Colonic Secretion of Water and Electrolytes Induced by Bile Acids: Perfusion Studies in Man

Mekjian, H S; Phillips, Sidney F.; Hofmann, Alan F.

doi:10.1172/jci106644

Cited by 547 publications

(250 citation statements)

References 28 publications

Supporting

Mentioning

237

Contrasting

Unclassified

Order By: Relevance

“…A third area not discussed is the role of bile acids in colonic secretion ( 447,448 ) and absorption ( 449 ), as well as recent work suggesting that bile acid activation of TGR5 is essential for normal defecation, at least in the mouse ( 70 ). Details of the biochemical mechanism(s) for bile acid-induced intestinal secretion are being elucidated by several laboratories, among these being that of Stephen Keely in Dublin ( 448 ), and that of Mrinalini Rao in Chicago ( 450 ).…”

Section: Topical Dissolution With Organic Solventsmentioning

confidence: 99%

Key discoveries in bile acid chemistry and biology and their clinical applications: history of the last eight decades

Hofmann

Hagey

2014

Journal of Lipid Research

Self Cite

284

View full text Add to dashboard Cite

conceptions are rare, and provocative judgments stand the test of time. Let us also hope that this effort will be both useful and entertaining. Each of the topics discussed merits at least a full length article, so there will be, of necessity in many instances, consideration of only what we perceive to be the highlights. THE EBB AND FLOW OF MEDICAL INTEREST IN BILE ACIDSAfter the elucidation of the true chemical structure of bile acids in 1932 (see below), there was little interest in bile acids in the Western world. One exception to this statement was the laboratory of Siegfried Thannhauser, who wrote the fi rst textbook of metabolic biochemistry in Germany. He studied cholesterol and bile acid balance in the biliary fi stula dog ( 1 ). During this time, bile acids were sold as liver tonics and laxatives, but there were no placebo-controlled studies showing effi cacy. Indeed, bile acids were considered by the medical profession to have no useful therapeutic properties. The tri-oxo derivative of cholic acid (called "dehydrocholic acid") was known to induce bile fl ow in animals ( 2 ), and was occasionally used to stimulate bile fl ow in patients; but again there were no controlled studies showing effi cacy in hepatobiliary disease.

show abstract

Section: Topical Dissolution With Organic Solventsmentioning

confidence: 99%

Key discoveries in bile acid chemistry and biology and their clinical applications: history of the last eight decades

Hofmann

Hagey

2014

Journal of Lipid Research

Self Cite

284

View full text Add to dashboard Cite

show abstract

“…It is well known that BAs elicit fluid secretion and also increased permeability in the gastrointestinal tract [97][98][99][100][101] . BAs also affect intestinal motility, although this field of study has received relatively little attention [1,102] .…”

Section: Effect Of Ba On Ion Transportmentioning

confidence: 99%

“…Dihydroxy BAs, and in particular DCA and CDCA, exhibit prosecretory/antiabsorptive and mucosal damaging effects in the colon, particularly in their unconjugated forms [100,101] . Conversely, other important BAs such as CA and UDCA are generally considered to have no significant bioactivity at this regard.…”

Section: Effect Of Ba On Ion Transportmentioning

confidence: 99%

Intestinal bile acid physiology and pathophysiology

Martínez‐Augustin¹,

Medina²

2008

WJG

134

114

View full text Add to dashboard Cite

Bile acids (BAs) have a long established role in fat digestion in the intestine by acting as tensioactives, due to their amphipathic characteristics. BAs are reabsorbed very efficiently by the intestinal epithelium and recycled back to the liver via transport mechanisms that have been largely elucidated. The transport and synthesis of BAs are tightly regulated in part by specific plasma membrane receptors and nuclear receptors. In addition to their primary effect, BAs have been claimed to play a role in gastrointestinal cancer, intestinal inflammation and intestinal ionic transport. BAs are not equivalent in any of these biological activities, and structural requirements have been generally identified. In particular, some BAs may be useful for cancer chemoprevention and perhaps in inflammatory bowel disease, although further research is necessary in this field. This review covers the most recent developments in these aspects of BA intestinal biology.

show abstract

“…Bile acids which are not absorbed in the terminal ileum spill over into the proximal colon, where they are deconjugated and dehydroxylated by colonic microbiota to produce secondary bile acids such as deoxycholic acid, which induce colonic secretion. 56 There is also considerable evidence that bile acids can modify colonic motility through direct effects on colonic neuromuscular activity independently of secre-tory effects. 57 Recently, a study showed that measurements of individual urinary bile acids were associated with stool characteristics in patients with IBS; these effects were independent of the effects of colonic transit.…”

Section: Bile Acid Modulators (Chenodeoxycholic Acid and Elobixibat)mentioning

confidence: 99%

Emerging Pharmacologic Therapies for Constipation-predominant Irritable Bowel Syndrome and Chronic Constipation

Eswaran¹,

Guentner²,

Chey³

2014

J Neurogastroenterol Motil

View full text Add to dashboard Cite

Irritable bowel syndrome with constipation and chronic functional constipation are common digestive disorders that negatively impact quality of life and account for billions of dollars in health care costs. Related to the heterogeneity of pathogenesis that underlie these disorders and the failure of symptoms to reliably predict underlying pathophysiology, traditional therapies provide relief to only a subset of affected individuals. The evidence surrounding new and emerging pharmacologic treatments, which include both luminally and systemically acting drugs, is discussed here. These include agents such as lubiprostone, bile acid modulations, guanylate cyclase-C receptor agonists, serotonin receptor modulators and herbal therapies.

show abstract

Colonic Secretion of Water and Electrolytes Induced by Bile Acids: Perfusion Studies in Man

Cited by 547 publications

References 28 publications

Key discoveries in bile acid chemistry and biology and their clinical applications: history of the last eight decades

Key discoveries in bile acid chemistry and biology and their clinical applications: history of the last eight decades

Intestinal bile acid physiology and pathophysiology

Emerging Pharmacologic Therapies for Constipation-predominant Irritable Bowel Syndrome and Chronic Constipation

Contact Info

Product

Resources

About