Colonic malacoplakia and abdominal tuberculosis in a child

Satti, Mohamed B.; Abu-Melha, Abdullah; Taha, Omer M. A.; Al‐Idrissi, Hassan Y.

doi:10.1007/bf02560441

Cited by 12 publications

(1 citation statement)

References 13 publications

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“…Associations between malakoplakia and specific pathogens have been suggested: most commonly Escherichia coli and other gram-negative bacteria [6], but also Mycobacterium tuberculosis [8][9][10], Rhodococcus equi in immunocompromised patients [11], Herpes simplex in malakoplakia of the central nervous system [12], and several other pathogens [6]. An association between malakoplakia of the colon and colorectal adenocarcinoma has also been suggested [13][14][15][16].…”

Section: Discussionmentioning

confidence: 99%

Presacral malakoplakia presenting as foot drop: a case report

et al. 2023

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Background Malakoplakia is a rare condition characterized by inflammatory masses with specific histological characteristics. These soft tissue masses can mimic tumors and tend to develop in association with chronic or recurrent infections, typically of the urinary tract. A specific defect in innate immunity has been described. In the absence of randomized controlled trials, management is based on an understanding of the biology and on case reports. Case presentation Here we describe a case of presacral malakoplakia in a British Indian woman in her late 30s, presenting with complex unilateral foot drop. Four years earlier, she had suffered a protracted episode of intrapelvic sepsis following a caesarean delivery. Resection of her presacral soft tissue mass was not possible. She received empiric antibiotics, a cholinergic agonist, and ascorbic acid. She responded well to medical management both when first treated and following a recurrence of symptoms after completing an initial 8 months of therapy. Whole exome sequencing of the patient and her parents was undertaken but no clear causal variant was identified. Conclusions Malakoplakia is uncommon but the diagnosis should be considered where soft tissue masses develop at the site of chronic or recurrent infections. Obtaining tissue for histological examination is key to making the diagnosis. This case suggests that surgical resection is not always needed to achieve a good clinical and radiological outcome.

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Section: Discussionmentioning

confidence: 99%

Presacral malakoplakia presenting as foot drop: a case report

et al. 2023

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Malacoplakia. Two case reports and a comparison of treatment modalities based on a literature review

Voort

Velden²,

Wassenaar³

et al. 1996

Archives of Internal Medicine

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Malacoplakia is a rare infectious disease that has been almost exclusi vely reported in urology and pathology journals. We studied two cases of malacoplakia that were primarily referred to the department of internal medicine because of fever and abdominal masses. In one patient, malacoplakia was diagnosed in the unusual ovarian location, while in the other patient a large renal mass was found and ciprofloxacin therapy failed because of bacterial resistance. The clinical and radiologic appearance of malacoplakia often mimics that of a malignant tumor. The principal disorder is probably a monocytic-macrophagic bactericidal defect. A definitive diagnosis depends on microscopic detection of Michaelis-Gutmann bodies by means of von Kossa stain. We outlined treatment strategies on the basis of a review of the literature since 1981, which included 140 cases. If possible, immunosuppressive drugs should be stopped. Quinolone antibiotic treatment and surgical excision or incision and drainage lead to the highest cure rates (90% and 81%, respectively). Specific intracellular penetration of quinolone antibiotics is a possible reason for the higher cure rate achieved with these antibiotics. Bethanechol has been suggested to correct the supposed fundamental disturbance by increasing the intrecellular cyclic guanosine monophosphate concentration, but there is still no convincing evidence of its clinical efficacy.

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Malacoplakia

Stein¹

2003

Anorectal and Colon Diseases

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Colonic malacoplakia and abdominal tuberculosis in a child

Cited by 12 publications

References 13 publications

Presacral malakoplakia presenting as foot drop: a case report

Presacral malakoplakia presenting as foot drop: a case report

Malacoplakia. Two case reports and a comparison of treatment modalities based on a literature review

Malacoplakia

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