Colonic carcinoid tumors: a clinicopathologic study of 23 patients from a single institution

Waisberg, Daniel Reis; Fava, Antonio; Martins, Lourdes Conceição; Matos, Leandro Luongo de; Franco, Maria Isete Fares; Waisberg, Jaques

doi:10.1590/s0004-28032009000400008

Cited by 15 publications

(20 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…This study is one of only a few studies that provide a comprehensive clinicopathologic profile of extraapendiceal colonic carcinoid tumors. 2,3,7 Our specific findings will be further discussed in the context of the known literature to provide a thorough review of the current understanding of the diagnosis, treatment, and prognosis of this rare tumor.…”

Section: Discussionmentioning

confidence: 96%

“…2,3,7 The variations in site-specific incidence and the overall poor prognosis of colonic carcinoids demands further investigation. Therefore, the objective of this study was to better characterize the clinicopathologic profile of extraappendiceal colonic carcinoid tumors, and place these findings in the context of a comprehensive literature review of colonic carcinoid.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Clinicopathologic characteristics of colonic carcinoid tumors

Murray

Lloyd

Sippel

et al. 2013

Journal of Surgical Research

View full text Add to dashboard Cite

Background Extraappendiceal colonic carcinoids are uncommon neuroendocrine tumors with a poor prognosis compared to carcinoids of other gastrointestinal origins. Few studies have examined the clinicopathologic profile and behavior of this rare tumor. Materials and Methods A retrospective analysis was performed on patients with colonic carcinoid tumors evaluated at a single tertiary care center between 1996 and 2012. Collected data included patient and tumor characteristics, presentation, treatment, recurrence and survival. Results were integrated into a comprehensive review of the colonic carcinoid literature. Results In total, 114 patients with colorectal carcinoid tumors were identified, and 15 patients with extraappendiceal tumors were analyzed. The mean age was 58.6±3.0 years, and subjects were predominantly male (73.3%). The most common presenting complaint was abdominal pain (33.3%), although 26.7% of patients were asymptomatic. Cecal tumors were the most prevalent (73.3%), and the majority of patients underwent right hemicolectomy. Three patients with lesions <1 cm were treated endoscopically. The mean tumor diameter was 2.9±0.5 cm, with lymph node or distant metastasis present in 53.3% and 26.7%, respectively. All but 2 patients underwent a presumed curative resection. During a mean follow-up of 4.2±1.0 years, there was only one death (non-carcinoid specific). Eleven patients were alive without evidence of disease at last follow-up, and 3 patients were alive with disease, one of which initially had a presumed curative resection but recurred. Conclusions This case series further elucidates the clinicopathologic characteristics of colonic carcinoid tumors, which aids physicians in guiding the diagnosis and management of these rare tumors.

show abstract

Section: Discussionmentioning

confidence: 96%

Section: Introductionmentioning

confidence: 99%

Clinicopathologic characteristics of colonic carcinoid tumors

Murray

Lloyd

Sippel

et al. 2013

Journal of Surgical Research

View full text Add to dashboard Cite

show abstract

“…Las lesiones se localizan sobre todo en el colon derecho y con frecuencia cuando se detectan ya son de gran tamaño (> 2 cm). Los tumores carcinoides de colon tienen la particular característica de poder asociarse a otros tumores carcinoides de forma sincrónica y también a otros tumores no carcinoides (13%) 4 . El tamaño del tumor y la invasión vascular son los factores pronósticos más importantes en el carcinoma neuroendocrino gastrointestinal.…”

Section: Discussionunclassified

“…La resección endoscópica podría ser curativa en el caso de lesiones pequeñas (< 1 cm) y con criterios histológicos de buen pronóstico 3,4 . El tratamiento de elección de la lesión primaria en los tumores neuroendocrinos es la cirugía, aun en presencia de metástasis hepáticas.…”

Section: Discussionunclassified

Carcinoma neuroendocrino de colon poco diferenciado con metástasis hepáticas

Chahri

Vega

Muñoz

et al. 2012

Gastroenterología y Hepatología

View full text Add to dashboard Cite

“…Within the gastrointestinal tract, carcinoid tumors are most commonly found in the appendix followed by the ileum, rectum, and stomach (3,14,15,21,22,24) . Carcinoid tumors represent 1/3 of all malignant tumors that affect the small intestine (15,18) .…”

mentioning

confidence: 99%

Carcinoid Tumor of the Duodenum:

Waisberg

Joppert-Netto

Vasconcellos

et al. 2013

Arq. Gastroenterol.

Self Cite

View full text Add to dashboard Cite

ContextDuodenal carcinoids are extremely rare, and their characteristics and biological behavior have not been fully elucidated.ObjectiveTo analyze the clinicopathological characteristics of patients with resected duodenal carcinoids.MethodsTwenty patients (12 females and 8 males) were investigated. Their average age was 66.4 ± 5.8 years old (43 to 88 years old). The data corresponding to the clinical picture, diagnosis, treatment, and prognosis of patients with duodenal carcinoid tumors subjected to resection over a period of 18 years (1993-2011) were analyzed.ResultsThe most common symptoms were dyspepsia (50%) and epigastric pain (45%) followed by weight loss (10%) and vomiting (5%). Carcinoid syndrome was not observed in any patient. The lesion was located on the first part of the duodenum in 15 (75%) patients, the second part in 4 (20%) patients, and the third part in 1 (5%) patient. The diagnosis of a carcinoid tumor was established through an endoscopic excision biopsy in 19 (95%) patients and an histopathological examination of the surgical specimen in 1 (5%) patient. The average tumor size was 1.1 cm ± 0.4 cm (0.3 cm to 6.0 cm). Nineteen (95%) patients were initially treated by endoscopic resection of the duodenal lesion. One patient (5%), whose tumor was on the third part of the duodenum underwent a duodenectomy of the third and fourth duodenal parts and duodenojejunal anastomosis. The duodenal carcinoid resection margin was involved in four (20%) patients. Four (20%) patients were subjected to a partial gastrectomy to fully remove the lesion. The tumor was restricted to the submucosal layer in 16 (80%) cases, and it penetrated into the muscular layer in 4 (20%) cases. All patients exhibited positive chromogranin A, neuron-specific enolase, and/or synaptophysin immunostaining. The average duration of the follow-up period was 39.6 months (3 to 96 months). Twelve (60%) of the 20 cases in this series are alive without any evidence of active disease. Only one (5%) patient died due to liver metastases of the duodenal carcinoid.ConclusionsDuodenal carcinoids are rare and indolent tumors usually associated with a benign progression. Duodenoscopy, computerized tomography, and endoscopic ultrasound should be performed to evaluate the tumor size, the level of wall invasion, and the presence of regional or distant lymphatic metastases. Endoscopic removal of tumors smaller than 1.0 cm without periampullary localization or evidence of muscular propria layer invasion assessed by histology and/or endoscopic ultrasound is recommended. The endoscopic resection with a carcinoid tumor size between 1.0 cm and 2.0 cm can be incomplete and require new endoscopic resection or even surgical removal. Duodenal carcinoid larger than 2.0 cm require full-thickness resection and concomitant lymphadenectomy.

show abstract

Colonic carcinoid tumors: a clinicopathologic study of 23 patients from a single institution

Cited by 15 publications

References 22 publications

Clinicopathologic characteristics of colonic carcinoid tumors

Clinicopathologic characteristics of colonic carcinoid tumors

Carcinoma neuroendocrino de colon poco diferenciado con metástasis hepáticas

Carcinoid Tumor of the Duodenum:

Contact Info

Product

Resources

About