Colonial organization and intercellular communication in microorganisms

Oleskin, Alexander V.; Botvinko, V.; Цавкелова, Е. А.

doi:10.1007/bf02756730

Cited by 42 publications

(20 citation statements)

References 57 publications

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“…Differentiation clearly occurs in cyanobacteria and, since metazoan PCD is regulated through cell signalling, the role of signalling in microalgal PCD needs greater attention, and will benefit from studies into the signalling molecules produced by microalgal cells in culture, and also in biofilms. Signalling within bacterial biofilms can lead to PCD via quorum-sensing (Oleskin et al, 2000), or through the induction of prophages and autotoxins (Webb et al, 2003). Quorum sensing (density-dependent gene expression) in bacteria also provides a plausible mechanism for ontogenetic differentiation.…”

Section: Pcd In Bacteria Yeast and Eukaryotic Protistsmentioning

confidence: 99%

What is the role and nature of programmed cell death in phytoplankton ecology?

Franklin

Berges

2006

European Journal of Phycology

169

155

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Section: Pcd In Bacteria Yeast and Eukaryotic Protistsmentioning

confidence: 99%

What is the role and nature of programmed cell death in phytoplankton ecology?

Franklin

Berges

2006

European Journal of Phycology

169

155

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“…Note that Eq. 5 says that the phase velocity depends only on the local cell density, i.e., we have not introduced any diffusible morphogen analogous to ''quorum sensing'' in bacteria with diffusible signals (15,16).…”

Section: [4]mentioning

confidence: 99%

Pattern formation and traveling waves in myxobacteria: Theory and modeling

Igoshin

Mogilner

Welch

et al. 2001

Proc. Natl. Acad. Sci. U.S.A.

138

176

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Recent experiments have provided new quantitative measurements of the rippling phenomenon in fields of developing myxobacteria cells. These measurements have enabled us to develop a mathematical model for the ripple phenomenon on the basis of the biochemistry of the C-signaling system, whereby individuals signal by direct cell contact. The model quantitatively reproduces all of the experimental observations and illustrates how intracellular dynamics, contact-mediated intercellular communication, and cell motility can coordinate to produce collective behavior. This pattern of waves is qualitatively different from that observed in other social organisms, especially Dictyostelium discoideum, which depend on diffusible morphogens. Myxobacteria are common components of soil, but their life cycle is far from common. Although they are prokaryotes, their life, in some respects, is similar to that of multicellular organisms (1, 2). Under starvation conditions, a population of myxobacterial cells aggregates by streaming into a number of central foci, eventually forming at the focus a multicellular fruiting body. During this aggregation phase, the cells may pass through a period where the surface is swept by a complex pattern of waves, called the ''ripple phase.'' These waves are composed of bacteria moving in concert in such a way that colliding waves appear to pass through one another (3). This is quite unlike the seemingly similar phenomenon observed in Dictyostelium discoideum and in chemical waves where colliding wave fronts annihilate one another (4, 5). Here we present a quantitative model for the ripple phase in Myxococcus xanthus that reproduces most of the observed phenomena. A distinguishing feature of this model is that it depends only on intercellular communication by direct cell contact, without any diffusible morphogen signaling.We shall base our model on the following consequences of experimental observations on Myxobacteria.(i) Contact Signaling. Myxobacteria signal via the C-signaling system, which operates only when two cells contact one another nearly end to end (3, 6, 7). The ripple patterns can be altered significantly, or even abolished, by manipulation of external C-signal protein concentration or dilution of wild-type cells by mutants that can receive, but not send, C-signal (3). Therefore, we shall base the model on signaling that depends entirely on direct cell contacts, with no diffusible signaling molecule.(ii) Reversal Cycle. Experiments on individual prerippling bacteria under various conditions show that they glide back and forth, reversing their direction spontaneously about every 5-10 min with a variance much smaller than the mean (see table 1 of ref. 8 and table 2 of ref. 9). Thus the times between reversals are not exponentially distributed, i.e., not Markovian. We interpret this to mean that the internal biochemical circuit controlling reversals contains a delay or cycle time for completion.(iii) Density Dependence. Measurements show that reversal frequencies depend on the amount of C...

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“…The bacterial colony in which the cells are tightly associated is the most common example of bacterial aggregates a microbiologist deals with. The colony is a complex structure composed of nonuniform cells [1]. In E. coli colonies, a vertical stratification is well developed with distinct cell layers differently susceptible to vital staining [36,37].…”

Section: Cell-cell Interactions Mediated By Physical Factors (Intercementioning

confidence: 99%

“…Now the novel idea that a bacterial population is a community of interacting cells with possible differentiation in this supracellular "organism" succeeds the old view on bacterial culture as a homogeneous soup in which individual cells live and proliferate independently of each other [1]. So, bacterial populations can be brought into comparison with tissues of higher organisms by their organization.…”

mentioning

confidence: 94%

Cell?cell interactions in bacterial populations

Voloshin

Kaprelyants

2004

Biochemistry (Moscow)

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In developing bacterial populations many essential processes, such as division, genetic transformation, sporulation, and synthesis of antibiotics and secondary metabolites, are regulated by intercellular communication mediated by secretion of signaling molecules, such as homoserine lactones and peptides. Another intercellular communication type, namely a physical contact between cells (cell aggregation), plays a key role in formation of biofilms or cellular consortia and in cell proliferation under unfavorable conditions. The mechanisms involved in these two types of bacterial communication are discussed in this review.

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Colonial organization and intercellular communication in microorganisms

Cited by 42 publications

References 57 publications

What is the role and nature of programmed cell death in phytoplankton ecology?

What is the role and nature of programmed cell death in phytoplankton ecology?

Pattern formation and traveling waves in myxobacteria: Theory and modeling

Cell?cell interactions in bacterial populations

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