Colonization of Mice by<i>Candida albicans</i>Is Promoted by Chemically Induced Colitis and Augments Inflammatory Responses through Galectin‐3

Jawhara, Samir; Thuru, Xavier; Standaert-Vitse, Annie; Jouault, Thierry; Mordon, Serge; Sendid, Boualem; Desreumaux, Pierre; Poulain, Daniel

doi:10.1086/528990

Cited by 161 publications

(179 citation statements)

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“…Defects in the C-type lectin, β-glucan receptor dectin-1 -which plays a fundamental role in antifungal immunity by β-glucan yeast wall component recognition [162] and which deficiency in humans causes fungal infection susceptibility [50] -confer increased susceptibility to chemically induced colitis, disease that could be exacerbated by repeated oral delivery of C. tropicalis [160]. This was consistent with the report that C. albicans could also exacerbate DSSinduced colitis [163] and that an indigenous Candida population could drive disease. Similarly, lung responses generated via the β-glucan receptor dectin-1 are required for lung defense during acute, invasive A. fumigatus infection through IL-22 production [164].…”

Section: Microorganisms and The Immune System Exhibit Crosstalk Betwesupporting

confidence: 82%

Richness and diversity of mammalian fungal communities shape innate and adaptive immunity in health and disease

2014

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Human holobiomes are networks of mutualistic interactions between human cells and complex communities of bacteria and fungi that colonize the human body. The immune system must tolerate colonization with commensal bacteria and fungi but defend against invasion by either organism. Molecular ecological surveys of the human prokaryotic microbiota performed to date have revealed a remarkable degree of bacterial diversity and functionality. However, there is a dearth of information regarding the eukaryotic composition of the microbiota. In this review, we describe the ecology and the human niches of our fungal "fellow travelers" in both health and disease, discriminating between passengers, colonizers, and pathogens based on the interaction of these fungi with the human immune system. We conclude by highlighting the need to reconsider the etiology of many fungal and immune-related diseases in the context of the crosstalk between the human system and its resident microbial communities.Keywords: Dysbiosis r Fungal metagenomics r Host-microbe interaction r Mycobiota IntroductionHumans live in close association with a complex community of bacteria, viruses, fungi, and archaea [1][2][3], which inhabit their bodies. Many groups have surveyed these microbial populations using the so-called "next generation" or "deep" sequencing approaches, revealing that the human microbiota differs radically at various body sites and among individuals [2][3][4]. The differences in the human microbiota are influenced by the availability of nutrients, environmental exposure to microorganisms, and other sitespecific features, such as the immunological makeup of a given location. The origin of differences in the microbiota between individuals potentially reflects different patterns of colonization early in life (reviewed in [5]), different dietary regimens [6,7], and different environmental exposures, such as antibiotic use [8,9]. Recently, the application of deep sequencing approaches have genCorrespondence: Dr. Duccio Cavalieri e-mail: duccio.cavalieri@fmach.it erated novel hypotheses about the microbial determinants underlying human disorders of immune origin (reviewed in [10]). Several metabolites of the interaction between diet and host microbiota, such as short-chain fatty acids, have been shown to play a fundamental role in shaping immune responses (reviewed in [11]). The application of microbial ecology concepts is ultimately leading to the conclusion that health and disease can be understood only through an understanding of the ways in which the symbiotic interactions between microbes and human organs harmonically integrate in the context of the hologenome [12].Human microbial diversity is not limited to bacteria; microorganisms such as fungi also play major roles in the stability of microbial communities in human health and disease (reviewed in [13]). Yeasts were detected in human stool samples as far back as 1917, and by the mid-20th century the presence of yeasts in the human intestine was proposed to have a saprotrophic role [14]....

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Section: Microorganisms and The Immune System Exhibit Crosstalk Betwesupporting

confidence: 82%

Richness and diversity of mammalian fungal communities shape innate and adaptive immunity in health and disease

2014

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“…The increasing incidence of Crohn's disease and other inflammatory bowel diseases, which previously were only prevalent in populations with a strong genetic component, is also an important factor [77][78][79][80][81][82][83][84][85][86].…”

Section: Drugs and Prolonged Use Of Antibioticsmentioning

confidence: 99%

Candidiasis: Predisposing Factors, Prevention, Diagnosis and Alternative Treatment

et al. 2014

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SUMMARYCandidiasis is the most common opportunistic yeast infection. Candida species and other microorganisms are involved in this complicated fungal infection, but Candida albicans continues to be the most prevalent. In the past two decades, it has been observed an abnormal overgrowth in the gastrointestinal, urinary and respiratory tracts, not only in immunocompromised patients, but also related to nosocomial infections and even in healthy individuals. There is a widely variety of causal factors that contribute to yeast infection which means that candidiasis is a good example of a multifactorial syndrome. Due to rapid increase in the incidence of these infections, this is the subject of numerous studies. Recently, the focus of attention is the treatment and, above all, the prevention of those complications. The diagnosis of candidiasis could become quite complicated. Prevention is the most effective "treatment", much more than eradication of the yeast with antifungal agents. There are several aspects to consider in the daily routine that can provide a strength protection. However, a therapeutic approach is necessary when the infection is established and, therefore, other alternatives should be explored. This review provides an overview on predisposition factors, prevention and diagnosis of candidiasis, highlighting alternative approaches for candidiasis treatment.

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“…This contrasts with the results from at least two independent groups that demonstrated ASCA generation in mice colonized with C. albicans [29,30]. Indeed considering the relation between CD and anti-yeast mannan antibodies, it appears that according to the data accumulated over decades in basic and medical mycology C. albicans would be a more convincing suspect for CD triggering and/or maintenance than S. cerevisiae .…”

mentioning

confidence: 68%

Uric acid levels are independent of anti-Saccharomyces cerevisiae antibodies (ASCA) in Crohn’s disease: A reappraisal of the role of S. cerevisiae in this setting

et al. 2018

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Colonization of Mice byCandida albicansIs Promoted by Chemically Induced Colitis and Augments Inflammatory Responses through Galectin‐3

Abstract: DSS-induced colitis provides a model for establishing C. albicans colonization in mice. This model reveals that C. albicans augments inflammation and confirms the role of Gal-3 in both inflammation and the control of host responses to C. albicans.

Cited by 161 publications

References 43 publications

Richness and diversity of mammalian fungal communities shape innate and adaptive immunity in health and disease

Richness and diversity of mammalian fungal communities shape innate and adaptive immunity in health and disease

Candidiasis: Predisposing Factors, Prevention, Diagnosis and Alternative Treatment

Uric acid levels are independent of anti-Saccharomyces cerevisiae antibodies (ASCA) in Crohn’s disease: A reappraisal of the role of S. cerevisiae in this setting

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