Colonization and infection due to carbapenemase-producing Enterobacteriaceae in liver and lung transplant recipients and donor-derived transmission: a prospective cohort study conducted in Italy

Errico, Giulia; Gagliotti, Carlo; Monaco, Monica; Masiero, Lucia; Gaibani, Paolo; Ambretti, Simone; Landini, Maria Paola; D’Arezzo, Silvia; Di, Antonino; Parisi, Saverio Giuseppe; Palù, Giorgio; Vespasiano, Francesca; Morsillo, Filomena; Moro, Maria Luisa; Procaccio, Francesco; Ricci, A.; Grossi, Paolo; Pantosti, Annalisa; Costa, Alessandro Nanni; Farina, Claudio; Vailati, Francesca; Gesu, Giampietro; Vismara, Chiara; Arghittu, Milena; Colombo, Renzo; Torresani, Erminio; Rossi, Lucía; Conaldi, Pier Giulio; Gona, Floriana; Cambieri, Patrizia; Marone, Piero; Venditti, Carolina; Fernández, Ana; Mancini, Carlo; Cusi, Maria Grazia; Angelis, Lucia Henrici De; Fossati, Lucina; Finarelli, Alba Carola; Cillia, C. De; Sangiorgi, Gabriela; Pinna, Antonio; Stella, Federica; Viale, Pierluigi; Colledan, M.; Platto, Marco; Bonizzoli, Manuela; Peris, Adriano; Torelli, Rosanna; Vesconi, S.; Cibelli, E.; Carlis, Luciano De; Gasperi, Andrea De; Ravini, M.; Carrinola, R.; Coluccio, Elena; Dondossola, Daniele; Rossi, Grazielle Guidolin; Santambrogio, Luigi; Tosi, Davide; Feltrin, Giuseppe; Rago, Carlo; Cillo, Umberto; Riva, Agostino; Rea, Federico; Sparacino, Vito; Bertani, Alessandro; Canzonieri, Marco; Gridelli, Bruno; Mularoni, Alessandra; Spada, Marco; Carrara, E.; D’Armini, Andrea Maria; Paladini, Piero; Adorno, Dominique Persano; Valeri, M; Caprio, M.; Ciaccio, Paola Di; Puoti, Francesca; Berloco, P.B.; D’Auria, B.; Maldarelli, Federica; Paglialunga, G.; Pugliese, F.; Rossi, Marianna; Venuta, Federico; Amoroso, Antonio; Giacometti, R.; Rinaldi, Matteo; Salizzoni, Mauro

doi:10.1016/j.cmi.2018.05.003

Cited by 44 publications

(50 citation statements)

References 27 publications

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“…We implemented a Medline search using the terms “donor derived,” “donor transmitted,” and “donor colonized” combined with the terms “ Klebsiella Pneumoniae ,” “Carbapenem-Resistant Klebsiella Pneumoniae ,” “CRKP,” “extended-spectrum beta-lactamase” and “transplantation.” Nine related published reports during 2011 to 2018 were found, involved 18 patients with donor-derived CRKP infection, consisted of 6 liver recipients, 5 lung recipients, 4 kidney recipients, 1 heart recipient, 1 combined kidney-pancreas recipient, and 1 combined liver-kidney recipient. Among which there were 1 early death (9 days) [6] and 5 late death (≥28 days) postoperation, 1 lost of follow-up after renal allograft loss. [7] Eleven cases of restriction pattern of isolates from donors and recipients were matched confirmed by PFGE analysis while the other 7 cases were highly suspected due to the matched antibiotic susceptibility tests.…”

Section: Cases Presentation and Literature Reviewmentioning

confidence: 99%

Carbapenem-resistant Klebsiella pneumoniae infection causing rupture of graft artery in solid organ recipients

