Colonization and infection of mothers and neonates with group B streptococci in three Italian hospitals

Visconti, Arianna; Orefici, Graziella; Notarnicola, Angela

doi:10.1016/s0195-6701(85)80129-8

Cited by 9 publications

(5 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The only case of early‐onset disease was caused by type III, a C protein‐negative GBS strain, and occurred in a full‐term neonate born to a lightly colonized mother without risk factors. This is not unusual, since it has been reported that light colonization causes up to 50% of neonatal infections [13,26]. During the study period, the incidence of GBS sepsis was 0.4/1000 live births.…”

Section: Discussionsupporting

confidence: 53%

“…Thirty‐seven GBS strains, isolated from mothers and newborns in the last 6 months of the study, were serotyped according to standard procedures at the WHO Reference Centre for Streptococci and Streptococcal Diseases at the Laboratory of Bacteriology and Medical Mycology of the Istituto Superiore di Sanità, Rome, Italy [13]. Briefly, GBS typing of capsular polysaccharides was carried out by Ouchterlony double agar immunodiffusion.…”

Section: Methodsmentioning

confidence: 99%

“…Data on GBS infection in Italy are scarce [12,13] but an increase in the incidence of such infections has been observed in many hospitals, especially in the last few years [14]. The aim of this study was to evaluate maternal and neonatal colonization of GBS in 2300 mother‐child pairs admitted to the Neonatal and Obstetrics and Gynecology Divisions of Perugia General Hospital from March 1993 to September 1995.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Carriage of group B Streptococcus in pregnant women and newborns: a 2-year study at Perugia General Hospital

Sensini

Tissi

Verducci

et al. 1997

Clinical Microbiology and Infection

View full text Add to dashboard Cite

OBJECTIVE: To study the prevalence of group B Streptococcus (GBS) colonization in pregnant women and their newborns at Perugia General Hospital. METHODS: The number of mother---child pairs examined was 2300. Vaginal swabs were collected from the mothers at delivery, and auricular and pharyngeal swabs and gastric aspirate from the newborns at birth. Maternal risk factors for GBS disease, including premature delivery, intrapartum fever, prolonged rupture of membranes and multiple births, were evaluated. RESULTS: Maternal and neonatal colonization rates were 11.3% and 4.6%, respectively. GBS was isolated in 41.5% of the neonates born to colonized mothers and in 0.1% of those born to non-colonized mothers. No significant difference was observed in vertical transmission rates in the presence or absence of maternal risk factors. The external auditory canal was the most frequent (93.5%) and heavily colonized body site. Type Ib was the most common serotype among GBS isolates from mothers and babies. C surface protein was not detected in serotype V and VIII isolates, but was frequent in all other serotypes. Early-onset disease was observed in 0.4/1000 live births. CONCLUSIONS: The prevalence of maternal and neonatal colonization at Perugia General Hospital was similar to that obtained in other studies performed in Italy. The external auditory canal was confirmed as the most reliable body site to be sampled for the detection of neonates exposed to maternal GBS colonization.

show abstract

Section: Discussionsupporting

confidence: 53%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Carriage of group B Streptococcus in pregnant women and newborns: a 2-year study at Perugia General Hospital

Sensini

Tissi

Verducci

et al. 1997

Clinical Microbiology and Infection

View full text Add to dashboard Cite

show abstract

“…In previous studies, GBS carriage prevalences between 1.6% and 30.4% have been described [2][3][4][5]7,8,[13][14][15][16][17][18][19][20][21][22][23][24][25][26]. The differences in these prevalences can probably be explained by the different gestational ages at culturing, differences in culture site and in the use of different culture techniques.…”

Section: Commentmentioning

confidence: 99%

Prevalence of colonisation with group B Streptococci in pregnant women of a multi-ethnic population in The Netherlands

Berg

Sprij

Oostvogel³

et al. 2006

European Journal of Obstetrics & Gynecology and Reproductiv

View full text Add to dashboard Cite

Objective: This study was performed to determine the prevalence of GBS and to identify GBS colonisation risk factors in a multicultural population of pregnant women in The Netherlands. We calculated predictive values of cultures in pregnancy for intrapartum GBS carriage. Study design: From a total of 1702 women visiting several antenatal outpatient departments, rectovaginal swabs were collected at 35-37 weeks' gestation. In 761 women swabs were repeated at time of delivery. Carriage of GBS late in third trimester and at time of delivery was analysed in relation to age, parity, ethnicity and socio-economic status. Results: Twenty-one percent was GBS carrier late in pregnancy. Compared to Europeans, African women were at a higher risk (29%, RR 1.4, CI 1.1-1.7) and Asian women were at lower risk (13%, RR 0.6, CI 0.4-0.8) for GBS carriage. No differences in colonisation were found between women with respect to age, parity or socio-economic background. Positive predictive value of GBS carriage at 35-37 weeks' gestation for carriage at time of parturition was 79% and negative predictive value was 93%. Conclusions: It was not possible to identify a group of pregnant women at high risk for GBS colonisation. Predictive values of antenatal genital group B streptococci cultures at 35-37 weeks' gestation for intrapartum GBS carriage are lower than previously reported. # 2005 Published by Elsevier Ireland Ltd.

show abstract

“…The risk of neonatal colonization may be higher in women who are stable GBS carriers [33], possibly because these women tend to have a larger bacterial burden. Overall, EOGBS disease is diagnosed in up to 2% of colonized neonates [38,39], with some of the variation between studies probably being dependent on differences in techniques used to ascertain neonatal colonization. In a critical review of literature published before 1998 Benitz et al [35] found that there was a statistically significant gradient of risk with both decreasing gestational age and birth weight.…”

Section: Neonatal Colonization and Eogbs Diseasementioning

confidence: 99%

Current and future strategies for prevention of neonatal early-onset group B streptococcus disease

Milner

Smith

Spicer

et al. 2015

J Pediatr Infect Dis

View full text Add to dashboard Cite

Group B streptococci (GBS) have been recognized as a leading cause of serious early-onset neonatal sepsis for 30 years. Introduction of intrapartum antibiotic prophylaxis (IAP) has led to a decrease in neonatal early-onset GBS (EOGBS) disease and in early neonatal sepsis-related mortality in many countries. At present decisions concerning the administration of IAP are usually based on either the presence of risk factors at the time of labor, or on screening of women at 35-37 weeks gestation. A new generation of rapid test for GBS suitable for point of care use offer the prospect of accurately detecting GBS during labor, which might improve targeting of IAP. Looking further ahead, active immunization of women before or during pregnancy may become the mainstay of prevention of neonatal EOGBS disease. In this article the role of GBS as a neonatal pathogen, and current and possible future strategies for prevention of neonatal EOGBS disease, are reviewed.

show abstract

Colonization and infection of mothers and neonates with group B streptococci in three Italian hospitals

Cited by 9 publications

References 31 publications

Carriage of group B Streptococcus in pregnant women and newborns: a 2-year study at Perugia General Hospital

Carriage of group B Streptococcus in pregnant women and newborns: a 2-year study at Perugia General Hospital

Prevalence of colonisation with group B Streptococci in pregnant women of a multi-ethnic population in The Netherlands

Current and future strategies for prevention of neonatal early-onset group B streptococcus disease

Contact Info

Product

Resources

About