Colon targeting of celecoxib nanomixed micelles using pulsatile drug delivery systems for the prevention of inflammatory bowel disease

El-Hady, Shaymaa M.; AbouGhaly, Mohamed H.H.; El-Ashmoony, Manal M; Helmy, Hanan; El‐Gazayerly, Omaima N.

doi:10.1016/j.ijpharm.2019.118982

Cited by 18 publications

(10 citation statements)

References 70 publications

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“…The PDDS tablet plugs based on time-controlled polymers holds a great promise for celecoxib delivery . Number of polymers including cellulose, HPMC, and chitosan are well suited for PDDS tablet plugs.…”

Section: Type Of Tabletized Nanomedicinementioning

confidence: 99%

“…Number of polymers including cellulose, HPMC, and chitosan are well suited for PDDS tablet plugs. This system can reduce inflammatory markers, myeloperoxidase (MPO, intestinal inflammatory marker), tumor necrosis factor-alpha (TNF-α, intestinal inflammation due to alternation in epithelial cell barrier), and interferon-gamma (IFN-γ, inducer of nitric oxide generation in epithelial cells to detect integrity of colonic mucosa) . In such systems, the choice and proportion of diverse hydrophilic polymers in PDDS govern the tablet’s characteristics.…”

Section: Type Of Tabletized Nanomedicinementioning

confidence: 99%

Section: Type Of Tabletized Nanomedicinementioning

confidence: 99%

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Tabletized Nanomedicine: From the Current Scenario to Developing Future Medicine

Tiwari,

Kolli,

Chauhan

et al. 2024

ACS Nano

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The limitations of conventional therapeutic treatments prevailed in the development of nanotechnology-based medical formulations, termed nanomedicine. Nanomedicine is an advanced medicine that often consists of therapeutic agent(s) embedded in biodegradable or biocompatible nanomaterial-based formulations. Among nanomedicine approaches, tablet (oral) nanomedicine is still under development. In tabletized nanomedicine, the dynamic interplay between nanoformulations and the intricate milieu of the gastrointestinal tract simulates a pivotal role, particularly accentuating the influence exerted upon the luminal, mucosal, and epithelial cells. In this work, we document the perspectives and opportunities of nanoformulations toward the development of tabletized nanomedicine. This review also unveils the notion of integrating nanomedicine within a tablet formulation, which facilitates the controlled release of drugs, biomolecules, and agent(s) from the formulation to achieve a better therapeutic response. Finally, an attempt was made to explore current trends in nanomedicine technology such as bacteriophage, probiotic, and oligonucleotide tabletized nanomedicine and the combination of nanomedicine with imaging agents, i.e., nanotheranostics.

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Section: Type Of Tabletized Nanomedicinementioning

confidence: 99%

Section: Type Of Tabletized Nanomedicinementioning

confidence: 99%

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Tabletized Nanomedicine: From the Current Scenario to Developing Future Medicine

Tiwari,

Kolli,

Chauhan

et al. 2024

ACS Nano

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show abstract

“…Therefore, specific and selective delivery to the colon is required to produce local effects and minimize side effects. The low solubility and dissolution rate of celecoxib in the gastrointestinal tract is a challenge in administering the drug through the oral route, hence, various strategies are needed (El-hady et al, 2020). studied CTDD with guar gum as a carrier to be degraded by colonic bacteria.…”

Section: Other Celecoxibmentioning

confidence: 99%

“…The study showed that a pulsatile capsule containing 75% Carbopol as a timedependent polymer yielded 88.35% of the dose released after a lag period of 8 hours. The system has a protective effect against experimentallyinduced colitis (El-hady et al, 2020).…”

Section: Other Celecoxibmentioning

confidence: 99%

Delivery of Potential Drugs to The Colon: Challenges and Strategies

Iswandana

Putri²,

Larasati³

et al. 2022

Indonesian J Pharm

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Colon-targeted drug delivery systems have been exploited to treat local diseases in the colon, systemic delivery of protein and peptide, and chronotherapeutic drugs. The upper gastrointestinal tract restricts the effective delivery of these drugs. Therefore, several strategies are needed for targeted drugs directly to the colon, such as pH-sensitive polymers, enzyme-sensitive polymers, bacterially degradable polysaccharides, time-dependent polymers, and particulate systems. However, variable physiological conditions of the gastrointestinal tract in individuals cause combinations of these strategies are needed to ensure colonic delivery of the drug. This review presents and discusses several potential drugs and their approaches used to design and develop colon-targeted drug delivery systems for medications with particular characteristics.

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4-Octyl itaconate alleviates dextran sulfate sodium-induced ulcerative colitis in mice via activating the KEAP1-NRF2 pathway

Wang,

Zhao,

Gao

et al. 2024

Inflammopharmacol

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Colon targeting of celecoxib nanomixed micelles using pulsatile drug delivery systems for the prevention of inflammatory bowel disease

Cited by 18 publications

References 70 publications

Tabletized Nanomedicine: From the Current Scenario to Developing Future Medicine

Tabletized Nanomedicine: From the Current Scenario to Developing Future Medicine

Delivery of Potential Drugs to The Colon: Challenges and Strategies

4-Octyl itaconate alleviates dextran sulfate sodium-induced ulcerative colitis in mice via activating the KEAP1-NRF2 pathway

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