Colonic transit time in long-term dialysis patients

Functional bowel disorders and associated risk factors in hemodialysis patients in Turkey

“…FBDs were found in 22 (27.5%) patients; thus, FBDs were statistically significantly increased in the patient group than in the control group (p=0.01). Functional constipation is a common problem in HD patients (19), and its prevalence is known to be 53% (20). In a study in HD patients, chronic constipation was found in 40% of patients and chronic diarrhea was found in 24% of patients (2).…”

“…In our study, the prevalence of functional constipation was found to be higher in HD patients than in the controls. The reasons for this situation may be an intake of foods containing low fiber, vitamin C, and potassium (28); the use of excess ion-exchange resin (1); and prolonged total colonic transit time (19).…”

Role of Gut-Derived Protein-Bound Uremic Toxins in Cardiorenal Syndrome and Potential Treatment Modalities

“…85 In addition, the production of gut-derived solutes is further accelerated by the prolonged colonic transit time that is commonly observed in long-term hemodialysis patients. 86 Strategies to modify colonic microbiome include probiotic, fibrosis, enhanced TGF-β1 and phosphorylated NF-κB protein expression and increased cardiac oxidative stress; 47,48 all of these findings were attenuated by an IS-lowering agent AST-120. IS-induced cardiac fibrosis appears to be mediated via the ROS/ NF-κB/TGF-β1 pathway, similar to renal fibrosis caused by IS.…”

Medication Side Effects: Barriers to the Management of Fluid Intake

“…18,19 Intestinal motility is greatly reduced for those who are on hemodialysis, with transit times 3 times longer than for people not on dialysis. 20 The sensation of having a dry mouth, a condition known as xerostomia, is quite common among older people and those with diabetes. 21,22 It is noted that this can at Although patients are ultimately responsible for their fl uid intake, it is clear that many of their medications greatly impact their ability to effectively do so.…”