Colonic manometry via appendicostomy shows reduced frequency, amplitude, and length of propagating sequences in children with slow-transit constipation

Stanton, Michael; Hutson, John M.; Simpson, Dianne; Oliver, Mark; Dinning, Phil G.; Cook, Ian J.; Catto‐Smith, Anthony G.

doi:10.1016/j.jpedsurg.2005.03.047

Cited by 28 publications

(10 citation statements)

References 38 publications

(58 reference statements)

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“…Colonic activity has been measured using multilumen catheters to measure pressure changes in the colon. Twenty‐four hour studies in STC children show they have less high amplitude propagating contractions (HAPC) and have a reduced frequency of antegrade propagating contractions and show a poor waking and postmeal responses 90,91 . Bisacodyl challenge also produces less HAPC in adults with STC 92…”

Section: Discussionmentioning

confidence: 99%

Substance P and vasoactive intestinal peptide are reduced in right transverse colon in pediatric slow‐transit constipation

King

Sutcliffe

Ong

et al. 2010

Neurogastroenterology Motil

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Section: Discussionmentioning

confidence: 99%

Substance P and vasoactive intestinal peptide are reduced in right transverse colon in pediatric slow‐transit constipation

King

Sutcliffe

Ong

et al. 2010

Neurogastroenterology Motil

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“…ISTC has recently been proposed as a potentially treatable cause of constipation in a percentage of constipated children [1,2]. With a view to seeing, and perhaps treating any of these children in our clinic we began offering nuclear transit studies to children with intractable constipation 18 months ago.…”

Section: Introductionmentioning

confidence: 99%

Idiopathic slow transit constipation is rare

Croaker

Pearce

et al. 2007

Pediatr Surg Int

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We hypothesise that constipated children would be more likely to come from a socially deprived background. We also hypothesise that a percentage of children with resistant constipation would have a congenital gut motility problem that might be recognised at birth, and that some of these would have slow transit constipation that could be recognised on nuclear transit study. One hundred and forty children with a constipation related diagnosis were seen in the last 4 years, and were reviewed as a retrospective audit. Twenty-six children who were felt likely to have a congenital cause for their constipation were offered nuclear colon transit study to search for slow transit constipation. One hundred and forty children from the constipation clinic were reviewed. There were 67 females (47.9%) and 73 males (52.1%), a sex ratio near equality. The mean age at presentation was 5.38 years. Forty-one percent were formally discharged, 36% were lost to follow up, and 23% are still being seen. There was a highly significant tendency for these children to have delayed passage of meconium, as compared normal newborns (P << 0.001). Twenty-six children were considered for possible transit study, and 14 were performed. Four of these were normal, seven showed hold up in the recto-sigmoid, and three showed more proximal slow transit. Two of these probably have non ISTC diagnoses. Social class seems similar to the general population on the criterion employed. Delayed passage of meconium in this group was significantly more frequent than in the general population, but only one of the group seems likely to have truly idiopathic slow transit constipation, and he did not have delayed passage of meconium. There is no evidence for an effect of social class in this population. Idiopathic slow transit constipation itself is rare.

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“…Consequently, 0022 Constipation may be due to a holdup either at the level of the anorectum (functional fecal retention) or in the more proximal colon (slow-transit constipation [STC]). Slowtransit constipation has become an established diagnosis in the 9 years after its radiological description by Benninga et al [5], and clinical, radiological, and manometric parameters of pediatric STC have now been described [6][7][8][9][10].…”

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confidence: 99%

The antegrade continence enema successfully treats idiopathic slow-transit constipation

King

Sutcliffe

Southwell

et al. 2005

Journal of Pediatric Surgery

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Colonic manometry via appendicostomy shows reduced frequency, amplitude, and length of propagating sequences in children with slow-transit constipation

Cited by 28 publications

References 38 publications

Substance P and vasoactive intestinal peptide are reduced in right transverse colon in pediatric slow‐transit constipation

Substance P and vasoactive intestinal peptide are reduced in right transverse colon in pediatric slow‐transit constipation

Idiopathic slow transit constipation is rare

The antegrade continence enema successfully treats idiopathic slow-transit constipation

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