Colonic Microbiota and Chronic Kidney Disease. Message One

Abstract

Interest in studying the role of the gastrointestinal tract in maintaining homeostasis in chronic kidney disease is a traditional one. It served, in particular, as a starting point for the creation of enterosorbents. However, if earlier the main attention was paid to the mechanical removal of a number of potentially dangerous biologically active substances, recently an intestinal microbiota has become an object of interest. The first part of the literature review on this topic is devoted to questions of terminology, the normal physiology of the colon microbiota. A detailed description of dysbiosis is given. The features of the main groups of microorganisms are reflected. The hypothetical and confirmed interrelations of the intestine-kidney axis are presented. The pathogenetic mechanisms of the colon dysbiosis influence on the processes of local and systemic inflammation are discussed. The influence of dysbiosis on the state of the kidney parenchyma and its participation in the progression of CKD are debated.

Chronic kidney disease and comorbid diseases of gastrointestinal tract

“…Последствия изменения кишечной микробиоты. на фоне чего происходит поддержание системной воспалительной реакции, большее повреждение эндотелия и поражение сердечно-сосудистой системы [14]. Увеличивается число бактерий семейств Enterobacteriaceae (Enterobacter, Klebsiella, Escherichia), Enterococсaceae и вида Clostridium perfringens при этом уменьшается содержание бактерий семейств Bifi dobacteriaceae, Lactobacillaceae, Bacteroidaceae, Prevotellaceae.…”

“…Увеличивается число бактерий семейств Enterobacteriaceae (Enterobacter, Klebsiella, Escherichia), Enterococсaceae и вида Clostridium perfringens при этом уменьшается содержание бактерий семейств Bifi dobacteriaceae, Lactobacillaceae, Bacteroidaceae, Prevotellaceae. Наблюдается значительное снижение субпопуляций Roseburia и Faecalibacterium prausnitzii (бутиратпродуцирующие виды) [14,29,36,46].…”