Colon polyposis excluding colon adenomatosis. Especially Cronkhite-Canada syndrome.

Goto, Ayana; Tarao, Makoto; Kano, Nobuyasu; Mimoto, Hiromichi; Matsunami, Eiichi

doi:10.3862/jcoloproctology.40.708

Cited by 3 publications

(3 citation statements)

References 3 publications

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“…According to the review by Goto et al [6][7][8] 270 cases had been reported worldwide until 1992. Among these cases, 204 cases (76% of all patients) had been reporred in Japan.…”

Section: Discussionmentioning

confidence: 99%

Adenomatous changes and K-ras codon 12 mutations in colonic polyps of Cronkhite-Canada syndrome

1997

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Summary. A 68-year-old man was admitted to our hospital with complaints of persisting diarrhea and change in taste sensation. Radiologic and endoscopic examination revealed multiple polypoid lesions in the stomach and colon. Histologic examination of colonic polyps revealed dilated glands in variable sizes containing mucin-producing goblet cells covered by a single layer of columnar epithelial cells anda diagnosis of Cronkhite-Canada (CC) syndrome was made. Also, during a clinical course of CC syndrome, the patient developed idiopathic multicentric osteolysis with acro-osteolysis. CC polyps are generally considered to be inflammatory or nonneoplastic. However, in our patient, 2 CC polyps showed adenomatous changes. By purifying the DNA from adenomatous component of these polyps, we examined the K-ras codon 12 mutation. Both lesions with adenoma showed the K-ras codon 12 mutation, while 1 CC polyp without adenoma did not show any mutation. Although malignant transformation of CC polyps has been considered to be extremely rare, our results indicated the possibility that CC polyps may undergo adenomatous of malignant transformation by alteration of various genes related to colorectal carcinogenesis. Therefore, careful attention should be paid for treating colonic polyps in CC patients.

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“…According to the review by Goto et al [6][7][8] 270 cases had been reported worldwide until 1992. Among these cases, 204 cases (76% of all patients) had been reporred in Japan.…”

Section: Discussionmentioning

confidence: 99%

Adenomatous changes and K-ras codon 12 mutations in colonic polyps of Cronkhite-Canada syndrome

1997

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“…Aufgrund dieser hohen Assoziation muß eine genetische Disposition zumindest diskutiert werden, obwohl eine spezifische Mutation eines bestimmten Genorts bisher nicht gefunden werden konnte [2,9,13,18,19,26,29,30,34]. Ü berwiegend handelte es sich um colorectale Carcinome, ohne daß im Einzelfall angegeben wurde, ob innerhalb oder außerhalb eines Polypen.…”

Section: Definitionunclassified

“…Außerdem fallen erweiterte Gefäße und oberflä chliche Erosionen auf. Darü ber hinaus wird berichtet, daß die Gabe von Corticosteroiden [2,9,11,21,25,42] und Antibiotica gü nstigen Einfluß besitzt. Erste Autoren interpretierten die polypö sen Verä nderungen als Adenome, zumal gelegentlich adematö se Verä nderungen innerhalb der Polypen vorkommen kö nnen [4,10,17].…”

Section: Lokalisation Und Morphologie Der Poylpen (Tabelle 1)unclassified

Das Cronkhite-Canada-Syndrom Epidemiologie, Symptomatik, Morphologie und Therapie anhand eines Fallberichts und der Literatur

Zügel

Tannapfel

Lembcke

et al. 1997

Chirurg

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Juvenile polyposis was first described by Cronkhite and Canada in 1955. This disease is characterized by juvenile intestinal polyps and ectodermal abnormalities. The etiology of Cronkhite-Canada syndrome (CCS), however, is still not well understood. Interestingly among patients with CCS a significant correlation (16.5%) with intestinal carcinomas has been observed. Thus, malignant transformation and/or genetic predisposition may be involved in the initiation of the disease. In the following, epidemiology, symptoms, morphology and therapy of CCS are discussed. Our examinations are based on studies reported in the literature and on a case report of a female patient who developed a colon carcinoma 2 years after initial diagnosis of CCS.

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Cronkhite Canada syndrome: case report with some features not previously described

Nardone¹,

D'Armiento²,

Carlomagno³

et al. 1990

Gastrointestinal Endoscopy

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Colon polyposis excluding colon adenomatosis. Especially Cronkhite-Canada syndrome.

Cited by 3 publications

References 3 publications

Adenomatous changes and K-ras codon 12 mutations in colonic polyps of Cronkhite-Canada syndrome

Adenomatous changes and K-ras codon 12 mutations in colonic polyps of Cronkhite-Canada syndrome

Das Cronkhite-Canada-Syndrom Epidemiologie, Symptomatik, Morphologie und Therapie anhand eines Fallberichts und der Literatur

Cronkhite Canada syndrome: case report with some features not previously described

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