Colonic manometry in children with slow transit constipation shows reduced frequency, amplitude and length of propagating sequences

Neurogastroenterology Motil

Sutcliffe

Ong

et al. 2010

Section: Methodsmentioning

confidence: 99%

Substance P and vasoactive intestinal peptide are reduced in right transverse colon in pediatric slow‐transit constipation

Neurogastroenterology Motil

Sutcliffe

Ong

et al. 2010

“…The child diagnosed with anal defects (anorectal anomaly with postoperative incontinence) had normal levels of colonic activity (compared to healthy adults, mean age 25 years) 47 , showing that colonic propulsion is normal adjacent to anal defects. Conversely, all five STC children had low frequency and amplitude of propagating sequences (especially HAPC), an increase in retrograde propagating sequences and lacked the increase in amplitude of propagating sequences normally induced by meals and waking 62 (Fig. 4).…”

Section: Colonic Manometry: a Technique To Separate Colonic Dysmotilimentioning

confidence: 98%

Chronic constipation in children: Organic disorders are a major cause

Southwell

J Paediatrics Child Health

Hutson

2005

Diagnostic tools for paediatric chronic constipation have been limited, leading to over 90% of patients with treatment-resistant constipation being diagnosed with chronic idiopathic constipation, with no discernible organic cause. Work in our institution suggests that a number of children with intractable symptoms actually have slow colonic transit leading to slow transit constipation. This paper reviews recent data suggesting that a significant number of the children with chronic treatment-resistant constipation may have organic causes (slow colonic transit and outlet obstruction) and suggests new approaches to the management of children with chronic treatment-resistant constipation.

“…With this technique, five children with STC, confirmed by scintigraphy, have recently undergone colonic manometry 28 . When compared to healthy young adults 21 all five children exhibited:…”

Section: Slow Transit Constipationmentioning

confidence: 99%

Paediatric constipation for adult surgeons − article 1: targeting the cause

Sutcliffe

Southwell

et al. 2004

ANZ Journal of Surgery

Self Cite

Constipation is very common in all age groups and can be resistant to standard therapies, producing chronic morbidity. Childhood onset constipation frequently produces symptoms that persist into adulthood. Recent advances have been made in the diagnosis and treatment of childhood constipation that could have application in adult practice. In the first part of the present review, the methods of differentiation of patients with a disorder of colonic motility from those with an anorectal hold-up are discussed. Slow transit constipation, with distinct features on colonic manometry and scintigraphy, has only recently been recognized in children. This diagnosis, together with a novel method of placement of a manometric catheter, is described. While the cause of slow transit constipation remains unclear, clinical features that differ between children and adults may provide an insight into the aetiology. The diagnosis of intestinal neuronal dysplasia is explained and the controversy surrounding the diagnosis outlined. We propose that the traditional histological criteria exclude many other clinically significant forms of dysplasia of the enteric nervous system and should be extended.