Colonic mucosal proliferation is related to serum deoxycholic acid levels

Ochsenkühn, Thomas; Bayerdörffer, Ekkehard; Meining, Alexander; Schinkel, Matthias; Thiede, Christian; Nüssler, Volkmar; Sackmann, Michael; Hatz, Rudolf; Neubauer, Andreas; Paumgartner, Gustav

doi:10.1002/(sici)1097-0142(19990415)85:8<1664::aid-cncr4>3.3.co;2-f

Cited by 44 publications

(47 citation statements)

References 2 publications

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“…16 Many reports suggest that elevated concentrations of fecal bile acids are associated with the promotion of colon cancer. [17][18][19] In these reports, Hirano et al 9 demonstrated that AP-1 is associated with the promotion of colon cancer induced by bile acids. Interestingly, however, other transcription factors such as NF-kappa B, Sp1 or ATF/CREB was not affected by bile acid.…”

Section: Discussionmentioning

confidence: 98%

Dominant-negative mutant of c-Jun gene transfer: a novel therapeutic strategy for colorectal cancer

et al. 2004

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Section: Discussionmentioning

confidence: 98%

Dominant-negative mutant of c-Jun gene transfer: a novel therapeutic strategy for colorectal cancer

et al. 2004

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“…A later study by this group suggested that serum DCA concentrations were correlated with the rates of colorectal mucosal proliferation (Ochsenkuhn et al, 1999). However, the high serum DCA concentrations in these studies might be related to the disease process or to dietary modifications made by the patients following their diagnosis.…”

Section: Bile Acids and Colorectal Cancer Riskmentioning

confidence: 89%

A prospective study of serum bile acid concentrations and colorectal cancer risk in post-menopausal women on the island of Guernsey

et al. 2002

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Secondary bile acids produced by the action of the colonic microflora may increase risk of colorectal cancer. Serum bile acid concentrations reflect the faecal bile acid profile and may be of value as biomarkers of risk of colorectal cancer. In a pilot investigation we examined: (i) the reproducibility of measurements of serum bile acids in two blood samples collected several years apart; and (ii) the hypothesis that relatively high levels of secondary bile acids, particularly deoxycholic acid, would be positively associated with an increased risk of colorectal cancer in a prospective study of 3680 women in Guernsey. There was poor reproducibility between repeat measurements of absolute serum concentrations of bile acids, but there was moderately good reproducibility for the ratios of serum concentrations of deoxycholic/cholic acid, lithocholic/chenodeoxycholic and secondary/primary bile acid concentrations (duplicate blood samples were available for 30 women). There were no significant differences in ratios of serum secondary to primary bile acids or in absolute concentrations of bile acids between the 46 women who developed colorectal cancer and their matched controls, although there was a suggestion that an increased risk was associated with a high ratio of deoxycholic/cholic acid (relative risk in top third compared to lower third=3.92 (95% CI 0.91-17.0, P for trend=0.096). These findings suggest that the ratios of serum bile acid concentrations are sufficiently reproducible for epidemiological studies, but that a larger study than our own is needed to adequately test the hypothesis of their relation to cancer risk.

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“…β-glucuronidase activity, which is involved in bile acid metabolism, has been shown to be increased in CRC patients [93]. Colonic mucosal proliferation has been associated positively with secondary bile acid levels [94]. In vitro studies have demonstrated the ability of secondary bile acids to up regulate NF-κβ expression and induce DNA damage through the generation of reactive oxygen species [95].…”

Section: Evidence For Correlations Of Microbiota With Crcmentioning

confidence: 99%

Evidence for Contributions of Gut Microbiota to Colorectal Carcinogenesis

Culpepper¹,

Mai

2012

Curr Nutr Rep

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The contributions of the commensal gut microbiota to the maintenance of human health have long been contemplated. Whereas earlier studies were limited by an inability to analyze microbiota in sufficient depth, recent advances in the application of high throughput sequencing have allowed for an in-depth microbiota analysis in large numbers of individuals. Multiple lines of evidence have been generated that are supportive of an active role of gut microbiota in colorectal carcinogenesis. Although no single microbe has yet been shown to be causally linked to CRC, contributions of the gut microbiota to colorectal carcinogenesis are evident. Further advances in the field, which should include prospective studies in high-risk cohorts, should generate the data needed to start translating findings into microbiota-based screening and prevention regimen that can help to reduce the burden of CRC.

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Colonic mucosal proliferation is related to serum deoxycholic acid levels

Cited by 44 publications

References 2 publications

Dominant-negative mutant of c-Jun gene transfer: a novel therapeutic strategy for colorectal cancer

Dominant-negative mutant of c-Jun gene transfer: a novel therapeutic strategy for colorectal cancer

A prospective study of serum bile acid concentrations and colorectal cancer risk in post-menopausal women on the island of Guernsey

Evidence for Contributions of Gut Microbiota to Colorectal Carcinogenesis

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