Colonization resistance against multi-drug-resistant bacteria: a narrative review

Guern, Rémi Le; Stabler, Sarah; Gosset, Philippe; Pichavant, Muriel; Grandjean, Teddy; Faure, Emmanuel; Karaca, Yilmaz; Faure, Karine; Kipnis, Éric; Dessein, Rodrigue

doi:10.1016/j.jhin.2021.09.001

Cited by 14 publications

(7 citation statements)

References 125 publications

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“…Table 2 compiles studies showing the effects of probiotic supplementation on GM and biochemical markers in workers. In fact, they could be used in a personalized way for everyone under the concept of precision probiotics [75].…”

Section: Use Of Probiotics To Restore Dysbiosis In Workersmentioning

confidence: 99%

Effects of Unconventional Work and Shift Work on the Human Gut Microbiota and the Potential of Probiotics to Restore Dysbiosis

et al. 2023

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The work environment is a factor that can significantly influence the composition and functionality of the gut microbiota of workers, in many cases leading to gut dysbiosis that will result in serious health problems. The aim of this paper was to provide a compilation of the different studies that have examined the influence of jobs with unconventional work schedules and environments on the gut microbiota of workers performing such work. As a possible solution, probiotic supplements, via modulation of the gut microbiota, can moderate the effects of sleep disturbance on the immune system, as well as restore the dysbiosis produced. Rotating shift work has been found to be associated with an increase in the risk of various metabolic diseases, such as obesity, metabolic syndrome, and type 2 diabetes. Sleep disturbance or lack of sleep due to night work is also associated with metabolic diseases. In addition, sleep disturbance induces a stress response, both physiologically and psychologically, and disrupts the healthy functioning of the gut microbiota, thus triggering an inflammatory state. Other workers, including military, healthcare, or metallurgy workers, as well as livestock farmers or long-travel seamen, work in environments and schedules that can significantly affect their gut microbiota.

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Section: Use Of Probiotics To Restore Dysbiosis In Workersmentioning

confidence: 99%

Effects of Unconventional Work and Shift Work on the Human Gut Microbiota and the Potential of Probiotics to Restore Dysbiosis

et al. 2023

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“…Alteration of the gut microbiota by antibiotics (clindamycin) was required to overcome colonisation resistance provided by the healthy gut microbiota and allow successful CPE colonisation, as previously described 12 . Indeed, mice exposed to CPE only (without antibiotics) were not colonised 14 days after CPE exposure and presented a gut microbiome similar to control mice.…”

Section: Discussionmentioning

confidence: 99%

Gut colonisation with multidrug-resistant Klebsiella pneumoniae worsens Pseudomonas aeruginosa lung infection

et al. 2023

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Carbapenemase-producing Enterobacterales (CPE) are spreading rapidly in hospital settings. Asymptomatic CPE gut colonisation may be associated with dysbiosis and gut-lung axis alterations, which could impact lung infection outcomes. In this study, in male C57BL/6JRj mice colonised by CPE, we characterise the resulting gut dysbiosis, and analyse the lung immune responses and outcomes of subsequent Pseudomonas aeruginosa lung infection. Asymptomatic gut colonisation by CPE leads to a specific gut dysbiosis and increases the severity of P. aeruginosa lung infection through lower numbers of alveolar macrophages and conventional dendritic cells. CPE-associated dysbiosis is characterised by a near disappearance of the Muribaculaceae family and lower levels of short-chain fatty acids. Faecal microbiota transplantation restores immune responses and outcomes of lung infection outcomes, demonstrating the involvement of CPE colonisation-induced gut dysbiosis in altering the immune gut-lung axis, possibly mediated by microbial metabolites such as short-chain fatty acids.

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“…In this context, infection prevention and control are critical to prevent the spread of multidrug-resistant bacteria. E. coli as a common pathogen of bacterial diseases can incorporate drug-resistant genes into other bacteria by means of horizontal transmission and vertical transmission, thus creating more drug-resistant strains ( Moritz et al, 2020 ; Le Guern et al, 2021 ). The resistance mechanism of MRSA is that the binding protein has a very low affinity with antibacterial drugs, which can promote the synthesis of bacterial cell wall.…”

Section: Discussionmentioning

confidence: 99%

Green synthesis of silver nanoparticles through oil: Promoting full-thickness cutaneous wound healing in methicillin-resistant Staphylococcus aureus infections

Wang

Peng

et al. 2022

Front. Bioeng. Biotechnol.

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Due to the emergence of multi-drug resistant microorganisms, the development and discovery of alternative eco-friendly antimicrobial agents have become a top priority. In this study, a simple, novel, and valid green method was developed to synthesize Litsea cubeba essential oil-silver nanoparticles (Lceo-AgNPs) using Lceo as a reducing and capping agent. The maximum UV absorbance of Lceo-AgNPs appeared at 423 nm and the size was 5–15 nm through transmission electron microscopy result. The results of Fourier transform infrared and DLS showed that Lceo provided sufficient chemical bonds for Lceo-AgNPs to reinforce its stability and dispersion. The in vitro antibacterial effects of Lceo-AgNPs against microbial susceptible multidrug-resistant Escherichia coli (E. coli) and methicillin-resistant Staphylococcus aureus (MRSA) were determined. The minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) of Lceo-AgNPs against E. coli were 25 and 50 μg/ml. The MIC and MBC of Lceo-AgNPs against MRSA were 50 and 100 μg/ml, respectively. The results of scanning electron microscopy showed that the amount of bacteria obviously decreased and the bacteria cells were destroyed by Lceo-AgNPs. In vivo research disclosed significant wound healing and re-epithelialization effects in the Lceo-AgNPs group compared with the self-healing group and the healing activity was better than in the sulfadiazine silver group. In this experiment, Lceo-AgNPs has been shown to have effects on killing multidrug-resistant bacteria and promoting wound healing. This study suggested Lceo-AgNPs as an excellent new-type drug for wound treatment infected with multidrug-resistant bacteria, and now expects to proceed with clinical research.

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Colonization resistance against multi-drug-resistant bacteria: a narrative review

Cited by 14 publications

References 125 publications

Effects of Unconventional Work and Shift Work on the Human Gut Microbiota and the Potential of Probiotics to Restore Dysbiosis

Effects of Unconventional Work and Shift Work on the Human Gut Microbiota and the Potential of Probiotics to Restore Dysbiosis

Gut colonisation with multidrug-resistant Klebsiella pneumoniae worsens Pseudomonas aeruginosa lung infection

Green synthesis of silver nanoparticles through oil: Promoting full-thickness cutaneous wound healing in methicillin-resistant Staphylococcus aureus infections

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