Colon-targeted celecoxib-loaded Eudragit^®S100-coated poly-ϵ-caprolactone microparticles: Preparation, characterization andin vivoevaluation in rats

Abstract

The developed double-coat microparticles could be considered as a promising celecoxib extended-release colon-targeting system.

Positively Charged Polymeric Nanoparticle Reservoirs of Terbinafine Hydrochloride: Preclinical Implications for Controlled Drug Delivery in the Aqueous Humor of Rabbits

“…This might be attributed to the higher emulsification power associated with the use of a higher amount of the surfactant. The lower surfactant concentrations might not be able to cover the entire organic droplet surface (35). Thereby; some of the droplets would tend to aggregate till the surface area is decreased to a point that the available amount of surfactant was able to coat the entire surface of the agglomerate and thus forming a stable emulsion with relatively larger droplets.…”

Duodenum-triggered delivery of pravastatin sodium: II. Design, appraisal and pharmacokinetic assessments of enteric surface-decorated nanocubosomal dispersions

“…Regardless of the surfactant type, an inverse relationship was established between the surfactant concentration and the mean particle diameter. At a GMO: surfactant ratio of 5:1, the surfactant molecules might be unable to cover the entire particle surface allowing for the aggregation of some particles till their surface area is decreased to a point that the limited surfactant concentration could coat the entire agglomerate surface and consequently, form a stable dispersion with relatively larger particles (Ghorab et al, 2011). The higher surfactant concentration, with respect to a fixed concentration of GMO, would allow for the partitioning of more surfactant molecules into the interfacial domain of the liquid crystalline phase.…”

“…The differential scanning calorimetry (DSC) thermograms of the samples were recorded on a differential scanning calorimeter (DSC-60, Shimadzu, Kyoto, Japan) to describe their thermotropic properties and to estimate their degree of crystallinity and/or the possible incompatibilities between PVS and GMO. Briefly, three to four milligram samples were heated in hermetically sealed flat-bottom aluminum pans over a temperature range of C, at a rate of 10 C/min, under a nitrogen purge of 30 ml/min (Ghorab et al, 2011).…”

Getting into the colon: approaches to target colorectal cancer

“…Celecoxib [20] Tablets A release modulated colon targeted system of meloxicam for potential application in the prophylaxis of colorectal cancer was prepared. Dually coated tablets containing polyethylene oxide as release retardant were prepared by direct compression technique.…”