Colonisation with multidrug-resistant bacteria is associated with increased mortality in patients with cirrhosis

Prediction of 28‐day mortality in acute decompensation of cirrhosis through the presence of multidrug‐resistant infections at admission

“…The reasons for high MDR infections in India as compared with the West could be the higher or abuse/misuse of over‐the‐counter antibiotics in community or higher existence of antibiotics or resistant microorganisms entering in the food chain. A recent study showed the colonization with MDR bacteria in 30% cirrhotics at admission that was an independent predictor of mortality . Very recently, a noninvasive screening for MDRO especially in rectal swabs was shown to antedate the occurrence of MDR SBP with positive predictive and negative predictive value of 77% and 83% at day 30 .…”

The impact of carbapenem resistance on clinical deterioration and mortality in patients with liver disease

“…The global spread of multidrug‐resistant bacteria is attracting scientific attention in recent years . However, less attention has been paid on the impact of colonisation and infection caused by CRGN in patients with liver diseases and especially in cirrhotic patients .…”

“…Multidrug‐resistant non‐fermenting pathogens are globally emerging . The increasing incidence of nosocomial and community‐acquired infections by multidrug‐resistant non‐fermenting CRGN imperils immunocompromised individuals, such as patients suffering from cirrhosis, resulting in significant mortality . Only four (3%) of CRGN were isolated from blood cultures, which shows that sepsis was most frequently culture‐negative.…”

“…Possibly driven by immunological dysfunction, bacterial infections in cirrhotic patients significantly increase mortality compared to non‐cirrhotic patients . Furthermore, even colonisation with MDRGN seems to imperil patients’ prognosis . The incidence of MDRGN‐associated infections in patients with liver diseases has rapidly been increasing in recent years .…”

Comparison of the in vitro susceptibility of rifaximin versus norfloxacin against multidrug resistant bacteria in a hospital setting. A proof-of-concept study for use in advanced cirrhosis: Table 1

“…We read with interest the recent letter to the editor from Waidmann et al 1 investigating the effect of multidrug resistant (MDR) bacteria intestinal colonisation on the prognosis of patients with cirrhosis. The authors concluded that infections due to MDR bacteria and asymptomatic intestinal colonisation with MDR bacteria are a risk factor for mortality in cirrhosis.…”