Colonic Infection by Histoplasma capsulatum in a Liver Transplant Patient: A Case Report

Ferreira, Gustavo de Sousa Arantes; Watanabe, André Luís Conde; Trevizoli, Natália de Carvalho; Jorge, Fernando; Camposa, Priscila Brizolla de; Couto, Carolina de Fatima; Lima, Laura Viana de; Raupp, Deborah Roberta Liduario

doi:10.1016/j.transproceed.2020.01.071

Cited by 6 publications

(10 citation statements)

References 23 publications

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“…Analysis of the 123 well-documented cases showed the clinical presentation of GIH was often non-specific and mimicked several other gastrointestinal conditions and pathologies, including abdominal tuberculosis (n = 3, 2.4%) [ 85 , 96 , 102 ], GIH and TB coinfection was reported in four [3.3%] cases [ 78 , 87 , 96 , 98 ], inflammatory bowel disease (n = 9, 7.3%) [ 21 , 33 , 40 , 52 , 69 , 75 , 89 , 105 , 107 ], intestinal obstruction (n = 15, 12.2%) [ 15 , 21 , 39 , 50 , 57 , 64 , 71 , 77 , 81 , 89 , 95 , 102 , 103 , 104 , 117 ], abdominal malignancy (n = 9, 7.3%) [ 14 , 16 , 31 , 80 , 83 , 101 , 102 , 108 , 112 ], GI bleeding (n = 29, 23.6%) [ 17 , 18 , 25 , 26 , 27 , 29 , 30 , 31 , 33 , 37 , 41 , 44 , 53 , 56 ,…”

Section: Resultsmentioning

confidence: 99%

Gastrointestinal Histoplasmosis: A Descriptive Review, 2001–2021

Ekeng

Itam-Eyo

Osaigbovo

et al. 2023

Life

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Gastrointestinal histoplasmosis (GIH) is infrequently described in people without underlying HIV infection. We aimed to compare the clinical presentation of GIH in people with and without HIV infection. We conducted a literature search of published cases of GIH from 2001–2021 and found 212 cases. Of these, 142 (67.0%) were male, and 124 (58.5%) had HIV infection. Most cases were from North America (n = 88, 41.5%) and South America (n = 79, 37.3%). Of the 212 cases, 123 (58.0%) were included in both clinical and pathological analyses. The remainder were excluded as details about clinical and pathological findings were not available. Of the 123 cases, 41 had HIV infection while 82 were without HIV infection. The diagnosis was predominantly by histopathology (n = 109, 88.6%). A significant proportion of people with HIV infection had abdominal pain as the most predominant symptom of GIH compared to those without HIV infection (65.9% versus 41.9%, p < 0.05). The colon was the most affected site with a slightly higher proportion in those with HIV infection compared with cases without HIV infection (46.3% versus 42.7%). The commonest pathologic findings were caecal and ileal ulcers. Caecal ulcers were significantly more frequent in cases with HIV infection compared to those without HIV (32.1% versus 7.1%, p < 0.05). Despite being more common in people with HIV infection, GIH also affects people without HIV infection with similar clinical presentations.

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Section: Resultsmentioning

confidence: 99%

Gastrointestinal Histoplasmosis: A Descriptive Review, 2001–2021

Ekeng

Itam-Eyo

Osaigbovo

et al. 2023

Life

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“…A distinct situation is the case of airborne microorganisms, such as filamentous fungi (Aspergillus, Rhizopus, Mucor, etc.) and other already mentioned environmental pathogens (H. capsulatum, C. neoformans) colonizing the host via the upper respiratory tract [14,16,17].…”

Section: Opportunistic Infections and Coinfectionmentioning

confidence: 99%

“…In HIV-Leishmania coinfected patients, visceral leishmaniosis can accelerate disease, decreasing the likelihood of patient survival [41]. C. neoformans and H. capsulatum are the only agents that have been isolated, particularly from immunocompromised individuals [14,16]. Their participation in coinfection is very rare, but Nunez and colleagues reported simultaneous infections in an HIV-negative 69-year-old man with chronic obstructive pulmonary disease and type II diabetes mellitus [42].…”

Section: Opportunistic Infections and Coinfectionmentioning

confidence: 99%

“…and the environmental pathogens (Cryptococcus neoformans, Cryptococcus gattii, Aspergillus fumigatus, and thermally dimorphic fungi) [11]. Fungi have frequently caused diseases in immunocompromised patients with HIV, cancer, diabetes and patients treated with immunosuppressive drugs [12][13][14][15][16][17]. In a separate category are healthy individuals with flaws in the immune system due to age (children and elderly), antibiotic treatment or pregnancy [18][19][20][21].…”

Section: Introductionmentioning

confidence: 99%

“…In a separate category are healthy individuals with flaws in the immune system due to age (children and elderly), antibiotic treatment or pregnancy [18][19][20][21]. In addition to common diseases, fungi can cause very serious life-threatening infections [14,16,22,23].…”

Section: Introductionmentioning

confidence: 99%

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Opportunist Coinfections by Nontuberculous Mycobacteria and Fungi in Immunocompromised Patients

2020

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Nontuberculous mycobacteria (NTM) and many fungal species (spp.) are commonly associated with opportunistic infections (OPIs) in immunocompromised individuals. Moreover, occurrence of concomitant infection by NTM (mainly spp. of Mycobacterium avium complex and Mycobacterium abscessus complex) and fungal spp. (mainly, Aspergillus fumigatus, Histoplasma capsulatum and Cryptococcus neoformans) is very challenging and is associated with poor patient prognosis. The most frequent clinical symptoms for coinfection and infection by single agents (fungi or NTM) are similar. For this reason, the accurate identification of the aetiological agent(s) is crucial to select the best treatment approach. Despite the significance of this topic it has not been sufficiently addressed in the literature. This review aims at summarizing case reports and studies on NTM and fungi coinfection during the last 20 years. In addition, it briefly characterizes OPIs and coinfection, describes key features of opportunistic pathogens (e.g., NTM and fungi) and human host predisposing conditions to OPIs onset and outcome. The review could interest a wide spectrum of audiences, including medical doctors and scientists, to improve awareness of these infections, leading to early identification in clinical settings and increasing research in the field. Improved diagnosis and availability of therapeutic options might contribute to improve the prognosis of patients’ survival.

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Mycophenolate/prednisone/tacrolimus

2020

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Colonic Infection by Histoplasma capsulatum in a Liver Transplant Patient: A Case Report

Cited by 6 publications

References 23 publications

Gastrointestinal Histoplasmosis: A Descriptive Review, 2001–2021

Gastrointestinal Histoplasmosis: A Descriptive Review, 2001–2021

Opportunist Coinfections by Nontuberculous Mycobacteria and Fungi in Immunocompromised Patients

Mycophenolate/prednisone/tacrolimus

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