Colon-Targeted Layer-by-Layer Self-assembled Film: Pharmacokinetic Analysis of BCS Class I and Class III Model Drugs

Janardhanam, Leela Sai Lokesh; Deokar, Ashwini Suresh; Bollareddy, Srivarsha Reddy; Venuganti, Venkata Vamsi Krishna

doi:10.1208/s12249-022-02450-2

Cited by 4 publications

(1 citation statement)

References 56 publications

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“…Alginate decoration lets NPs have stronger mucoadhesion with lower oral absorption, which resulted in better effects of SA-TMC-NPs on colitis than TMC-NPs. Janardhanam et al [34] prepared a layer-by-layer film with chitosan and sodium alginate polyelectrolytes contain-ing either 5-fluorouracil (5FU) or moxifloxacin HCl (MF). Comparing with intravenous injection, oral administration of these two NPs led to a higher accumulation of loaded drugs (5FU for 2.37 times and MF for 7.10 times) in the colon tissues.…”

Section: Chitosan and Its Derivativesmentioning

confidence: 99%

Self-Assembled Polymers for Gastrointestinal Tract Targeted Delivery through the Oral Route: An Update

Yang,

et al. 2023

Polymers

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Gastrointestinal tract (GIT) targeted drug delivery systems have gained growing attention as potential carriers for the treatment of different diseases, especially local colonic diseases. They have lower side effects as well as enhanced oral delivery efficiency because of various therapeutics that are vulnerable to acidic and enzymatic degradation in the upper GIT are protected. The novel and unique design of self-assembled nanostructures, such as micelles, hydrogels, and liposomes, which can both respond to external stimuli and be further modified, making them ideal for specific, targeted medical needs and localized drug delivery treatments through the oral route. Therefore, the aim of this review was to summarize and critically discuss the pharmaceutical significance and therapeutic feasibility of a wide range of natural and synthetic biomaterials for efficient drug targeting to GIT using the self-assembly method. Among various types of biomaterials, natural and synthetic polymer-based nanostructures have shown promising targeting potential due to their innate pH responsiveness, sustained and controlled release characteristics, and microbial degradation in the GIT that releases the encapsulated drug moieties.

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Section: Chitosan and Its Derivativesmentioning

confidence: 99%