Colonoscopic Fecal Bacteriotherapy in the Treatment of Recurrent Clostridium Difficile Infection - Results and Follow-up

Mellow, Mark H.; Kanatzar, Amy

doi:10.14309/00000434-201010001-00367

Cited by 24 publications

(38 citation statements)

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“…From all 105 positive faecal samples C. difficile was isolated and strains were assigned to 22 different C. difficile PCR ribotypes. The five most frequent ribotypes were 027 (57), 014/ 020 (6), 081 (6), 002 (5) and 023 (5).…”

Section: Resultsmentioning

confidence: 99%

Gut Microbiota Patterns Associated with Colonization of Different Clostridium difficile Ribotypes

et al. 2013

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C. difficile infection is associated with disturbed gut microbiota and changes in relative frequencies and abundance of individual bacterial taxons have been described. In this study we have analysed bacterial, fungal and archaeal microbiota by denaturing high pressure liquid chromatography (DHPLC) and with machine learning methods in 208 faecal samples from healthy volunteers and in routine samples with requested C. difficile testing. The latter were further divided according to stool consistency, C. difficile presence or absence and C. difficile ribotype (027 or non-027). Lower microbiota diversity was a common trait of all routine samples and not necessarily connected only to C. difficile colonisation. Differences between the healthy donors and C. difficile positive routine samples were detected in bacterial, fungal and archaeal components. Bifidobacterium longum was the single most important species associated with C. difficile negative samples. However, by machine learning approaches we have identified patterns of microbiota composition predictive for C. difficile colonization. Those patterns also differed between samples with C. difficile ribotype 027 and other C. difficile ribotypes. The results indicate that not only the presence of a single species/group is important but that certain combinations of gut microbes are associated with C. difficile carriage and that some ribotypes (027) might be associated with more disturbed microbiota than the others.

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Section: Resultsmentioning

confidence: 99%

Gut Microbiota Patterns Associated with Colonization of Different Clostridium difficile Ribotypes

et al. 2013

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“…(1,2) Should relapse occur the risk of further recurrence then rises to 40-50%. (3) In addition CDI has increased in both incidence and severity globally. (4,5) The suboptimal nature of CDI management has driven the search for alternative therapies.…”

Section: Adverse Events In Faecal Microbiota Transplant (Fmt) a Reviementioning

confidence: 99%

Adverse events in faecal microbiota transplant: a review of the literature

Baxter

Colville

2016

Journal of Hospital Infection

155

122

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“…When multiple publications related to the same patient group, 11,[23][24][25][26][27][28][29][30][31][32][33][34][35] the most complete data were analysed. 11,24,26,28,30,32,35 Individual patient information was extracted from each study. The following information was retrieved: (i) characteristics of patients (including number of patients, age, gender and disease types); (ii) characteristics of intervention (including delivery method, route of instillation, relationship between the recipients and the donors); (iii) type of outcome measures (included duration of follow-up, change in frequency and severity of symptoms, resolution, treatment failure, relapse, death et al); (iv) safety outcomes included any adverse events associated with the FMT procedure.…”

Section: Data Extraction and Synthesismentioning

confidence: 99%

Systematic review: faecal microbiota transplantation therapy for digestive and nondigestive disorders in adults and children

Sha

Liang

Chen

et al. 2014

Aliment Pharmacol Ther

120

109

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Colonoscopic Fecal Bacteriotherapy in the Treatment of Recurrent Clostridium Difficile Infection - Results and Follow-up

Cited by 24 publications

References 0 publications

Gut Microbiota Patterns Associated with Colonization of Different Clostridium difficile Ribotypes

Gut Microbiota Patterns Associated with Colonization of Different Clostridium difficile Ribotypes

Adverse events in faecal microbiota transplant: a review of the literature

Systematic review: faecal microbiota transplantation therapy for digestive and nondigestive disorders in adults and children

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