al 3 All the 100 cases were presented with diarrhea (bloody and non-bloody) along with other coexisting symptoms like pain abdomen (37%), weight loss (24%) and fatigue (8%), while the study done by Shah et al 11 showed associated findings like pain abdomen (43%), weight loss (9%), rectal bleeding (27%) and anaemia (15%).…”

Section: Discussionsupporting

confidence: 91%

“…The present study reported 12 cases as tuberculosis commonest granulomatous lesion in India having male to female ratio of 2:1 mostly occurring at 40-60 years age group. The findings are akin to the studies done by Villa fuerte G J et al 3 Pulimood A et al 15 and Kirsch R et al 16 Ulcerative colitis though rare is emerging disease in India this condition portrays remission and relapses. In the present study, 9 cases of UC were diagnosed with a male to female ratio of 2:1 and occurring at the age group of 20-40 years which are comparable to done by Deroche et al, 17 Shah et al 11 described 7 cases of ulcerative colitis in their colonoscopic study of 168 cases.…”

Section: Discussionsupporting

confidence: 71%

“…In developing countries chronic bacterial, mycobacterial infection, and parasitic infestation are the most common causes of chronic diarrhoea whereas in developed countries, irritable bowel syndrome, inflammatory bowel disease, malabsorption syndrome, and chronic infections are the most common causes. [3][4][5][6][7] Colonoscopy has been used to evaluate the large bowel, to screen colorectal diseases especially neoplasia and polyps 4,8,9 Colonoscopy visualizes the mucosa of the colon rectum and upto terminal ileum and checks for macroscopic lesions. Additionally, several procedures can be performed, especially biopsies.…”

Section: Introductionmentioning

confidence: 99%

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Histomorphological study of colonoscopic biopsies in patients presenting with chronic diarrhea

Kabbur

Vidya²,

K³

2021

ACHR

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: Colonoscopic biopsy is an important tool in the diagnosis of large bowel diseases affected by a wide range of conditions both non neoplastic and neoplastic which can present with chronic diarrhea. The causes for chronic diarrhoea vary depending on socio-economic factors, hygienic practices. Studies exploring the causes of chronic diarrhea in developing countries are few, with no generalized uniformity. With this background information the present study is planned to know various causes of chronic diarrhea by histopathological study. To assess the histopathological findings among colonoscopic biopsies in patients undergoing work up for chronic diarrhea and to deternine the sex and age incidence in major causes: A total of 100 colonoscopic biopsies from the patients suffering from chronic diarrhea were obtained from the Department of Medical Gastroenterology and received in the Department of Pathology, VIMS & RC Bangalore from January 2014 to January 2015 were studied.: In the present study 100 colonoscopic biopsies were studied with a mean age of 45 years and male to female ratio of 3.3:1. Out of 100 cases, 92 cases were non-neoplastic lesions, 3 cases were benign and 5 cases were malignant lesions. Among 92 cases, majority of them were inflammatory lesions accounting to 85 cases (92.4%), 4 (4.3%) cases were polypoid lesions. The inflammatory bowel disease were more commonly seen in 31-40 years with the male preponderance.: Colonoscopy biopsy is a useful investigation to be carried out in patients with chronic diarrhea for proper diagnosis and treatment. It has a role in diagnosis, follow up and treatment, especially in cases of inflammatory bowel disease and malignancies. It is the gold standard for cancer surveillance.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionsupporting

confidence: 71%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Histomorphological study of colonoscopic biopsies in patients presenting with chronic diarrhea

Kabbur

Vidya²,

K³

2021

ACHR

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“…Summary of evidence: The frequency of MC in patients with chronic or intermittent watery diarrhoea and a macroscopically normal (or near normal) colon has been evaluated in several studies 17 ,. 18 , 21 , 26 , 27 , 42–72 Based on studies with a moderate or high quality, and a sample size of ≥100 patients, 17,18,21,26,27,42,43,45–47,49,52,54,56,59,60 the pooled overall frequency of MC was estimated to be 12.8% (95% CI: 9.9–15.9, I 2 = 93.6%). The pooled frequency of CC and LC was 4.96% (95% CI: 3.6–6.5, I 2 = 85.2%) 17,18,21,26,27,42,43,45,47,49,52,54,56,60 and 8.2% (95% CI: 6.0–10.8, I 2 = 92.0%), 17,18,21,26,27,42,43,45,47,49,52,54,56,60 respectively (see also Supporting Information Appendix ).…”

