Colonization of America by Drosophila Subobscura: Spatial and Temporal Lethal-gene Allelism

Solé, Elisabet; Mestres, Francesc; Balanyà, Joan; Arenas, C.; Serra, Luı́s

doi:10.1111/j.1601-5223.2000.00065.x

Cited by 13 publications

(42 citation statements)

References 33 publications

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“…The similarity between North and South America Our analysis of the Odh gene confirms the high degree of genetic resemblance between North and South American populations previously demonstrated in other studies Balanyà et al 1994;Rozas and Aguadé 1991;Mestres et al 1990;Solé et al 2000). All O 5 chromosomal lines have the same haplotype in both North and South America.…”

Section: Discussionsupporting

confidence: 71%

“…In American populations lethal genes do not distribute at random among the different chromosomal arrangements , in some cases being significantly associated with particular arrangements. This is the case for the complete association observed between the O 5 inversion and a lethal gene and for the partial association between the O 3+4+7 chromosomal arrangement and another lethal gene (Mestres et al 1990;Solé et al 2000). These associations were found in both North and South American populations suggesting that the colonizations were not independent (Mestres et al 1992).…”

Section: Introductionmentioning

confidence: 82%

“…The Bellingham collection was obtained in 1991 and 13 lethal chromosomal lines have been analyzed. The Centralia population was sampled in 1995 (Solé et al 2000) and 11 lethal chromosomal lines have been sequenced. Furthermore, two lethal chromosomal lines (both carrying the O 5 inversion) from the Chilean population of Puerto Montt (Mestres et al 1990) and 3 from Santiago de Chile (Mestres et al 1992) were analyzed.…”

Section: Methodsmentioning

confidence: 99%

“…As the O 5 inversion is not very common and has a rather erratic distribution in the Old World Krimbas, 1993;Mestres et al 1994;Zivanovic and Mestres 2000), it is likely that only one O 5 inversion (carrying the lethal gene) was included in the initial sample of colonizers . The significant latitudinal clines of the frequency of this inversion observed in colonizing populations (Prevosti et al 1985;1990) together with its complete association with a lethal gene (Mestres et al 1990;, Solé et al 2000 and its significant persistence in America (Mestres et al 2001), make it especially suitable to study not only the origin of the colonization, but also some of the evolutionary consequences of this event.…”

Section: Introductionmentioning

confidence: 99%

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Colonization of America by Drosophila subobscura: Association between Odh gene haplotypes, lethal genes and chromosomal arrangements

et al. 2004

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The colonization of America by Drosophila subobscura has been a unique experiment in nature that has allowed us to explore the effects of evolution on a continental scale. To analyze this evolutionary event, nucleotide sequences of the Odh (Octanol dehydrogenase) gene were obtained for 43 lethal chromosomal lines from colonizing populations of North America and 5 from South America, in addition to 5 chromosomal lines from Europe with different viabilities and 2 from laboratory marker stocks. Since 10 different Odh haplotypes were found in America, the minimum number of colonizers would be 5 (or 3 mated females). Only one Odh haplotype was found in American O 5 inversions confirming that only one copy of this inversion was included among the sample of colonizers. The same Odh haplotypes were detected in association with the same chromosomal arrangements and with identical lethal genes in both North and South America indicating that exactly the same chromosome types reached both hemispheres. These observations indicate that the two continental colonizations are not independent. They are derived from the same colonization event. The population from which the colonization started should contain the O 5 inversion, a non-negligible frequency of the O 3+4+7 arrangement and all other arrangements found in America. So far the only populations that fulfill all these requirements are those from Greece, indicating that these populations can be considered good candidates as a starting point for an in depth analysis of the origin of the American colonization by D. subobscura .

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Section: Discussionsupporting

confidence: 71%

Section: Introductionmentioning

confidence: 82%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Colonization of America by Drosophila subobscura: Association between Odh gene haplotypes, lethal genes and chromosomal arrangements

et al. 2004

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“…In the present study, the following North and South American colonizing populations have been used: Gilroy (37°00Ј N), Davis (38°33Ј N), and Eureka (40°49Ј N) (California); Medford (42°20Ј N) and Salem (44°57Ј N) (Oregon); Centralia (46°43Ј N) and Bellingham (48°45Ј N) (Washington); Santiago de Chile (33°30Ј S), Laja (37°10Ј S), Valdivia (39°46Ј S), Puerto Montt (41°28Ј S) and Coihaique (45°35Ј S) (Chile); Bariloche (41°11Ј S) (Argentina). The relevant data of these populations can be found in previous articles (8)(9)(10)(11)(12).…”

Section: Methodsmentioning

confidence: 99%

Colonization of America byDrosophila subobscura: Heterotic effect of chromosomal arrangements revealed by the persistence of lethal genes

Mestres

Balanyà

Arenas

et al. 2001

Proc. Natl. Acad. Sci. U.S.A.

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About 20 years ago Drosophila subobscura, a native Palearctic species, colonized both North and South America. In Palearctic populations lethal genes are not associated in general with particular chromosomal arrangements. In colonizing populations they are not randomly distributed and usually are associated to a different degree with chromosomal arrangements caused by the founder event. The persistence of two lethal genes in the colonizing populations, one completely associated with the O5 inversion and the other partially associated with the O3؉4؉7 arrangement, has been analyzed. In all populations studied (five North American and six South American) the observed frequency of the lethal gene completely associated with the O5 inversion is higher than expected, the difference being statistically significant in all South American and one North American populations. The observed frequency of the lethal gene partially associated with the O3؉4؉7 arrangement is also significantly higher than expected. Taking into account that the O5 inversion exhibits significant latitudinal clines both in North and South America, an overdominant model favoring the heterokaryotypes seems to be in operation. From this model, a polynomial expression has been developed that allows us to estimate the relative fitness and the coefficient of selection against all karyotypes not carrying the O5 inversion. The relative fitness of the O5 heterokaryotypes is higher in South American than in North American populations. Furthermore, the observed frequencies of the lethal genes studied are in general very close to those of the equilibrium. This case is an outstanding demonstration in nature of an heterotic effect of chromosomal segments associated with lethal genes on a large geographic scale.

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GEVA: geometric variability-based approaches for identifying patterns in data

et al. 2009

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This paper, arising from population studies, develops clustering algorithms for identifying patterns in data. Based on the concept of geometric variability, we have developed one polythetic-divisive and three agglomerative algorithms.\ud The effectiveness of these procedures is shown by relating them to classical clustering algorithms. They are very general since they do not impose constraints on the\ud type of data, so they are applicable to general (economics, ecological, genetics…)\ud studies. Our major contributions include a rigorous formulation for novel clustering\ud algorithms, and the discovery of new relationship between geometric variability and clustering. Finally, these novel procedures give a theoretical frame with an intuitive interpretation to some classical clustering methods to be applied with any type of data, including mixed data. These approaches are illustrated with real data on Drosophila chromosomal inversions.Postprint (published version

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Colonization of America by Drosophila Subobscura: Spatial and Temporal Lethal-gene Allelism

Cited by 13 publications

References 33 publications

Colonization of America by Drosophila subobscura: Association between Odh gene haplotypes, lethal genes and chromosomal arrangements

Colonization of America by Drosophila subobscura: Association between Odh gene haplotypes, lethal genes and chromosomal arrangements

Colonization of America byDrosophila subobscura: Heterotic effect of chromosomal arrangements revealed by the persistence of lethal genes

GEVA: geometric variability-based approaches for identifying patterns in data

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