Colonic Wall Redundancy at CT in Patients with Cystic Fibrosis

Abstract

Proximal colonic wall redundancy is seen frequently in adults with CF and may be more common in those with non-DeltaF508 CFTR gene mutations. This finding provides a starting point for further investigation of the molecular basis of colonic phenotype in CF.

Imaging findings of colonic wall redundancy in cystic fibrosis patients: two case reports

“…Moreover, Patient 2 showed homogenous hyperdensity of the appendix. After contrast medium injection, the inner wall showed a marked hypervascularity, perhaps related to acute or chronic colonic mucosal inflammation, as reported by Webb et al [1].…”

“…The symptoms of these conditions are nonspecific. The most common symptom is recurrent abdominal pain, with or without intestinal obstruction [1,5,6].…”

“…This condition can also be associated with pericolonic edema [1], and can be easily detected with imaging techniques.…”

“…The term colonic wall redundancy (CWR) was used for the first time by Webb et al in 2008 to describe a condition also called jejunization of the colon [1]. This is a frequent condition in adult cystic fibrosis (CF) patients, is probably chronic, and usually asymptomatic or associated with nonspecific gastrointestinal symptoms that can affect all or some parts of the colon.…”

“…This condition should be differentiated from colitis, ileocolic intussusception, and other colonic pathologies frequently seen in adult CF patients [1].…”