Colonic subepithelial myofibroblasts in mucosal inflammation and repair: contribution of bone marrow-derived stem cells to the gut regenerative response

Andoh, Akira; Bamba, Shigeki; Fujiyama, Yoshihide; Brittan, Mairi; Wright, Nicholas

doi:10.1007/s00535-005-1727-4

Cited by 75 publications

(76 citation statements)

References 81 publications

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“…Therefore, the PE animal model was not used to investigate the immunosuppressive and repair capacity of MSCs in vivo. Recently, several groups have reported that treatment with human MSCs can attenuate the progression of experimental colitis induced by DSS [32,40,41]. We confirmed that oral administration of 3% DSS for 8 days (Fig.…”

Section: Mir-181a Expression Impairs Msc-based Therapy For Experimentsupporting

confidence: 83%

MicroRNA‐181a Regulates Local Immune Balance by Inhibiting Proliferation and Immunosuppressive Properties of Mesenchymal Stem Cells

et al. 2012

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Section: Mir-181a Expression Impairs Msc-based Therapy For Experimentsupporting

confidence: 83%

MicroRNA‐181a Regulates Local Immune Balance by Inhibiting Proliferation and Immunosuppressive Properties of Mesenchymal Stem Cells

et al. 2012

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“…MSC immune-suppressive activity is localized at the sites of inflammation and regulated by cells and factors present in local microenvironment, indicating that greater MSCs homing and infusion close to inflamed sites may enhance therapeutic results (32). Previous studies showed marrow cells differentiate into colonic subepithelial myofibroblasts (SEMFs) and produce pro-inflammatory cytokines and might cause inflammation to flare up (33). In contrast, it was documented that exogenously administered MSCs themselves might have an anti-inflammatory effect before differentiation into various types of cells.…”

Section: Discussionmentioning

confidence: 99%

“…Fibrosis is typically associated with mesenchymal cell hyperplasia, tissue disorganization and fibrillar collagen deposition. The transient appearance of activated myofibroblasts is a feature of normal wound healing that disappears by apoptosis at the end of the normal repair process, but the persistence of these cells is associated with excessive collagen deposition and fibrosis (33,35). In subgroup IIIb very fine collagen fibers in between the crypts were recorded.…”

Section: Discussionmentioning

confidence: 99%

The Possible Role of Mesenchymal Stem Cells Therapy in the Repair of Experimentally Induced Colitis in Male Albino Rats

et al. 2013

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Background and Objectives: Colitis is inflammation of the colon which can be transmural or confined to the mucosa. Colitis may be acute or chronic. In case of serious intestinal discontinuity of epithelium, the regeneration capacity of local stem cells is not enough to complete tissue repair. Bone marrow mesenchymal stem cells (BM-MSCs) migrate into the gastrointestinal wall, where they may contribute to the repair progress. The present study aimed at evaluating the possible therapeutic effect of MSCs on induced colitis in albino rat. Methods and Results: Twenty male albino rats were divided into 3 groups (control, colitis, MSCs), control group (4 rats), colitis group (8 rats) received once intra-rectal injection of 2 ml of 3% acetic acid. MSCs therapy group (8 rats) injected with MSCs 24 hours after colitis induction. In each group, rats were subdivided into subgroups (a & b). Subgroup (a) corresponds to rats sacrificed 3 days and subgroup (b) corresponds to rats sacrificed 10 days after colitis induction. Isolation and culture of MSCs from rat bone marrow were performed. Colon sections were examined using light and fluorescent microscopy. Colon specimens were subjected to histological, morphometric and statistical studies. In colitis group, ulceration, loss of surface columnar epithelium, disturbed crypts architecture with few goblet cells and huge lymphatic nodule piercing the muscularis mucosa were reported. In stem cell therapy group, MSCs stimulate colonic repair through differentiation into several cells and dampen the inflammation. Conclusions: MSCs represent future therapeutic hopes for intestinal injury and chronic intestinal inflammatory states.

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“…Similar effects are known to occur in other regenerative cell types. In subepithelial myofibroblasts, the expression of MMP-3 is induced by TGF-β during repair processes in the gastrointestinal mucosa [35]. Comparably, in synovial fibroblasts, TGF-β regulates the expression of MMP-3 and MMP-10 [2].…”

Section: Discussionmentioning

confidence: 99%

The TGF-β1-Induced Expression of Matrix Metalloproteinases in Mesenchymal Stromal Cells is Influenced by Type of Substrate

Warstat

Felka²,

Mittag³

et al. 2011

J Tissue Sci Eng

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Colonic subepithelial myofibroblasts in mucosal inflammation and repair: contribution of bone marrow-derived stem cells to the gut regenerative response

Cited by 75 publications

References 81 publications

MicroRNA‐181a Regulates Local Immune Balance by Inhibiting Proliferation and Immunosuppressive Properties of Mesenchymal Stem Cells

MicroRNA‐181a Regulates Local Immune Balance by Inhibiting Proliferation and Immunosuppressive Properties of Mesenchymal Stem Cells

The Possible Role of Mesenchymal Stem Cells Therapy in the Repair of Experimentally Induced Colitis in Male Albino Rats

The TGF-β1-Induced Expression of Matrix Metalloproteinases in Mesenchymal Stromal Cells is Influenced by Type of Substrate

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