Section: Methodsmentioning

confidence: 99%

European guidelines on microscopic colitis: United European Gastroenterology and European Microscopic Colitis Group statements and recommendations

et al. 2021

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Introduction Microscopic colitis is a chronic inflammatory bowel disease characterised by normal or almost normal endoscopic appearance of the colon, chronic watery, non-bloody diarrhoea and distinct histological abnormalities, which identify three histological subtypes, the collagenous colitis, the lymphocytic colitis and the incomplete microscopic colitis. With ongoing uncertainties and new developments in the clinical management of microscopic colitis, there is a need for evidence-based guidelines to improve the medical care of patients suffering from this disorder. Methods Guidelines were developed by members from the European Microscopic Colitis Group and United European Gastroenterology in accordance with the Appraisal of Guidelines for Research and Evaluation II instrument. Following a systematic literature review, the Grading of Recommendations Assessment, Development and Evaluation methodology was used to assess the certainty of the evidence. Statements and recommendations were developed by working groups consisting of gastroenterologists, pathologists and basic scientists, and voted upon using the Delphi method. Results These guidelines provide information on epidemiology and risk factors of microscopic colitis, as well as evidence-based statements and recommendations on diagnostic criteria and treatment options, including oral budesonide, bile acid binders, immunomodulators and biologics. Recommendations on the clinical management of microscopic colitis are provided based on evidence, expert opinion and best clinical practice. Conclusion These guidelines may support clinicians worldwide to improve the clinical management of patients with microscopic colitis.

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“…[ 9 ] Despite the use of invasive colonoscopy in chronic diarrhea, the majority of macroscopic findings are unremarkable. [ 10 ] The most common causes include irritable bowel syndrome, IBD, microscopic colitis, and malabsorption syndromes. [ 11 ] Infection is an uncommon cause of chronic diarrhea.…”

Section: Introductionmentioning

confidence: 99%

Challenges in the diagnosis of ulcerative colitis with concomitant bacterial infections and chronic infectious colitis

Lin¹,

Chang²,

Chen³

et al. 2017

PLoS ONE

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Ulcerative colitis (UC) is a chronic inflammation of the large bowel characterized by diarrhea and a negative stool culture. However, several enteropathogens have been implicated as causative agents in UC. The differentiation between chronic infectious colitis (IC) and UC with concurrent infection is difficult owing to their similar clinical presentations. The study aimed to explore the presentations and diagnostic clues that enable differentiation between UC with concomitant infections and chronic IC. The study included 17 UC patients with a bacterial infection and 46 with chronic IC. The UC patients (47 ± 19 years) were younger than the chronic IC patients (58 ± 20 years) (P = 0.022). Bloody diarrhea was more common in UC than in chronic IC (58.8% vs 10.9%, P < 0.001). Previous antibiotic usage was a risk factor for chronic IC (5.9% vs 32.6%, P = 0.031). Malignancy was a common comorbidity of chronic IC (5.9% vs 34.8%, P = 0.022). UC patients had lower antibiotic response rates than chronic IC patients (60.0% vs 87.2%, P = 0.026). Aeromonas species and Clostridium difficile were common in both groups. Histological features of cryptitis and crypt abscess were useful in the diagnosis of UC (P = 0.052 and P = 0.016, respectively). Bloody diarrhea in a young adult, decreased response to antibiotic treatment, and results of endoscopy with biopsy are important features in the diagnosis of UC with bacterial infection.

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Colonoscopic Findings in Peruvian Patients with Chronic Diarrhea

Cited by 8 publications

References 9 publications

Histomorphological study of colonoscopic biopsies in patients presenting with chronic diarrhea

Histomorphological study of colonoscopic biopsies in patients presenting with chronic diarrhea

European guidelines on microscopic colitis: United European Gastroenterology and European Microscopic Colitis Group statements and recommendations

Challenges in the diagnosis of ulcerative colitis with concomitant bacterial infections and chronic infectious colitis

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