Colon perforation with acute peritonitis after taking clindamycin and diclofenac following wisdom tooth removal

Colonic perforation after short-term use of nonsteroidal antiinflammatory drugs: report of two cases

“…However, adverse effects of NSAIDs on the small and large intestine are less well recognized and published material about them is limited. To our knowledge only one similar case has previously been reported [5]. The majority of the studies of lower GI side effects included patients using long-term slowrelease NSAIDs [5].…”

“…To our knowledge only one similar case has previously been reported [5]. The majority of the studies of lower GI side effects included patients using long-term slowrelease NSAIDs [5]. The effects of NSAIDs on the GI tract are both local and systemic [1,5].…”

“…Side effects of NSAIDs on the gastroduodenal mucosa are well recognized and many studies of these side effects have been published [2,5,7]. Thus, preventive measures are applied and if such side effects occur they are easily diagnosed.…”

“…The majority of the studies of lower GI side effects included patients using long-term slowrelease NSAIDs [5]. The effects of NSAIDs on the GI tract are both local and systemic [1,5]. Local injury to the intestinal mucosa is mainly due to the entry of the NSAIDs, especially slow-release NSAIDs, and their metabolites into the enterohepatic circulation [11].…”

“…Although the upper GI tract disturbances caused by NSAIDs are well known, their side effects in the lower GI tract are not clearly defined. There are a limited number of articles and case reports about the latter in the literature [5].…”