Colonic adenocarcinoma, mucosa associated lymphoid tissue lymphoma and tuberculosis in a segment of colon: A case report

Velu, Ambedkar Raj Kulandai; Srinivasamurthy, Banushree C; Nagarajan, Krishnan; Sinduja, Ilavarasi

doi:10.4251/wjgo.v6.i9.377

Cited by 7 publications

(8 citation statements)

References 7 publications

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“…To our knowledge, there are fifteen cases of this type of collision to date, including this report (Table 1) [9][10][11][12][13][14][15][16][17][18][19][20][21][22]. There is a male and elderly predominance at an average age The majority of collisions arise in the cecum or rectum, with eight arising from the right colon, one from the transverse colon, and six from the left colon.…”

Section: Discussionmentioning

confidence: 97%

Collision tumor of colonic adenocarcinoma and EBV-driven large B-cell lymphoma: A case report and review of literature

Huang

Hou

et al. 2015

Cancer Treatment Communications

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Introduction: Collision tumors of adenocarcinoma and lymphoma in the gastrointestinal tract are especially rare with few reported cases in literature. We report a unique case of a collision tumor and perform a literature review.Presentation of case: An 86-year-old patient with a history of rheumatoid arthritis on chronic azathioprine and prednisone was found to have an invasive adenocarcinoma in the descending colon. A large atypical lymphocytic infiltrate was found at the base of this lesion, which demonstrated CD20, lambda and EBER positivity consistent with adenocarcinoma colliding with EBV-driven and lambdarestricted large B-cell lymphoma.Discussion: With this report, there are now fifteen cases of this type of collision tumor although the true incidence may be higher. Our case is unique among previous reports as the collision developed within the setting of iatrogenic immunosuppression and tumor EBV positivity was demonstrated. The pathogenesis is unknown, and diagnosis requires a high-degree of suspicion.

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Section: Discussionmentioning

confidence: 97%

Collision tumor of colonic adenocarcinoma and EBV-driven large B-cell lymphoma: A case report and review of literature

Huang

Hou

et al. 2015

Cancer Treatment Communications

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“…Colonic MALT lymphoma was found to be a metachronous malignancy in a patient who had undergone hemicolectomy for a prior colon adenocarcinoma[ 32 ]. Very few cases have been reported on synchronous colonic MALT lymphoma and adenocarcinoma simultaneously present in the same patient[ 5 - 7 ]. Synchronous adenocarcinoma and MALT lymphomas may exist in the same tumor[ 5 - 7 ], which is also called a collision tumor.…”

Section: Discussionmentioning

confidence: 99%

“…Very few cases have been reported on synchronous colonic MALT lymphoma and adenocarcinoma simultaneously present in the same patient[ 5 - 7 ]. Synchronous adenocarcinoma and MALT lymphomas may exist in the same tumor[ 5 - 7 ], which is also called a collision tumor. Some synchronous colonic adenocarcinomas are accompanied by MALT lymphoma in the lymph nodes and omentum[ 6 ].…”

Section: Discussionmentioning

confidence: 99%

“…In our case, the MALT lymphoma found on surveillance colonoscopy five months after surgery and chemotherapy for sigmoid adenocarcinoma occurred neither at the same time nor in the same segment of the colon. Immune-mediated diseases, such as Hashimoto's thyroiditis, Sjögren's syndrome, and inflammatory bowel disease, might be risk factors for colonic MALT lymphoma[ 15 , 33 , 34 ], as well as immunodeficiency factors, such as HIV, steroid use, and tuberculosis[ 5 , 35 ]. Therefore, colonic MALT lymphoma found after surgery and chemotherapy for adenocarcinoma may result from immunosuppression.…”

Section: Discussionmentioning

confidence: 99%

“…MALT lymphoma occurring in the GI tract is found mainly in the stomach, accounting for more than half of all cases, followed by MALT lymphomas in the small intestine, cecum, and colorectum[ 4 ]. The synchronous occurrence of colonic MALT lymphoma and adenocarcinoma in the same patient is extremely rare[ 5 - 7 ]. Only one case of synchronous colonic MALT lymphoma diagnosed after hemicolectomy due to adenocarcinoma within six months has been reported in the literature to date[ 8 ].…”

Section: Introductionmentioning

confidence: 99%

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Synchronous colonic mucosa-associated lymphoid tissue lymphoma found after surgery for adenocarcinoma: A case report and review of literature

