Colon-targeted delivery of polyphenols: construction principles, targeting mechanisms and evaluation methods

Wang, Yidi; Li, Zhiying; Bao, Yiwen; Cui, Huijun; Li, Jiaxin; Song, Baoge; Wang, Mengzhu; Li, Haikun; Cui, Xingyue; Chen, Yi; Chen, Wei; Yang, Shufang; Yang, Yiyun; Jin, Zhufeng; Si, Xu; Li, Bin

doi:10.1080/10408398.2023.2266842

Cited by 2 publications

(2 citation statements)

References 159 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The human GIT contains a large number of anaerobic and aerobic bacteria. However, the upper part of the small intestine has a relatively low bacterial population (10 4 CFU/g) compared to the colon (10 11 CFU/g), where up to 1000 bacterial species are found, most of which are anaerobic (Wang et al, 2023). Upon reaching the colon, probiotics must compete with already present microorganisms, adhere to the intestinal mucus layer, and then colonize and proliferate.…”

Section: Colonmentioning

confidence: 99%

Oral delivery of probiotics using single‐cell encapsulation

Han,

McClements,

Liu

et al. 2024

Comp Rev Food Sci Food Safe

View full text Add to dashboard Cite

Adequate intake of live probiotics is beneficial to human health and wellbeing because they can help treat or prevent a variety of health conditions. However, the viability of probiotics is reduced by the harsh environments they experience during passage through the human gastrointestinal tract (GIT). Consequently, the oral delivery of viable probiotics is a significant challenge. Probiotic encapsulation provides a potential solution to this problem. However, the production methods used to create conventional encapsulation technologies often damage probiotics. Moreover, the delivery systems produced often do not have the required physicochemical attributes or robustness for food applications. Single‐cell encapsulation is based on forming a protective coating around a single probiotic cell. These coatings may be biofilms or biopolymer layers designed to protect the probiotic from the harsh gastrointestinal environment, enhance their colonization, and introduce additional beneficial functions. This article reviews the factors affecting the oral delivery of probiotics, analyses the shortcomings of existing encapsulation technologies, and highlights the potential advantages of single‐cell encapsulation. It also reviews the various approaches available for single‐cell encapsulation of probiotics, including their implementation and the characteristics of the delivery systems they produce. In addition, the mechanisms by which single‐cell encapsulation can improve the oral bioavailability and health benefits of probiotics are described. Moreover, the benefits, limitations, and safety issues of probiotic single‐cell encapsulation technology for applications in food and beverages are analyzed. Finally, future directions and potential challenges to the widespread adoption of single‐cell encapsulation of probiotics are highlighted.

show abstract

Section: Colonmentioning

confidence: 99%

Oral delivery of probiotics using single‐cell encapsulation

Han,

McClements,

Liu

et al. 2024

Comp Rev Food Sci Food Safe

View full text Add to dashboard Cite

show abstract

“…Polyphenols are nature-derived biologically active substances, which broadly participate in the modulation of oxidative stress and inflammatory pathways. − Owing to the distinctive structural characteristics, polyphenols have gained considerable attention in a wide range of biological activity. , However, their precise delivery to the diseased site is required to enhance the therapeutic efficacy and minimize the systemic exposure. In recent years, nanotechnology represents a breakthrough in precise drug delivery. , Fortunately, polyphenols as building blocks for particle assembly have achieved improved bioavailability and targeted delivery capability. ,, Due to its multiple hydroxyl groups and a phenolic structure, tannic acid (TA) is an excellent candidate for nanoparticle engineering.…”

Section: Introductionmentioning

confidence: 99%

Polyphenolic Nanoparticle-Modified Probiotics for Microenvironment Remodeling and Targeted Therapy of Inflammatory Bowel Disease

Hu,

Li,

Wang

et al. 2024

ACS Nano

View full text Add to dashboard Cite

Inflammatory bowel diseases (IBDs) refer to multifaceted disorders in the intestinal microenvironment and microbiota homeostasis. In view of the broad bioactivity and high compatibility of polyphenols, there is considerable interest in developing a polyphenol-based collaborative platform to remodel the IBD microenvironment and regulate microbiota. Here, we demonstrated the coordination assembly of nanostructured polyphenols to modify probiotics and simultaneously deliver drugs for IBD treatment. Inspired by the distinctive structure of tannic acid (TA), we fabricated nanostructured pBDT-TA by using a self-polymerizable aromatic dithiol (BDT) and TA, which exhibited excellent antioxidant and anti-inflammatory capability in vitro. We thus coated pBDT-TA and sodium alginate (SA) to the surface of Escherichia coli Nissle 1917 layer by layer to construct the collaborative platform EcN@SA-pBDT-TA. The modified probiotics showed improved resistance to oxidative and inflammatory stress, which resulted in superior colon accumulation and retention in IBD model mice. Further, EcN@SA-pBDT-TA could alleviate dextran sulfate sodium (DSS)-induced colitis by controlling the inflammatory response, repairing intestinal barriers, and modulating gut microbiota. Importantly, EcN@SA-pBDT-TA-mediated IBD drug delivery could achieve an improved therapeutic effect in DSS model mice. Given the availability and functionality of polyphenol and prebiotics, we expected that nanostructured polyphenol-modified probiotics provided a solution to develop a collaborative platform for IBD treatment.

show abstract

Colon-targeted delivery of polyphenols: construction principles, targeting mechanisms and evaluation methods

Cited by 2 publications

References 159 publications

Oral delivery of probiotics using single‐cell encapsulation

Oral delivery of probiotics using single‐cell encapsulation

Polyphenolic Nanoparticle-Modified Probiotics for Microenvironment Remodeling and Targeted Therapy of Inflammatory Bowel Disease

Contact Info

Product

Resources

About