Colonic migrating and nonmigrating motor complexes in dogs

Abstract

We report here the characteristics of a cyclic motor activity in the colon of conscious dogs and its relationship to small intestinal migrating motor complexes (MMCs). The colonic motor activity was recorded by four equispaced strain gauges and small intestinal myoelectric activity by four equispaced bipolar electrodes. The colonic motor activity was characterized by rhythmic bursts of contractions. The mean durations of bursts of contractions varied from 7.0 to 11.5 min at the four colonic recording sites. Those bursts of contractions which migrated over at least three recording sites were called colonic migrating motor complexes (CMMCs). All other patterns of bursts of contractions were called colonic nonmigrating motor complexes (CNMCs). A total of 160 CMMCs were recorded during a total recording period of 132 h; 151 CMMCs migrated caudad and 9 orad. The mean period of caudad migrating CMMCs was 53.3 +/- 5.4 (SE) min, and their mean migration time was 11.3 +/- 1.2 (SE) min. The onset of CMMCs was not temporally related to the onset of small intestinal migrating myoelectric complexes in the duodenum or their arrival in the terminal ileum. CMMCs did not have phases I to IV like those of small intestinal MMCs, but two consecutive CMMCs were separated by a quiescent state or by one or more randomly occurring bursts of contractions (CNMCs).

Stimulatory Action of Itopride Hydrochloride on Colonic Motor Activity in Vitro and in Vivo

“…3C and 4C). In addition, itopride produced giant migrating contractions, which were high-amplitude, rapidly migrating contractions that propelled colonic contents to the rectum (Sarna et al, 1984;Karaus and Sarna, 1987), followed by defecation in some dogs at 10 mg/kg, but this was not seen with cisapride nor mosapride. Throughout this experiment, no behavioral changes were observed.…”

Effect of Traditional Acupuncture on Proximal Colonic Motility in Conscious Dogs

“…Data analysis: The method used to quantify the proximal colonic motility has previously been described by Sarna et al [21][22][23]. Proximal colonic myoelectrical activity consisted of alternating periods of quiescent and contractile states ( Fig.…”

“…A contractile state consisted of a burst of contractions that lasted for at least 1 min. Two contractile states were considered different in there was a quiescent period of at least 2 min between them [21,23]. The contractile states were quantified by determining the total duration/ hr, mean duration, cycle length and the frequency/hr [22].…”

Intragastric Dai-Kenchu-To, a Japanese Herbal Medicine, Stimulates Colonic Motility via Transient Receptor Potential Cation Channel Subfamily V Member 1 in Dogs

“…One was the colonic motor complex (CMC) consisting of tonic contractions superimposed of phasic contractions, most of which migrated distally with speeds as slow as 4 cm/min (Sarna et al 1984;Shibata et al 1993). The other type of contractions was the giant migrating contraction (GMC) which had a very high amplitude and velocity as fast as 60 cm/min.…”