Cai¹,

Xiao²,

Zhang³

et al. 2019

Medicine

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Rationale:Donor-derived bacterial infection is a rare cause of morbidity after solid organ transplantation (SOT) but associated with significant morbidity and mortality, deaths caused by carbapenem-resistant Klebsiella pneumoniae (CRKP) infection account for a considerable proportion of postoperation mortality rate in liver and kidney recipients. The arterial rupture as a result of fungal arteritis is occasionally described, while the rupture of graft vascular anastomosis after SOT due to donor-derived CRKP infection is rarely reported.Patients concerns:We reported 1 patient with donor-derived CRKP infection following liver transplantation and 2 patients following renal transplantation (1 liver and 2 kidneys were from the same donor), who experienced sudden abdominal pain and abdominal hemorrhage almost at the same time after organ transplantation.Diagnosis:The patients were diagnosed as graft arteries rupture due to corrosion caused by CRKP infection based on computed tomography scan, blood culture, laparotomy, and pulse-field gel electrophoresis.Interventions:Anti-shock treatment, exploratory laparotomy, broad-spectrum antibiotics, and abdominal puncture and drainage were given.Outcomes:The liver recipient survived as well as the liver graft, still under treatment of multiple abdominal infections. The 2 renal recipients were alive after resection of the renal grafts and underwent hemodialysis.Lessons:Rupture of graft artery should be foreseen when donor-derived CRKP infection was confirmed and broad-spectrum antibiotics and other interventions need to be considered.

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Section: Cases Presentation and Literature Reviewmentioning

confidence: 99%

Carbapenem-resistant Klebsiella pneumoniae infection causing rupture of graft artery in solid organ recipients

Cai¹,

Xiao²,

Zhang³

et al. 2019

Medicine

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“…26,27 In the case of PCa, the interest in miRNA is linked to the fact that prostate-specific antigen shows several limitations, 28,29 as infection, very common in frail patients. 30,31 Early diagnosis, especially in the high risk, as the main cause of death for PCa, is needed. 32,33 The challenge nowadays is to better understand the mechanism of cancer development, finding real PCa markers and developing new specific therapies in order to reduce the mortality of PCa.…”

Section: Discussionmentioning

confidence: 99%

Identification of Urinary Exosomal miRNAs for the Non-Invasive Diagnosis of Prostate Cancer

Li¹,

Li²,

Diao³

et al. 2021

CMAR

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“…The definitive diagnosis is histopathologic with immunohistochemical analysis. At the histological level, EES appears as poorly differentiated, small round blue cells tumor positive for the transmembrane glycoprotein CD99, vimentin, FLI1, CKAE1/AE3, and CD 117 staining and negative TLE and WT-1 [ 15 , 16 , 17 , 18 ] ( Figure 5 ). The tumor cells have a pale-to-clear scanty cytoplasm and glycogen could be highlighted on PAS staining [ 17 ].…”

Section: Discussionmentioning

confidence: 99%

Metastatic renal Ewing’s sarcoma in adult woman: Case report and review of the literature

et al. 2021

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Primary renal extra-skeletal Ewing sarcoma is a rare neoplasm, often metastatic at diagnosis, and with a poor outcome. A multimodal approach is often the treatment of choice in this aggressive neoplasm. We present a case of primary renal extra-skeletal sarcoma in a 45-year-old woman who underwent tumor resection without clear margins. After no response to the first cycle of chemotherapy, we documented an early onset of local recurrence. The patient refused any other treatment and died four months after surgery.

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Colonization and infection due to carbapenemase-producing Enterobacteriaceae in liver and lung transplant recipients and donor-derived transmission: a prospective cohort study conducted in Italy

Cited by 44 publications

References 27 publications

Carbapenem-resistant Klebsiella pneumoniae infection causing rupture of graft artery in solid organ recipients

Carbapenem-resistant Klebsiella pneumoniae infection causing rupture of graft artery in solid organ recipients

Identification of Urinary Exosomal miRNAs for the Non-Invasive Diagnosis of Prostate Cancer

Metastatic renal Ewing’s sarcoma in adult woman: Case report and review of the literature

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