Chen

Dong

et al. 2020

WJCC

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BACKGROUND Mucosa-associated lymphoid tissue (MALT) lymphoma is a subtype of non-Hodgkin lymphoma that is mainly involved in the gastrointestinal tract. The synchronous occurrence of colonic MALT lymphoma and adenocarcinoma in the same patient is extremely rare. We here report a case of synchronous colonic MALT lymphoma found on surveillance colonoscopy five months after surgery and chemotherapy for sigmoid adenocarcinoma. CASE SUMMARY A 67-year-old man was admitted because of hematochezia for two months. Colonoscopy suggested a colonic tumor before hospitalization. Abdominal computed tomography (CT) revealed local thickening of the sigmoid colon. The patient underwent a left hemicolectomy with local lymph node dissection. The histopathology revealed moderately differentiated adenocarcinoma and partially mucinous adenocarcinoma. The pTNM stage was T3N1Mx. The patient received chemotherapy with six cycles of mFOLFOX6 after surgery. Colonoscopy was performed five months later and revealed single, flat, polypoid lesions of the colon 33 cm away from the anus. Subsequently, the patient underwent endoscopic mucosal resection for further diagnosis. The pathological diagnosis was MALT lymphoma. Positron emission tomography /CT suggested metastasis. The patient refused further treatment and died ten months later. CONCLUSION Colonic MALT lymphoma may occur after surgery and chemotherapy for adenocarcinoma as a synchronous malignancy. Regular surveillance colonoscopy and careful monitoring after surgery are critical.

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Synchronous or collision solid neoplasms and lymphomas: A systematic review of 308 case reports

et al. 2022

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Background: The presence of a lymphoma associated with a solid synchronous neoplasm or collision neoplasm has been rarely in the literature, and a detailed characterization of these cases is lacking to date.Objective: To describe the main clinicopathological features of synchronous/collision tumors.Methods: A systematic search in PubMed, Scielo, and Virtual Health Library literature databases for cases or case series of synchronous or collision lymphoma and other solid neoplasms reported up to March 2021 was performed. Three reviewers independently screened the literature, extracted data, and assessed the quality of the included studies. The systematic review was performed following the Preferred Reporting Items for Systematic Meta-Analyses guidelines.Results: Mean age of patients was 62.9 years (52.9% men). A total of 308 cases were included (62% synchronous and 38% collision). The most frequent location of both synchronous and collision tumors was the gastrointestinal tract with the most common solid neoplasm being adenocarcinoma, and the most frequent lymphoma diffuse large B-cell lymphoma (21.7%) and mucosa-associated lymphoid tissue lymphoma (20.4%). Of the total number of mucosa-associated lymphoid tissue lymphomas and gastric adenocarcinomas, the presence of Helicobacter pylori infection was documented in 47.3% of them. Only 2% of all cases had a previous history of lymphoma. Thus, in most cases (98%), lymphoma was discovery incidentally. In addition, nodal lymphoma was associated with metastasis in 29 (9.4%) cases as collision tumor, most commonly (90%) in locoregional lymph nodes of the solid neoplasm. Conclusions:The frequent association of some type of B-cell lymphoma and adenocarcinoma in synchronous/collision tumors of the gastrointestinal tract points to common pathogenic mechanisms in both neoplasia, particularly related to chronic inflammation in this location. In most cases, lymphoma identified in locoregional lymph nodes or distant of a carcinoma seems to represent an incidental finding during the carcinoma diagnostic/therapeutic approach. A synergy between carcinoma and lymphoma (involving inflammation and immunosuppression mechanisms) may favor tumor progression and dissemination. A better understating of the interactions lymphoma/carcinoma in the setting of synchronous/collision tumors may help to improve patient management and prognosis.

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Colonic adenocarcinoma, mucosa associated lymphoid tissue lymphoma and tuberculosis in a segment of colon: A case report

Cited by 7 publications

References 7 publications

Collision tumor of colonic adenocarcinoma and EBV-driven large B-cell lymphoma: A case report and review of literature

Collision tumor of colonic adenocarcinoma and EBV-driven large B-cell lymphoma: A case report and review of literature

Synchronous colonic mucosa-associated lymphoid tissue lymphoma found after surgery for adenocarcinoma: A case report and review of literature

Synchronous or collision solid neoplasms and lymphomas: A systematic review of 308 case reports

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