Colonisation with extended-spectrum β-lactamase-producing Enterobacteriaceae and risk for infection among patients with solid or haematological malignancy: a systematic review and meta-analysis

Urinary tract infections caused by ESBL‐producing Enterobacteriaceae in renal transplant recipients: A systematic review and meta‐analysis

“…Concerning the geographic distribution of our findings, studies included in our analysis covered most continents, and demonstrated increased ESBL‐PE rates in South America and Asia compared to Europe and North America. These results parallel those of previous aggregate studies performed in both healthy and high‐risk populations . The observed differences probably reflect the different antimicrobial usage and infection control policies employed in the various parts of the world .…”

Colonization with extended‐spectrum beta‐lactamase‐producing Enterobacteriaceae in solid organ transplantation: A meta‐analysis and review

“…The colonization rate noted in our analysis is higher than the colonization rate reported in healthy individuals (18% vs 14%) and comparable to that reported in patients with malignancy (18% vs 19%) . This high prevalence can be attributed to specific aspects of the management of SOT patients; these patients are frequently exposed to anti‐infective agents, for both therapeutic and prophylactic purposes, and increased antimicrobial use has been associated with selection of ESBL‐E .…”

Drug‐resistant organisms are common in fecal surveillance cultures, predict bacteremia and correlate with poorer outcomes in patients undergoing allogeneic stem cell transplants

“…Since there is only a small window of opportunity for treating febrile neutropenia in the severely immunocompromised host, the absence of timely and appropriate antibiotic intervention is one of the limiting factors in improvement of outcomes in the post‐transplant setting. Fecal surveillance culture has been used to guide empiric antibiotic therapy in the immunosuppressed setting but data have been conflicting, with most studies not showing a correlation between fecal colonizers and subsequent bacteremia …”