Colon‐Targeted Adhesive Hydrogel Microsphere for Regulation of Gut Immunity and Flora (Adv. Sci. 18/2021)

Lee, Hua; Cai, Zhengwei; Wang, Fei; Hong, Liwen; Deng, Lianfu; Zhong, Jie; Wang, Zhengting; Cui, Wenguo

doi:10.1002/advs.202170115

Cited by 42 publications

(30 citation statements)

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“…The morphology of the microspheres was visualized by an inverted microscope (Nikon, Japan) and the diameter of the microspheres was analyzed by the Image J software (NIH, USA). [ 24 ] Microcompression test was performed using TA. XTPlus texture analyzer (Stable Micro Systems, UK) to determine the Young's modulus of the micropheres as previously described.…”

Section: Methodsmentioning

confidence: 99%

Electrosprayed Regeneration‐Enhancer‐Element Microspheres Power Osteogenesis and Angiogenesis Coupling

Yang

Suo

et al. 2022

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Electrosprayed microspheres for bone regeneration are conventionally restricted by the lack of osteogenic modulation for both encapsulated stem cells and surrounding cells at the defect site. Here, sodium alginate microspheres encapsulating L‐arginine doped hydroxyapatite nanoparticles (Arg/HA NPs) and bone mesenchymal stem cells (BMSCs) as regeneration‐enhancer‐element reservoirs (Arg/HA‐SA@BMSC) for bone healing are electrosprayed. The Arg/HA NPs serve as a container of L‐arginine and Ca2+ and the BMSCs inside the microspheres metabolize the released L‐arginine into bioactive gas nitric oxide (NO) in the presence of Ca2+ to activate the nitric oxide (NO)/cyclic guanosine monophosphate (cGMP) signaling pathway. Meanwhile, the generated NO diffuses out of the microspheres together with the Ca2+ and L‐arginine as exterior enhancers to promote the osteogenesis–angiogenesis coupling of surrounding BMSCs and endothelial cells (ECs) at the bone defect site, generating an internal/external modulation loop between the encapsulated cells and surrounding native cells. It is demonstrated that such regeneration‐enhancer‐element reservoirs could effectively increase the bone tissue formation and neovasculature using rat calvarial defect models. It is envisioned that the microsphere system could streamline vascularized bone regeneration therapy as a high throughput, minimally invasive yet highly effective strategy to accelerate bone healing.

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Section: Methodsmentioning

confidence: 99%

Electrosprayed Regeneration‐Enhancer‐Element Microspheres Power Osteogenesis and Angiogenesis Coupling

Yang

Suo

et al. 2022

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“…In addition to the above main directions, MHS are favored in the treatment of cancer and other diseases because of its good biocompatibility, excellent drug loading and delivery capacity. Liu et al [154] . successfully prepared colon targeted adhesive core‐shell hydrogel microspheres via a combination of advanced gas shear technology and ion diffusion technology.…”

Section: Application Of Mhs Scaffolds For Tissue Engineeringmentioning

confidence: 99%

Microsphere‐containing Hydrogel Scaffolds for Tissue Engineering

Zhang

Lin

Tao

et al. 2022

Chemistry An Asian Journal

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Key Laboratory for Ultrafine Materials of Ministry of Education Centre for Biomedical Technologies Current tissue engineering technology aims to achieve the regeneration of human tissues, which integrates the key factors such as scaffolds, cells and biomolecules. Among these key factors, the development of high‐performance scaffolds is the basis for the success of tissue engineering strategies. In the past decades, hydrogel scaffolds have been developed rapidly and widely used in biomedical field, however, their drawbacks have also been revealed, which shows that a single hydrogel scaffold cannot meet the excellent performance required in the field of tissue engineering. Recently, microspheres have been further engineered to fabricate structurally and functionally reliable artificial three‐dimensional scaffolds of desired shape with enhanced specific biological functions. Therefore, the effective combination of hydrogel and microspheres can facilitate the development of high‐performance scaffolds for tissue engineering and further fine‐tuning the composite structure, which is expected to solve the dilemma faced by a single scaffold. In this review paper, we systematically summurized the type and preparation method for synthesis of hydrogel and microsphere materials commonly used in developing microsphere‐containing hydrogel scaffolds. We then reviewed the broad application of these hybrid scaffolds in various fields of tissue engineering, followed by a summary and perspective on future directions.

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“…However, the oral core–shell microspheres constructed with sodium alginate and calcium ions as package materials exhibit colon-targeting properties. In addition, the residence times of local microorganisms are prolonged for the collapse release mechanism, and the numbers of microorganisms increases the bioavailability [ 119 ]. Kamguyan et al developed a chitosan-coated microcontainer using L. rhamnosus as a model strain [ 120 ].…”

Section: A Microencapsulated Delivery System Can Protect Microorganis...mentioning

confidence: 99%

Microorganisms—An Effective Tool to Intensify the Utilization of Sulforaphane

Wang²,

Zhao³

et al. 2022

Foods

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Sulforaphane (SFN) was generated by the hydrolysis of glucoraphanin under the action of myrosinase. However, due to the instability of SFN, the bioavailability of SFN was limited. Meanwhile, the gut flora obtained the ability to synthesize myrosinase and glucoraphanin, which could be converted into SFN in the intestine. However, the ability of microorganisms to synthesize myrosinase in the gut was limited. Therefore, microorganisms with myrosinase synthesis ability need to be supplemented. With the development of research, microorganisms with high levels of myrosinase synthesis could be obtained by artificial selection and gene modification. Researchers found the SFN production rate of the transformed microorganisms could be significantly improved. However, despite applying transformation technology and regulating nutrients to microorganisms, it still could not provide the best efficiency during generating SFN and could not accomplish colonization in the intestine. Due to the great effect of microencapsulation on improving the colonization ability of microorganisms, microencapsulation is currently an important way to deliver microorganisms into the gut. This article mainly analyzed the possibility of obtaining SFN-producing microorganisms through gene modification and delivering them to the gut via microencapsulation to improve the utilization rate of SFN. It could provide a theoretical basis for expanding the application scope of SFN.

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Colon‐Targeted Adhesive Hydrogel Microsphere for Regulation of Gut Immunity and Flora (Adv. Sci. 18/2021)

Cited by 42 publications

References 0 publications

Electrosprayed Regeneration‐Enhancer‐Element Microspheres Power Osteogenesis and Angiogenesis Coupling

Electrosprayed Regeneration‐Enhancer‐Element Microspheres Power Osteogenesis and Angiogenesis Coupling

Microsphere‐containing Hydrogel Scaffolds for Tissue Engineering

Microorganisms—An Effective Tool to Intensify the Utilization of Sulforaphane

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